EVALUATION OF THE CICATRICIAL RESPONSE OF NANOFIBERS LOADED WITH OZONIZED OIL IN DIRECT PULP CAPPING: A CLINICAL CASE REPORT

Authors

  • Maria Ritha Veiga Colognese Universidade Estadual do Oeste do Paraná
  • Bárbara Matthes Augsten Universidade Estadual do Oeste do Paraná (UNIOESTE)
  • Rafael Andrade Menolli Universidade Estadual do Oeste do Paraná (UNIOESTE)
  • Eduardo Tanaka Castro Universidade Estadual do Oeste do Paraná (UNIOESTE)
  • Julio Katuhide Ueda Universidade Estadual do Oeste do Paraná (UNIOESTE)
  • Veridiana Camilotti Universidade Estadual do Oeste do Paraná (UNIOESTE)

DOI:

https://doi.org/10.61164/a2956483

Keywords:

Pulpitis, Ozone Therapy, Nanofibers, Direct Pulp Capping

Abstract

Background: Direct pulp capping is a conservative procedure that aims to preserve the vitality of the dental pulp after exposure. Recent advances have explored the use of nanofibers loaded with ozonized oil for their regenerative and antimicrobial properties. Objectives: To report the clinical use of a nanofiber impregnated with ozonized sunflower oil as a direct pulp capping material, assessing clinical and radiographic responses and the impact on the patient’s quality of life. Case report: A clinical case was documented involving a 40-year-old female patient with reversible pulpitis in the lower right first molar. After controlled pulp exposure, the site was treated with nanofibers impregnated with ozonized sunflower oil and sealed with a bioactive adhesive system. Clinical and radiographic evaluations were performed at 7, 14, and 30 days, along with pain assessment using the Visual Analog Scale (VAS) and the OHIP-14 questionnaire to measure quality of life. Results: The patient experienced complete pain remission within 30 days, with restoration of normal pulp sensitivity and absence of periapical changes on radiographs. Clinical signs suggested pulp tissue repair, and the patient reported a marked improvement in oral health-related quality of life. Conclusions: The use of ozonized oil-loaded nanofibers as a direct pulp capping material showed favorable clinical outcomes and may represent a promising approach. However, further clinical studies are required to validate these preliminary findings. 

Downloads

Download data is not yet available.

References

ALGHAMDI, Abdulrahman A. et al. Assessment of the Micro-Tensile Bond Strength of a Novel Bioactive Dental Restorative Material (Surefil One). Polymers, v. 16, n. 11, 1 jun. 2024. DOI: https://doi.org/10.3390/polym16111558

ARUMUGAM, Mayakrishnan et al. Multifunctional silk fibroin and cellulose acetate composite nanofibers incorporated with palladium and platinum nanoparticles for enhanced wound healing: Comprehensive characterization and in vivo assessment. Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 684, 5 mar. 2024. DOI: https://doi.org/10.1016/j.colsurfa.2024.133153

CISTERNA, Barbara et al. Low ozone concentrations differentially affect the structural and functional features of non-activated and activated fibroblasts in vitro. International Journal of Molecular Sciences, v. 22, n. 18, 1 set. 2021. DOI: https://doi.org/10.3390/ijms221810133

CUSHLEY, S. et al. Efficacy of direct pulp capping for management of cariously exposed pulps in permanent teeth: a systematic review and meta-analysis. International Endodontic Journal, v. 54, n. 4, p. 556–571, 1 abr. 2021. DOI: https://doi.org/10.1111/iej.13449

GIRAUD, Thomas et al. Pulp capping materials modulate the balance between inflammation and regeneration. Dental Materials, v. 35, n. 1, p. 24–35, 1 jan. 2019. DOI: https://doi.org/10.1016/j.dental.2018.09.008

HOSEINIFAR, Razieh et al. Histological Evaluation of Human Pulp Response to Direct Pulp Capping with MTA, CEM Cement, and Biodentine. Journal of Dentistry (Shiraz, Iran), v. 21, n. 3, p. 177–183, set. 2020.

LACERDA, Adrienne Coelho et al. Efficacy of biostimulatory ozone therapy: Case report and literature review. Journal of Cosmetic Dermatology, v. 21, n. 1, p. 130–133, 1 jan. 2022. DOI: https://doi.org/10.1111/jocd.14079

LIU, Liyao et al. Ozone therapy for skin diseases: Cellular and molecular mechanisms. International Wound Journal, v. 20, n. 6, p. 2376–2385, 1 ago. 2023. DOI: https://doi.org/10.1111/iwj.14060

PALMA, Paulo J. et al. Effect of restorative timing on shear bond strength of composite resin/calcium silicate–based cements adhesive interfaces. Clinical Oral Investigations, v. 25, n. 5, p. 3131–3139, 1 maio 2021. DOI: https://doi.org/10.1007/s00784-020-03640-7

PATEL, Kapil D. et al. Coating biopolymer nanofibers with carbon nanotubes accelerates tissue healing and bone regeneration through orchestrated cell- and tissue-regulatory responses. Acta Biomaterialia, v. 108, p. 97–110, 1 maio 2020. DOI: https://doi.org/10.1016/j.actbio.2020.03.012

PRASERTSUKSOM, Nattawut et al. Treatment Outcomes and Prognostic Factors of Direct Pulp Capping in Permanent Teeth: A Systematic Review and Meta-analysis. European Endodontic Journal, v. 9, n. 4, p. 295–307, 2024. DOI: https://doi.org/10.14744/eej.2024.93723

RASOULI, Rahimeh et al. Nanofibers for Biomedical and Healthcare Applications. Macromolecular Bioscience, v. 19, n. 2, 1 fev. 2019. DOI: https://doi.org/10.1002/mabi.201800256

RICUCCI, Domenico et al. Outcome of Direct Pulp Capping Using Calcium Hydroxide: A Long-term Retrospective Study. Journal of Endodontics, v. 49, n. 1, p. 45–54, 1 jan. 2023. DOI: https://doi.org/10.1016/j.joen.2022.11.005

SABRA, Sally et al. Recent advances in electrospun nanofibers for some biomedical applications. European Journal of Pharmaceutical Sciences, v. 144, 1 mar. 2020. DOI: https://doi.org/10.1016/j.ejps.2020.105224

SETHURAM, Lakshimipriya; THOMAS, John. Therapeutic applications of electrospun nanofibers impregnated with various biological macromolecules for effective wound healing strategy – A review. Biomedicine and Pharmacotherapy, v. 157, 1 jan. 2023. DOI: https://doi.org/10.1016/j.biopha.2022.113996

VALACCHI, G.; FORTINO, V.; BOCCI, V. The dual action of ozone on the skin. British Journal of Dermatology, v. 153, n. 6, p. 1096–1100, dez. 2005. DOI: https://doi.org/10.1111/j.1365-2133.2005.06939.x

WUERSCHING, Sabina Noreen et al. Assessing the marginal seal of bioactive restorative materials in class II cavities with a bacterial penetration model. Dental Materials, v. 41, n. 5, p. 553–560, 1 maio 2025. DOI: https://doi.org/10.1016/j.dental.2025.03.003

YANG, Yutong et al. Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing. Advanced Fiber Materials, v. 4, n. 5, p. 1027–1057, 1 out. 2022. DOI: https://doi.org/10.1007/s42765-022-00178-z

YANTCHEVA, Sevda Mihailova. Marginal adaptation and micropermeability of class II cavities restored with three different types of resin composites—a comparative ten-month in vitro study. Polymers, v. 13, n. 10, 2 maio 2021. DOI: https://doi.org/10.3390/polym13101660

ZHENG, Zesen et al. Recent advances in structural and functional design of electrospun nanofibers for wound healing. Journal of Materials Chemistry B, v. 13, n. 18, p. 5226–5263, 1 abr. 2025. DOI: https://doi.org/10.1039/D4TB02718C

Downloads

Published

2025-09-15

Issue

Vol. 17 No. 1 (2025): REMUNOM - ISSN 2178-6925

Section

Artigos

License

Copyright (c) 2025 Revista Multidisciplinar do Nordeste Mineiro

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Autores que publicam nesta revista concordam com os seguintes termos:
 

  • Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista;
  • Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista, desde que adpatado ao template do repositório em questão;
  • Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado (Veja O Efeito do Acesso Livre).
  • Os autores são responsáveis por inserir corretamente seus dados, incluindo nome, palavras-chave, resumos e demais informações, definindo assim a forma como desejam ser citados. Dessa forma, o corpo editorial da revista não se responsabiliza por eventuais erros ou inconsistências nesses registros.

 

POLÍTICA DE PRIVACIDADE

Os nomes e endereços informados nesta revista serão usados exclusivamente para os serviços prestados por esta publicação, não sendo disponibilizados para outras finalidades ou a terceiros.

Obs: todo o conteúdo do trabalho é de responsabilidade do autor e orientador.

How to Cite

EVALUATION OF THE CICATRICIAL RESPONSE OF NANOFIBERS LOADED WITH OZONIZED OIL IN DIRECT PULP CAPPING: A CLINICAL CASE REPORT. (2025). Revista Multidisciplinar Do Nordeste Mineiro, 17(1), 1-17. https://doi.org/10.61164/a2956483