BIOSYNTHESIS AND ACTION OF EICOSANOIDS IN THE INFLAMMATORY PROCESS
DOI:
https://doi.org/10.66104/npraft23Keywords:
Prostaglandins; Metabolism; Lipids; Inflammation; Health.Abstract
Eicosanoids are hormones derived from polyunsaturated fatty acids, and are responsible for regulating the immune response, especially in the inflammatory process and in autoimmune diseases. Such substances may have a highly inflammatory nature, and are triggered by their level of concentration in the body, which leads to the development of cardiovascular diseases, cancer, neuroinflammation and anaphylaxis. Enzymes that are part of the metabolic process are the main targets of anti-inflammatory drugs. The present research aimed to investigate the metabolism of the main eicosanoids that act on the inflammatory response and characterize the polyunsaturated fatty acids that constitute the profile of these hormones. This study addresses the current understanding of the metabolism of eicosanoids and may contribute to the discovery of new biopharmaceuticals and consolidation of the knowledge on the pathophysiological process of inflammatory diseases.
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