DETERMINATION OF LANSOPRAZOLE IN CAPSULES USING METHODOLOGY BASED ON DIGITAL IMAGES.
DOI:
https://doi.org/10.61164/rmnm.v6i1.2488Keywords:
Titulação baseada em imagens digitais, potenciometria, lansoprazol, cápsulasAbstract
In this work, it is proposed to determine the content of lansoprazole, a selective inhibitor of gastric H+/K+-ATPase, using titration based on digital image (Digital Image-Based Titration). The DIB system uses a webcam to acquire digital images based on the RGB (Red-Green-Blue) color system. During the titration procedure, the method was applied to the acid-base titration of the drug lansoprazole with hydrochloric acid. Titration was performed by DIB and potentiometry. In the DIB methodology, for each volume of titrant added, an image was captured and manipulated to obtain the norm values (N=√R̅2+G̅2+B̅2). The volume of titrant used to reach the equivalence point was obtained from the second derivative of the titration curve. The results obtained from the samples did not show any significant statistical difference at the 95% confidence level, which was verified after applying the paired t-test (tcalculated = 0.439 and tcritical = 2.353). The relative standard deviations using the DIB methodology, with the exception of sample C, were below 1.0%.
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BOSCH, M. E; SÁNCHES, A. J. R; ROJAS, F. S; OJEDA, C.B. Analytical methodologies for the determination of omeprazole: an overview. Journal of Pharmaceutical and Biomedical, Espanha, v. 44, n. 4, p. 831-844, aug. 2007. DOI: https://doi.org/10.1016/j.jpba.2007.04.022
BYRNE, L. BARKER, J.; PENNARUN-THOMAS, G.; DIAMOND, D. Digital imaging as a detector for generic analytical measurements. Trends in analytical chemistry, Irlanda, v.19, n.8, p. 517-522, aug. 2000. DOI: https://doi.org/10.1016/S0165-9936(00)00019-4
CARDWELL, T. J.; CATTRALL, R. W.; CROSS, G. J.; O'CONNELL, G. R., PETTY, J. D.; SCOLLARY, G. R. Determination of titratable acidity of wines and total acidity of vinegars by discontinuous flow analysis using photometric end-point detection. Analyst, v. 116, n. 10, p. 1051-1054, 1991. DOI: https://doi.org/10.1039/an9911601051
COSTA, A. B.; CRUZ, D. R. N.; ALÉSSIO, K. O.; GARCIA, A. D.; ROTHMUND, K.; CARVALHO, F. S. BARIN, J. S.; TEDESCO, L. P. Aplicação da Termografia por Infravermelho para Titulações Termométricas. Orbital-The Electronic Journal of Chemistry, vol. 7, n. 2, p. 196-201, 2015. DOI: https://doi.org/10.17807/orbital.v7i2.682
EUROPEAN PHARMACOPOEIA. 7. ed. Strasbourg: Council of Europe, 2012.
FASS R, SHAPIRO M, DEKEL R, SEWELL J. Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease where next? Aliment Pharmacol Ther. 2005 Jul 15;22(2):79-94. DOI: https://doi.org/10.1111/j.1365-2036.2005.02531.x
FORGACS, I.; LOGANAYAGAM, A. Overprescribing próton pump inhibitors. British Medical Journal, Londres, n.7634, jan. 2008. DOI: https://doi.org/10.1136/bmj.39406.449456.BE
GAIÃO, E. N.; MARTINS, V. L.; LYRA, W. S.; SILVA, E. C.; ARAÚJO, M. C. U. Digital image-based titrations. Analytica Chimica Acta, Paraíba, v. 570, p. 283 290, jun. 2006. DOI: https://doi.org/10.1016/j.aca.2006.04.048
LIMA, M. B.; ANDRADE, S. I. E.; ALMEIDA, L. F. ARAÚJO, M. C. U. A digital image based micro-flow-batch analyzer. Microchemical Journal, v. 106, p. 238-243, jan. 2012. DOI: https://doi.org/10.1016/j.microc.2012.07.010
MOUSTAFA, A. A.M. Spectrophotometric methods for the determination of lansoprazole and pantoprazole sodium sesquihydrate. Journal of Pharmaceutical and Biomedical Analysis, v. 22, n.1 p. 45-58, feb. 2000. DOI: https://doi.org/10.1016/S0731-7085(99)00275-7
OHLWEILER, O. A. Fundamentos da Análise Instrumental. ed. LTC. Rio de Janeiro, 1981.
SACHS, G.; SHIN, J.M.; BRIVING, C.; WALLMARK, B.; HERSEY, S. The pharmacology of the gastric acid pump: the H+, K+ ATPase. Annual Review of Pharmacology and Toxicology, v. 35, n. 1, p. 277-305, 1995. DOI: https://doi.org/10.1146/annurev.pa.35.040195.001425
SCHMIDT JR, E; MELCHERT, W. R.; ROCHA, F. R. P. Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos. Química Nova, São Paulo, v. 34, n. 7, p. 1205-1210, mar. 2011. DOI: https://doi.org/10.1590/S0100-40422011000700019
SOHAILY, S.A., DUGGAN, A. Long term management of patients taking proton pump inhibitors. Australian Prescriber, Newcastle, n. 31, p. 5-7, 2008. DOI: https://doi.org/10.18773/austprescr.2008.005
STEDMAN, C. A. M.; BARCLAY, M. L. Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors. Aliment Pharmacol Ther, v. 14, n. 8, p. 963-978, 2000. DOI: https://doi.org/10.1046/j.1365-2036.2000.00788.x
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