RUG-NUTRIENT INTERACTION: ARE NUTRITIONISTS PREPARED?
DOI:
https://doi.org/10.66104/w3nw8116Keywords:
food-drug interactions; food; absorption; nutritional status; drug therapy, nutritionists.Abstract
Introduction: Drug-nutrient interaction refers to the way in which nutrients from food interact with medications, and how they interfere with the therapeutic response through possible alterations they cause in the body. Objective: To highlight and discuss the nutritional aspects of drug-nutrient interactions and whether nutritionists are prepared to manage these situations. Methodology: Narrative review study with information search in the electronic databases PubMed/Medline, Lilacs and Scielo, using the terms and descriptors "food-drug interaction", "food", "absorption", "nutritional status", "drug treatment" and "nutritionists", whose studies were published between 2000 and 2025. Results: From the discussion points, it was possible to understand that drug-nutrient interactions are characterized by alterations in the pharmacokinetic and pharmacodynamic mechanisms of a drug or nutrient, and that drugs can modify the metabolism of nutrients, and these interactions usually impact nutritional status. However, the few studies on the subject show that nutrition academics and nutritionists have knowledge gaps and uncertainties regarding drug-nutrient interactions. Final considerations: the knowledge gap and uncertainties on the part of nutritionists in managing drug-nutrient interactions may be related to a potentially systemic failure involving training, service, multidisciplinary team, and institutional policies.
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ANTUNES, Aline; LO PRETE, Ana Cristina. O Papel da atenção farmacêutica frente às interações fármaco-nutriente. Infarma - Ciências Farmacêuticas, [S. l.], v. 26, n. 4, p. 208–214, dez. 2014. DOI: 10.14450/2318-9312.v26.e4.a2014.pp 208-214. DOI: https://doi.org/10.14450/2318-9312.v26.e4.a2014.pp208-214
BEIRÃO, Sofia; COSTA G, João; FERREIRA PÊGO, Cíntia. Assessing knowledge and awareness of Food and Drug Interactions among nutrition sciences students: Implications for education and clinical practice. Nutr Health. 2025 Sep; 31(3):995-1002. doi: 10.1177/02601060241263409. Epub 2024 Jul 23. PMID: 39042902; PMCID: PMC12423472. DOI: https://doi.org/10.1177/02601060241263409
BERTRAND, Brenda et al. ACE inhibitors and potassium foods--nurses' knowledge. Int J Health Care Qual Assur. Feb 2014; 27(1):54-64. doi: 10.1108/IJHCQA-06-2012-0057. PMID: 24660518. DOI: https://doi.org/10.1108/IJHCQA-06-2012-0057
CAMPOS, Maria Teresa; MONTEIRO, Josefina; ORNELAS, Ana Paula. Fatores que afetam o consumo alimentar e a nutrição do idoso. Revista de Nutrição. Campinas, v. 13 n.3, Set/Dec. 2000. DOI: https://doi.org/10.1590/S1415-52732000000300002
CHRISTIE, Megaw; OLIVIER, Natascha; CORDIER, W. South African Dietitians’ Knowledge and Perceptions of Food-Drug Interactions and Factors Affecting It. Journal of Human Nutrition and Dietetics, v. 38, n. 1, 13 jan. 2025. DOI: https://doi.org/10.1111/jhn.70010
DENG, Jianyuan et al. A Review of Food-Drug Interactions on Oral Drug Absorption. PubMed. Drugs. 2017 Nov; 77(17):1833-1855. doi: 10.1007/s40265-017-0832-z. PMID: 29076109. DOI: https://doi.org/10.1007/s40265-017-0832-z
HELDT, Tatiane; LOSS, Sergio. Drug-nutrient interactions in the intensive care unit: literature review and current recommendations. Revista Brasileira de Terapia Intensiva, v. 25, n. 2, p. 162–167, jan. 2013. DOI: https://doi.org/10.5935/0103-507X.20130028
HORTA, Silvânia; COELHO, André Filipe. Interação medicamento-alimento: o que sabem os profissionais da farmácia e da nutrição? Acta Portuguesa de Nutrição, Portugal, v. 31, p. 38–42, 31 dez. 2022. DOI: https://doi.org/10.21011/apn.2022.3106
LEAL, Mayse Manuele; JÚNIOR, Janilson José. Interações fármaco nutriente: Caracterização e métodos inovadores de avaliação. Revista Rios Saúde, v. 208, p. 4, [s.d.], mar. 2018.
LOPES, Everton; CARVALHO, Rumão; FREITAS, Rivelilson. Análise das possíveis interações entre medicamentos e alimento/nutrientes em pacientes hospitalizados Analysis of possible food/nutrient and drug interactions in hospitalized patients. Artigo original Einstein, v. 8, n. 3, p. 298–302, set. 2010. DOI: https://doi.org/10.1590/s1679-45082010ao1672
LOPES, Everton et al. Interações fármaco-alimento/nutriente potenciais em pacientes pediátricos hospitalizados. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 34, n. 1, 1 jan. 2013.
MACEDO, Joyce et al. Interação droga-nutriente em pacientes pediátricos hospitalizados: uma revisão integrativa. Research, Society and Development, v. 9, n.1, e67911624, 2020, out. 2019. DOI: http://dx.doi.org/10.33448/rsd-v9i1.1624. DOI: https://doi.org/10.33448/rsd-v9i1.1624
MINATTO, Poliana. Possíveis repercussões no estado nutricional de um grupo de idosas que fazem uso de múltiplos fármacos. 2011. Pós Graduação em Gerontologia - Universidade do Extremo Sul Catarinense – UNESC, Criciúma, 2010.
MORLEY JE. Decreased food intake with aging. Journals Gerontol - Ser A Biol Sci
Med Sci. 56(SPEC. ISS. 2):81–8, Oct 2001.
MOURA, Mirian; REYES, Felix. Interação fármaco-nutriente: uma revisão. Revista de Nutrição, v. 15, n. 2, p. 223–238, ago. 2002. DOI: https://doi.org/10.1590/S1415-52732002000200011
OLIVEIRA, Ana Luísa; SANTOS, Jaqueline. Identificação de Interação desvantajosa Fármaco-Nutriente. ResearchGate, 2020. Disponível em: https://www.researchgate.net/profile/Jaqueline-Dos-Santos-4/publication/344956260_Identificacao_de_interacao_desvantajosa_farmaco-nutriente/links/5f9b1a2c92851c14bcf2cb68/Identificacao-de-interacao-desvantajosa-farmaco-nutriente.pdf
SANTOS, Sandna Larissa; BARROS, Karla Bruna; PRADO, Regilane. Interações entre fármacos e nutrientes: ocorrência e manejo clínico. Revista de Ciências Médicas e Biológicas, v. 17, n. 1, p. 61, 27 jun. 2018. DOI: https://doi.org/10.9771/cmbio.v17i1.16791
SILVA, Pollyanna Stéfany et al. Possíveis interações fármaco-nutrientes em crianças e idosos hospitalizados. Research, Society and Development, v. 9, n. 10, out. 2020. DOI: https://doi.org/10.33448/rsd-v9i10.9263
UNROE Kathleen et al. Inpatient medication reconciliation at admission and discharge: A retrospective cohort study of age and other risk factors for medication discrepancies. The American Journal of Geriatric Pharmacotherapy 8(2): 115–126, Apr. 2010. DOI: https://doi.org/10.1016/j.amjopharm.2010.04.002
VERNIZI Marcela; SILVA Lisiane. A prática de automedicação em adultos e idosos: uma revisão de literatura. Revista Saúde e Desenvolvimento, v. 10 n. 5, p. 10: 54–72, dez 2016.
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