CORRELATION BETWEEN GUT MICROBIOTA AND ENDOMETRIOSIS: THE ROLE OF THE LOW FODMAP DIET

Authors

  • Izabely Tayanni Luiz Feitosa Centro Universitário Mario Pontes Jucá
  • Palloma Krishna Araujo Alves Costa Centro Universitário Mário Pontes Jucá

DOI:

https://doi.org/10.61164/qv5a0631

Keywords:

Endometriosis, Gut microbiota, Low FODMAP diet

Abstract

Costa, P. K. A. A. Feitosa I. T. L. Correlation between the Gut Microbiota and Endometriosis: The role of the Low FODMAP diet. 2025. 50p. Undergraduate Thesis (Nutrition) – Mario Pontes Jucá University Center, Maceió, 2025.

Endometriosis is a chronic inflammatory disease that affects women of reproductive age. Recent studies suggest that alterations in the gut microbiota can intensify inflammatory and immunological responses, contributing to the worsening of disease symptoms. In this context, the Low FODMAP diet, originally developed for the management of irritable bowel syndrome, has been studied as an alternative to modulate the gut microbiota and reduce gastrointestinal symptoms associated with endometriosis. This work aims to investigate, through a literature review, the relationship between gut microbiota and endometriosis, as well as to evaluate the potential of the Low FODMAP diet in relieving gastrointestinal symptoms. Articles published between 2018 and 2025, selected from the PubMed, SciELO, Scopus, and Web of Science databases, were considered. The results indicate that the Low FODMAP diet can contribute to the reduction of symptoms such as abdominal pain and bloating, provided that its application is individualized and monitored by a nutritionist. It is important to note that prolonged use of this dietary strategy can reduce intestinal bacterial diversity, requiring caution in its use. Modulation of the microbiota through the Low FODMAP diet shows promise as an approach in managing gastrointestinal symptoms related to endometriosis.

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References

MARTINS, A.; PEQUITO, A.; BALTAZAR, A. L.

Disbiose intestinal e síndrome do intestino irritável: efeito de uma dieta baixa em FODMAPs.Acta Portuguesa de Nutrição, n. 22, p. 38–41, 2020. Disponível em: http://www.scielo.pt/scielo.php?script=sci_arttext&pid=S2183-59852020000300007.

FRANCO, Tamires Santos; XAVIER, Raíra dos Santos; MEDEIROS, Isabela Jacinto; LAMARCA, Raphaela Paciello de Souza; FARIAS, Lavinia Santos; SILVEIRA, Kelly Paiva Guimarães. ENDOMETRIOSE: MANIFE6STAÇÕES MULTISSISTÊMICAS, CAUSAS, ABORDAGENS TERAPÊUTICAS E OS SEU IMPACTO NA SAÚDE FEMININA. Revista Ibero-Americana de Humanidades, Ciências e Educação, [S. l.], v. 11, n. 1, p. 420–426, 2025. DOI: 10.51891/rease.v11i1.17739. Disponível em: https://periodicorease.pro.br/rease/article/view/17739. Acesso em: 01 nov. 2025..

QIN, Rui et al. The gut microbiota and endometriosis: from pathogenesis to diagnosis and treatment. Frontiers in Cellular and Infection Microbiology, v. 12, 2022. DOI: 10.3389/fcimb.2022.1069557. Disponível em: https://www.frontiersin.org/articles/10.3389/fcimb.2022.1069557/full

. Acesso em: 01 nov. 2025.

Varney, J.E., So, D., Gibson, P.R., Rhys-Jones, D., Lee, Y.S.J., Fisher, J., Moore, J.S., Ratner, R., Morrison, M., Burgell, R.E. e Muir, J.G. (2025), Ensaio Clínico: Efeito de uma dieta baixa em FODMAP de 28 dias nos sintomas gastrointestinais associados à endometriose (EndoFOD) — Um estudo randomizado e controlado de alimentação cruzada. Aliment Pharmacol Ther, 61: 1889-1903. https://doi.org/10.1111/apt.70161

MOORE, Judith S.; GIBSON, Peter R.; PERRY, Richard E.; BURGELL, Rebecca E. Endometriosis in patients with irritable bowel syndrome: specific symptomatic and demographic profile, and response to the low FODMAP diet. Australian & New Zealand Journal of Obstetrics & Gynaecology, v. 57, n. 2, p. 201–205, Apr. 2017. DOI: 10.1111/ajo.12594. Disponível em: https://doi.org/10.1111/ajo.12594. Acesso em: 07 nov. 2025

ALVES, Laryssa Sobral, DOS SANTOS, Gabriela Vasques; MENDES, Giovana Alves Marques et al. As repercussões da endometriose na qualidade de vida das mulheres Brasileiras. Revista Sociedade Científica, vol.8, n. 1, p.600-616, 2025. https://doi.org/10.61411/rsc202598818

VIGANÒ, P.; CANDIANI, M.; MONNO, A.; GIACOMINI, E.; VERCELLINI, P.; SOMIGLIANA, E. Time to redefine endometriosis including its pro-fibrotic nature. Human Reproduction, v. 33, n. 3, p. 347–352, 2018. DOI: 10.1093/humrep/dey003 Disponível em: https://imf.primo.exlibrisgroup.com/discovery/fulldisplay/cdi_proquest_miscellaneous_1973458493/01TIMF_INST:Shared

LEONARDI, M.; HOCKE, C.; ARMSTRONG, S.; et al. Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature. Diagnostics, v. 14, n. 3, p. 312, 2021. DOI: 10.3390/diagnostics14030312 Disponível em: MDPI Diagnostics

GAUDIO, A.; SVENSSON, A.; BRUNKWALL, L.; ROTH, B.; ORHO-MELANDER, M.; OHLSSON, B. Associations Between Endometriosis and Gut Microbiota. Reproductive Sciences, v. 28, p. 2367–2377, 2021. DOI: 10.1007/s43032-021-00506-5 Disponível em: Springer Reproductive Sciences.

VALDES, A. M.; WALTER, J.; SEGAL, E.; SPECTOR, T. D. Role of the gut microbiota in nutrition and health. BMJ, v. 361, k2179, 2018. DOI: 10.1136/bmj.k2179. Disponível em: https://www.bmj.com/content/361/bmj.k2179 .

HOU, L.; ZHANG, J.; LI, H.; et al. Gut microbiota in health and disease. Signal Transduction and Targeted Therapy, v. 7, n. 1, p. 135, 2022. DOI: 10.1038/s41392-022-00974-3 Disponível em: https://www.nature.com/articles/s41392-022-00974-3

WALLENBORN, J.; VON MÜHLENBROCK, M.; et al. The role of intestinal microbiota in gynecological diseases: endometriosis as a model condition. International Journal of Molecular Sciences, v. 23, n. 21, p. 13245, 2022. DOI: 10.3390/ijms232113245 Disponível em: https://www.mdpi.com/1422-0067/23/21/13245.

MARTINS, Ana; PEQUITO, Ana; BALTAZAR, Ana Lúcia. Intestinal Dysbiosis and Irritable Bowel Syndrome: effect of a low diet on FODMAPs. Acta Portuguesa de Nutrição, n. 22, p. 38–41, 2020. Disponível em: https://scielo.pt/scielo.php?script=sci_abstract&pid=S2183-59852020000300007&lng=en&nrm=iso.

BAKER, J. M.; AL-NAKOUZI, A.; HUSSAIN, T.; HARRIS, R. A. Gut microbiome and sex hormone metabolism. BMC Biology, v. 15, n. 1, p. 59, 2017. DOI: 10.1186/s12915-017-0411-5 Disponível em: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0411-5.

KINASHI, Y.; HASE, K. Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity. Frontiers in Immunology, v. 12, 2021. DOI: 10.3389/fimmu.2021.673708 Disponível em: Frontiers.

LI, Y.; WANG, H.; ZHOU, Q.; et al. Research progress on the correlation between microbiota and endometriosis. European Journal of Obstetrics & Gynecology and Reproductive Biology, v. 295, p. 45–53, 2025. DOI: 10.1016/j.ejogrb.2025.09.047 Disponível em: Elsevier.

WANG, M.; LIU, W.; ZHENG, L.; MA, S.; JIN, L.; ZHAO, D.; LI, D. Broadening horizons: microbiota as a novel biomarker and potential treatment for endometriosis. Frontiers in Microbiology, v. 16, 2025. DOI: 10.3389/fmicb.2025.1521216 Disponível em: Frontiers.

HALMOS, E. P.; POWER, V. A.; SHEPHERD, S. J.; GIBSON, P. R.; MOSHFEGH, A. J. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology, v. 146, n. 1, p. 67–75, 2014. DOI: 10.1053/j.gastro.2013.09.046.

STAUDACHER, H. M.; WHELAN, K.Nutritional, microbiological and psychosocial implications of the low FODMAP diet.Journal of Gastroenterology and Hepatology, v. 32, n. 1, p. 15–26, 2017. DOI: 10.1111/jgh.13688

KEUKENS, A.; VETH, V. B.; VAN DE KAR, M. M. A.; et al. Effects of a low-FODMAP diet on patients with endometriosis: a prospective cohort study. BMC Women’s Health, v. 25, artigo 174, 2025.

DOI: 10.1186/s12905-025-03715-1.

Baușic, AIG, Scurtu, F., Manu, A., Matasariu, DR, & Brătilă, E. (2025). Disbiose da microbiota intestinal na endometriose: uma possível ligação com a inflamação e a progressão da doença. International Journal of Molecular Sciences , 26 (11), 5144. https://doi.org/10.3390/ijms26115144.

HALMOS, E. P.; CHRISTOPHERSEN, C. T.; BIRD, A. R.; SHEPHERD, S. J.; GIBSON, P. R.; MUIR, J. G. Diets that differ in their FODMAP content alter the colonic luminal microenvironment. Gut, v. 64, n. 1, p. 93–100, 2015. Disponível em: https://gut.bmj.com/content/gutjnl/64/1/93.full.pdf.

Whelan, K.; Martin, L. D.; Staudacher, H. M.; Lomer, M. C. E. (2018). The low FODMAP diet in the management of irritable bowel syndrome: an evidence-based review of FODMAP restriction, reintroduction and personalisation in clinical practice. Journal of Human Nutrition and Dietetics, 31(2), 239–255. DOI: 10.1111/jhn.12530.

Published

2025-12-05

How to Cite

CORRELATION BETWEEN GUT MICROBIOTA AND ENDOMETRIOSIS: THE ROLE OF THE LOW FODMAP DIET. (2025). Revista Multidisciplinar Do Nordeste Mineiro, 21(01), 1-13. https://doi.org/10.61164/qv5a0631