COMPLICACIONES INTRAOPERATORIAS CAUSADAS POR ANESTESICOS QUE INDUCEN HIPERTERMIA MALIGNA PEDIÁTRICA
DOI:
https://doi.org/10.61164/rmnm.v12i4.3373Palabras clave:
Temperatura alta, Taquipnea, Hipercapnia, NiñosResumen
El objetivo de este estudio fue analizar la frecuencia de complicaciones intraoperatorias por anestésicos causantes de hipertermia maligna en pacientes pediátricos, evaluando además el procedimiento quirúrgico relacionado con el episodio y el desenlace clínico (supervivencia o muerte). Se realizó una revisión sistemática integradora, siendo los criterios de inclusión: publicaciones publicadas en los últimos 20 años y que trabajaran con pacientes pediátricos. Además, se excluyeron producciones repetidas y no aplicables a la temática propuesta. Se recolectaron previamente un total de 1.913 artículos y, luego de aplicar los factores de elegibilidad, 25 artículos constituyeron la muestra. Considerando los 42 casos clínicos de hipertermia maligna registrados entre los artículos seleccionados, se observó que entre las operaciones relacionadas con estos episodios de hipertermia maligna, el 21,4% (n = 9) de ellas fueron cirugías ortopédicas y entre las complicaciones intraoperatorias se destacaron: temperatura perioperatoria > 38,8ºC (n = 25, 59,5%), taquicardia sinusal inesperada (n = 24, 57,1%), PETCO2 > 55 mmHg, ventilación mecánica (n = 18, 42,9%) y pH < 7,25 (n = 16, 38,1%). Además, entre los pacientes que sucumbieron a estos episodios, 39 (92,9%) sobrevivieron. Se encontró que la mayoría de los pacientes pediátricos con hipertermia maligna sobreviven, aunque potencialmente puedan presentar morbilidades asociadas. Se evidenció que las cirugías más involucradas en los casos de hipertermia maligna pediátrica son las ortopédicas y que las complicaciones clínicas intraoperatorias más prevalentes en estos casos son el aumento significativo de la temperatura intraoperatoria y del PETCO2, además de la disminución sustancial del pH.
Referencias
ABOLKHAIR, A.; SEEFELDER, C. Malignant hyperthermia resolving with discontinuation of sevoflurane alone. Saudi Journal of Anaesthesia, v. 5, n. 2, p. 229-232, 2011. DOI: https://doi.org/10.4103/1658-354X.82816
ALI, L. et al. Survival of a malignant hyperthermia patient. Pakistan Armed Forces Medical Journal, v. 65, n. 1, p. 160-161, 2015.
ALMEIDA, C. G. de; COLLETI JUNIOR, J. Hipertermia maligna em criança após exame de ressonância magnética: relato de caso. Revista Paulista de Pediatria, v. 38, n. 1, p. e2018267, 2020.
ALTUĞ Ü. et al. A Case of Fatal Malignant Hyperthermia During Pes Equinovarus Surgery in a Child. Journal of Pediatric Emergency and Intensive Care Medicine, v. 5, n. 1, 2018. DOI: https://doi.org/10.4274/cayd.85570
AN, X. et al. Nursing interventions of intraoperative malignant hyperthermia in patients with scoliosis: a report of 3 cases. Journal of Neuroscience Nursing, v. 52, n. 2, p. 66-71, 2020. DOI: https://doi.org/10.1097/JNN.0000000000000496
ANDRADE, P. V. de et al. Fatigue, depression, and physical activity in patients with malignant hyperthermia: a cross-sectional observational study. Brazilian Journal of Anesthesiology, v. 73, n. 2, p. 132-137, 2023. DOI: https://doi.org/10.1016/j.bjane.2021.07.038
BAMAGA, A. K. et al. Neuromuscular conditions associated with malignant hyperthermia in paediatric patients: A 25-year retrospective study. Neuromuscular Disorders, v. 26, n. 3, p. 201-206, 2016. DOI: https://doi.org/10.1016/j.nmd.2016.02.007
BARBIER, M. et al. A case of malignant hyperthermia arising five hours after the beginning of anaesthesia with sevoflurane and after five uneventful surgical procedures. Annales Francaises D'anesthesie et de Reanimation. v. 28, n. 1, p. 983-987, 2009.
BONCIU, M. et al. Minor increase of endtidal CO2 during sevoflurane‐induced malignant hyperthermia. Pediatric Anesthesia, v. 17, n. 2, p. 180-182, 2007. DOI: https://doi.org/10.1111/j.1460-9592.2006.02051.x
BROMAN, M.; ISLANDER, G.; MÜLLER, C. R. Malignant hyperthermia, a Scandinavian update. Acta Anaesthesiologica Scandinavica, v. 59, n. 8, p. 951-961, 2015. DOI: https://doi.org/10.1111/aas.12541
CIENIEWICZ A. et al. Malignant hyperthermia - What do we know in 2019? Anaesthesiology Intensive Therapy. v. 51, n. 3, 169–177, 2019. DOI: https://doi.org/10.5114/ait.2019.87646
COSTA W. P. da et al. Malignant hyperthermia: reviewing important aspects. Revista Médica de Minas Gerais, v. 27, n. 2, p. 67-73, 2017. DOI: https://doi.org/10.5935/2238-3182.20170018
DE SOUSA, M. N. A.; BEZERRA, A. L. D.; DO EGYPTO, I. A. S. Trilhando o caminho do conhecimento: o método de revisão integrativa para análise e síntese da literatura científica. Observatório de la Economía Latinoamericana, v. 21, n. 10, p. 18448-18483, 2023. DOI: https://doi.org/10.55905/oelv21n10-212
EDWARDS, C. et al. A Single-Center Retrospective Review of Patients with Suspected Malignant Hyperthermia Susceptibility. Cureus, v. 15 n. 9, 2023. DOI: https://doi.org/10.7759/cureus.44661
EVANS, T. A. et al. Malignant hyperthermia in a 3-year-old child with microstomia. Journal of Craniofacial Surgery, v. 26, n. 1, p. 217-219, 2015. DOI: https://doi.org/10.1097/SCS.0000000000001258
FANG, S. et al. Continuous veno-venous hemofiltration for massive rhabdomyolysis after malignant hyperthermia: report of 2 cases. Anesthesia Progress, v. 60, n. 1, p. 21-24, 2013. DOI: https://doi.org/10.2344/11-000240.1
FERHI, F. et al. Malignant hyperthermia in a 4-year-old girl during anesthesia induction with sevoflurane and succinylcholine for congenital ptosis surgery. Saudi Journal of Ophthalmology, v. 33, n. 2, p. 183-187, 2019. DOI: https://doi.org/10.1016/j.sjopt.2018.10.002
FERNANDES, C. R. et al. Recrudescencia fatal de hipertermia maligna en lactante con el síndrome de Moebius. Relato de caso. Revista Brasileira de Anestesiologia, v. 63, p. 296-300, 2013. DOI: https://doi.org/10.1016/j.bjanes.2012.06.008
FUKAMI, M. C.; GANZBERG, S. I. A case report of malignant hyperthermia in a dental clinic operating room. Anesthesia Progress, v. 52, n. 1, p. 24-28, 2005. DOI: https://doi.org/10.2344/0003-3006(2005)52[24:ACROMH]2.0.CO;2
GARCÍA-MURO, C. et al. Síndrome de hipertermia maligna: una patología infrecuente. Boletín Médico del Hospital Infantil de Mexico, v. 77, n. 6, p. 337-340, 2020. DOI: https://doi.org/10.24875/BMHIM.20000047
GONG, X. Malignant hyperthermia when dantrolene is not readily available. BMC Anesthesiology, v. 21, n. 1, p. 1-11, 2021. DOI: https://doi.org/10.1186/s12871-021-01328-3
GOPALAKRISHNAN, C. V.; SUPARNA, B.; ARUN, V. A rare case of malignant hyperthermia in the Indian subcontinent. Anaesthesia, v. 65, n. 11, p. 1141-1142, 2010. DOI: https://doi.org/10.1111/j.1365-2044.2010.06515.x
HOPKINS, P. M. et al. Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists. Anaesthesia, v. 76, n. 5, p. 655-664, 2021. DOI: https://doi.org/10.1111/anae.15317
HOPKINS, P. M. et al. Tratamento de emergência na hipertermia maligna. SAMG - Sociedade de Anestesiologia do Estado de Minas Gerais, v. 1, n. 1, 2023.
JIANG, W. et al. Different ethanol exposure durations affect cytochrome P450 2E1-mediated sevoflurane metabolism in rat liver. BMC Anesthesiology, v. 24, n. 1. 2024. DOI: https://doi.org/10.1186/s12871-024-02704-5
KIM, H. Y.; KIM, Y. J. Malignant hyperthermia during general anesthesia for a surgery of idiopathic scoliosis: A case report. Korean Journal of Anesthesiology, v. 57, n. 5, p. 656-661, 2009. DOI: https://doi.org/10.4097/kjae.2009.57.5.656
KLINGLER W. et al. Functional and genetic characterization of clinical malignant hyperthermia crises: a multi-centre study. Orphanet Journal Rare Diseases, v. 1, n. 1, 2014. DOI: https://doi.org/10.1186/1750-1172-9-8
LAHA, S. et al. Life-threatening episodes of malignant hyperthermia following halothane anesthesia in three children: a case series and review of literature. Indian Journal of Critical Care Medicine, v. 23, n. 1, p. 47, 2019. DOI: https://doi.org/10.5005/jp-journals-10071-23112
LAN, H. et al. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2° C. Open Medicine, v. 18, n. 1, p. 20230808, 2023. DOI: https://doi.org/10.1515/med-2023-0808
LARACH M. G. et al. A clinical grading scale to predict malignant hyperthermia susceptibility. Anesthesiology, v. 80, n. 4, p. 771-779, 1994. DOI: https://doi.org/10.1097/00000542-199404000-00008
LARACH, M. G. et al. Cardiac arrests and deaths associated with malignant hyperthermia in North America from 1987 to 2006: a report from the North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States. The Journal of the American Society of Anesthesiologists, v. 108, n. 4, p. 603-611, 2008. DOI: https://doi.org/10.1097/ALN.0b013e318167aee2
LAVEZZI, W. A. et al. Death in the emergency department: an unrecognized awake malignant hyperthermia-like reaction in a six-year-old. Anesthesia & Analgesia, v. 116, n. 2, p. 420-423, 2013. DOI: https://doi.org/10.1213/ANE.0b013e3182768f99
LIMA, R. A.; BARAUNA, K. C.; NUNES, R. B. S. Hipertermia maligna: uma revisão da literatura. Brazilian Journal Health Review, v. 3, n. 2, p. 2475-2489, 2020. DOI: https://doi.org/10.34119/bjhrv3n2-096
LITMAN, R. S. et al. Malignant hyperthermia susceptibility and related diseases. Anesthesiology, v. 128, n. 1, p. 159-167, 2018. DOI: https://doi.org/10.1097/ALN.0000000000001877
LIU, S.; LIU, L.; WANG, S. Treatment of malignant hyperthermia without dantrolene in a 14-year-old boy. Chinese Medical Journal, v. 130, n. 6, p. 755-756, 2017. DOI: https://doi.org/10.4103/0366-6999.201616
MACIEL, S. F. V. de O. et al. Novas Variantes Patogênicas Em Paciente Com Miopatia Do Cerne Central E Susceptibilidade À Hipertermia Maligna. Revista Brasileira de Neurologia e Psiquiatria, v. 25, n. 1, 2021.
MAILE, M. D. et al. Um caso de hipertermia maligna capturado por um sistema de gerenciamento de informações de anestesia. Journal of Clinical Monitoring and Computing, v. 25, n. 1, p. 109-111, 2011.
MATHUR, P. R. et al. Malignant hyperthermia in a 6-month-old infant. Saudi Journal of Anaesthesia, v. 10, n. 3, p. 353-355, 2016. DOI: https://doi.org/10.4103/1658-354X.174915
MELO, M. et al. Interações medicamentosas no bloqueio neuromuscular despolarizante na anestesia geral. Revista Terra & Cultura: Cadernos De Ensino E Pesquisa, v. 32, n. 62, p. 33-42, 2018.
MINAMI, S. et al. Pediatric fulminant malignant hyperthermia with severe electroencephalographic abnormality and brain damage: a case report. Journal of Medical Case Reports, v. 17, n. 1, p. 140, 2023. DOI: https://doi.org/10.1186/s13256-023-03887-0
MIRANDA, T. S. et al. Manejo e identificação de pacientes susceptíveis à hipertermia maligna: uma revisão bibliográfica. Revista Eletrônica Acervo Científico, v. 20, n. 1, p. e4751-e4751, 2021. DOI: https://doi.org/10.25248/reac.e4751.2021
NESHATI, M. et al. Malignant hyperthermia: report of two cases with a neglected complication in cardiac surgery. The Journal of Tehran University Heart Center, v. 12, n. 4, p. 175, 2017.
NIMMO, A. F. et al. Guidelines for the safe practice of total intravenous anaesthesia (TIVA) joint guidelines from the association of anaesthetists and the society for intravenous anaesthesia. Anaesthesia, v. 74, n. 2, p. 211-224, 2019. DOI: https://doi.org/10.1111/anae.14428
NNAMANI, N. P.; MOSS, D. R. Babies in distress: Malignant hyperthermia in infancy explored. Clinical Pediatrics, v. 54, n. 6, p. 557-562, 2014. DOI: https://doi.org/10.1177/0009922814556981
OJEDA, G. et al. Hipertermia maligna. Aspectos históricos. Revista Chilena de Anestesia, v. 46, n. 1, p. 19-24, 2017. DOI: https://doi.org/10.25237/revchilanestv46n01.04
OKOLI, C. Guia para realizar uma Revisão Sistemática de Literatura. EAD em Foco, v. 9, n. 1, 2019. DOI: https://doi.org/10.18264/eadf.v9i1.748
ORTIZ-BAUTISTA, J. G.; COLIN-HERNANDEZ, J.; LEON-ALVAREZ, E. Hipertermia maligna. Revista Mexicana de Anestesiología, v. 46, n. 1, p. 38-45, 2023. DOI: https://doi.org/10.35366/108621
PAGE, M. J. et al. A declaração PRISMA 2020: diretriz atualizada para relatar revisões sistemáticas. Revista Panamericana de Salud Publica, v. 46, n. 1, p. e112, 2022. DOI: https://doi.org/10.26633/RPSP.2022.112
PANDIT, J. J. et al. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors. British Journal of Anaesthesia, v. 113, n. 4, p. 549-559, 2014. DOI: https://doi.org/10.1093/bja/aeu313
PLURAD, D. et al. A case of malignant hyperthermia in a child encountered during a humanitarian assistance mission to the Philippines. Military Medicine, v. 173, n. 8, p. 805-808, 2008. DOI: https://doi.org/10.7205/MILMED.173.8.805
RIAZI, S. et al. Malignant hyperthermia in Canada: characteristics of index anesthetics in 129 malignant hyperthermia susceptible probands. Anesthesia & Analgesia, v. 118, n. 2, p. 381-387, 2014. DOI: https://doi.org/10.1213/ANE.0b013e3182937d8b
RODRIGUES, G.; SILVA, H. C. A. da. Elaboração de Manual de Orientações sobre Hipertermia Maligna para Pacientes. Revista Neurociências, v. 29, n. 1, p. 1-59, 2021. DOI: https://doi.org/10.34024/rnc.2021.v29.12345
RODRIGUES, G. et al. Patient suspected susceptibility to malignant hyperthermia: impact of the disease. Brazilian Journal of Anesthesiology, v. 73, n. 2, p. 138-144, 2023. DOI: https://doi.org/10.1016/j.bjane.2021.10.021
ROSENBAUM, H. K.; ROSENBERG, H. Malignant hyperthermia: Diagnosis and management of acute crisis. Edited by Jones SB, v. 25, n. 1, 2022. DOI: https://doi.org/10.1007/978-3-319-20790-2_64-1
ROSENBERG H. et al. Hyperthermia Susceptibility. GeneReviews, v. 1, n. 1, 2020.
ROSENBERG H. et al. Malignant hyperthermia. Orphanet Journal of Rare Diseases, v. 2, n. 21, 2007. DOI: https://doi.org/10.1186/1750-1172-2-21
ROSENBERG H. et al. Malignant hyperthermia: a review. Orphanet Journal of Rare Diseases, v. 10, n. 1, p. 1-19, 2015. DOI: https://doi.org/10.1186/s13023-015-0310-1
SCHUSTER, F. et al. Evaluation of suspected malignant hyperthermia events during anesthesia. BMC Anesthesiology, v. 13, p. 1-7, 2013. DOI: https://doi.org/10.1186/1471-2253-13-24
SILVA, H. C. A. da et al. Hipertermia maligna en Brasil: análisis de la actividad del hotline en 2009. Revista Brasileira de Anestesiologia, v. 63, n. 1, p. 20-26, 2013. DOI: https://doi.org/10.1016/j.bjanes.2012.03.001
SOUSA, C. S. et al. Educational intervention on malignant hyperthermia with nursing professionals of the operating room. Revista da Escola de Enfermagem da USP, v. 49, n. 2, p. 292-297, 2015. DOI: https://doi.org/10.1590/S0080-623420150000200015
SPAGNOL, D. et al. Hipertermia maligna: uma revisão bibliográfica. Brazilian Journal of Health Review, v. 7, n. 5, p. e72639, 2024. DOI: https://doi.org/10.34119/bjhrv7n5-099
SRINIVASAN, S. P.; ELDO, N.; NAIR, S. G. Malignant hyperthermia during pediatric kidney transplantation—A medical and ethical quandary. Pediatric Transplantation, v. 25, n. 3, p. e13923, 2020. DOI: https://doi.org/10.1111/petr.13923
SUMITANI M. et al. Prevalence of malignant hyperthermia and relationship with anesthetics in Japan: data from the diagnosis procedure combination database. The Journal of the American Society of Anesthesiologists, v. 114, n. 1, p. 84-90, 2011.
TAN, L. et al. Clinical features of suspected malignant hyperthermia in China from 2015 to 2020: a retrospective study from China malignant hyperthermia emergency assistance group. Journal of Multidisciplinary Healthcare, v. 15, n. 1, p. 3005-3013, 2022. DOI: https://doi.org/10.2147/JMDH.S387208
TSUTSUMI, Y. M. et al. Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report. Journal of Anesthesia, v. 35, p. 311-314, 2021. DOI: https://doi.org/10.1007/s00540-021-02902-2
YANG L. et al. The current status of malignant hyperthermia. Journal of Biomedical Research, v. 34, n. 2, p. 75–85, 2020. DOI: https://doi.org/10.7555/JBR.33.20180089
ZHANG, D.; HU, Y.; YANG, Z. Effects of Isoflurane and Sevoflurane Inhalation Anesthesia on Microcirculatory Leukocyte Activity in Skeletal Muscle of Rats. Acta Microscopica, v. 29, n. 5, 2020.
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2024 Revista Multidisciplinar do Nordeste Mineiro
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
