GENES HLA E RESPOSTA VACINAL: UMA REVISÃO NARRATIVA
DOI:
https://doi.org/10.61164/53z6tt45Palabras clave:
Sistema HLA, polimorfismo genético, resposta vacinal, imunogenéticaResumen
Introdução: O sistema HLA é essencial na resposta imune às vacinas, pois apresenta antígenos e ativa linfócitos. Sua grande variabilidade genética explica diferenças de eficácia vacinal entre indivíduos e populações. Objetivo: Avaliar a influência dos polimorfismos do HLA na resposta imunológica a vacinas, identificando alelos associados à boa resposta ou falhas vacinais. Metodologia: Revisão integrativa da literatura (2015–2025) nas bases PubMed, SciELO e Web of Science, incluindo artigos originais e revisões sobre HLA e resposta vacinal em humanos. Resultados e discussão: Alelos como HLA-DRB115 e HLA-DQB106 foram associados a respostas robustas contra hepatite B e influenza, enquanto HLA-DRB103 e HLA-DQB102 relacionaram-se à hiporresponsividade a vacinas como a tríplice viral e a alguns imunizantes contra COVID-19. Diferenças na apresentação antigênica das classes I e II afetam a imunidade humoral e celular, e a frequência alélica varia entre regiões. Considerações finais: A diversidade genética do HLA influencia fortemente a resposta vacinal, indicando a necessidade de estratégias imunogenéticas personalizadas.
Descargas
Referencias
ABBAS, A. K.; LICHTMAN, A. H.; PILLAI, S. Imunologia celular e molecular. 10. ed. Rio de Janeiro: Elsevier, 2021.
ABEDINI, F. et al. Diversity of HLA class I and class II alleles in Iran populations: systematic review and meta-analysis. Transplant Immunology, [S.l], v. 69, p. 101472, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34555503/. Acesso em: 20 ago. 2025. DOI: https://doi.org/10.1016/j.trim.2021.101472
ABUALROUS, E. T. et al. Major histocompatibility complex (MHC) class I and class II proteins: impact of polymorphism on antigen presentation. Current Opinion in Immunology, [S.l], v. 70, p. 95-104, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34052735/. Acesso em: 06 jun. 2025. DOI: https://doi.org/10.1016/j.coi.2021.04.009
AFLALO, A.; BOYLE, L. H. Polymorphisms in MHC class I molecules influence their interactions with components of the antigen processing and presentation pathway. International Journal of Immunogenetics, Oxford, England, v. 48, n. 4, p. 317-325, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34176210/. Acesso em: 20 ago. 2025. DOI: https://doi.org/10.1111/iji.12546
ALONSO, G. T. et al. Linfócitos T auxiliares foliculares humanos: células essenciais para a resposta de anticorpos. Einstein, São Paulo, v. 19, eRB6077, 2021. Disponível em: https://www.scielo.br/j/eins/a/5FVnw3RwdFkHTxX5qLXVthH/?lang=pt&format=pdf. Acesso em: 6 jun. 2025.
BOQUETT, J. A. et al. HLA diversity in Brazil. HLA, [S.l.], v. 95, p. 3–14, 2019. DOI: https://doi.org/10.1111/tan.13723
CARRYN, St. et al. Long-term immunogenicity of measles, mumps and rubella-containing vaccines in healthy young children: a 10-year follow-up. Vaccine, [S.l.], v. 37, n. 36, p. 5323-5331, 2019. Disponível ema; https://pubmed.ncbi.nlm.nih.gov/31345639/. Acesso em: 20 ago. 2025. DOI: https://doi.org/10.1016/j.vaccine.2019.07.049
COWLING, B. J.; OKOLI, G. N. Influenza vaccine effectiveness and progress towards a universal influenza vaccine. Drugs, [S.l.], v. 84, n. 9, p. 1013-1023, 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/39167316/. Acesso em: 06 jun. 2025. DOI: https://doi.org/10.1007/s40265-024-02083-8
CROTTY, S. T follicular helper cell biology: A decade of discovery and diseases. Immunity, [S.l.], v. 50, n. 5, p. 1132–1148, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31117010/. Acesso em: 27 maio 2025. DOI: https://doi.org/10.1016/j.immuni.2019.04.011
FABRETI-OLIVEIRA, R. A. et al. The heterogeneous HLA genetic composition of the Brazilian population and its relevance to the optimization of hematopoietic stem cell donor recruitment. Tissue Antigens, [S.l.], v. 84, n. 1, p. 187–197, 2014. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24724906/. Acesso em: 20 ago. 2025. DOI: https://doi.org/10.1111/tan.12352
FAKHKHARI, M.; CAIDI, H.; SADKI, K. HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review. Egyptian Journal of Medical Human Genetics, Cairo, Egito, v. 24, n. 1, p. 10, 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36710951/. Acesso em: 20 ago. 2025. DOI: https://doi.org/10.1186/s43042-023-00390-5
FERNANDES, A. P. M. et al. Bases da imunologia. São Paulo: Atheneu, 2003.
JANEWAY, C. A. et al. Imunobiologia. 9. ed. Porto Alegre: Artmed, 2017.
KAWASHIMA, Y. et al. Adaptation of HIV-1 to human leukocyte antigen class I. Nature Reviews Immunology, Hangzhou, China, v. 458, n. 7238, p. 641-645, 2009. Disponível em: https://pubmed.ncbi.nlm.nih.gov/19242411/. Acesso em: 27 maio 2025. DOI: https://doi.org/10.1038/nature07746
LIMA-JÚNIOR, J. C. et al. Influence of HLA-DRB1 and HLA-DQB1 Alleles on IgG Antibody Response to the P. vivax MSP-1, MSP-3a and MSP-9 in Individuals from Brazilian Endemic Area. PLoS ONE, San Francisco, EUA, v. 7, n. 5, e36419, 2012. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036419. Acesso em: 05 maio 2025. DOI: https://doi.org/10.1371/journal.pone.0036419
MIGLIORINI, F. et al. Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature. European Journal of Medical Research,[S.l.], v. 26, n. 1, p. 84, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34344463/. Acesso em: 27 maio 2025. DOI: https://doi.org/10.1186/s40001-021-00563-1
OU, G. et al. HLA-DPB1 alleles in hepatitis B vaccine response: a meta-analysis. Medicine, Baltimore, EUA, v. 100, n. 14, p. e24904, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33832070/. Acesso em: 18 jun. 2025. DOI: https://doi.org/10.1097/MD.0000000000024904
OVSYANNIKOVA, I. G. et al. A large population-based association study between HLA and KIR genotypes and measles vaccine antibody responses. PLoS ONE, San Francisco, EUA,, v. 12, n. 2, e0171261, 2017. Disponível em: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171261&type=printable. Acesso em: 20 ago. 2025. DOI: https://doi.org/10.1371/journal.pone.0171261
OVSYANNIKOVA, I. G. et al. HLA genotypes and rubella vaccine immune response: additional evidence. Vaccine, [S.l.], v. 32, n. 33, p. 4206-4213, 2014. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC4124933/. Acesso em: 20 ago. 2025. DOI: https://doi.org/10.1016/j.vaccine.2014.04.091
PETERS, B. et al. T Cell Epitope Predictions. Annual Review of Immunology, [S.l.], v. 38, n. 1, p. 83–104, 2020. Disponível em: https://www.annualreviews.org/content/journals/10.1146/annurev-immunol-082119-124838. Acesso em: 18 jun. 2025. DOI: https://doi.org/10.1146/annurev-immunol-082119-124838
PISHESHA, N. et al. A guide to antigen processing and presentation. Nature Reviews Immunology, Hangzhou, China, v. 22, n. 12, p. 751-764, 2022. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35418563/. Acesso em: 27 maio 2025. DOI: https://doi.org/10.1038/s41577-022-00707-2
POLAND, G. A.; OVSYANIKOVA, I. G.; KENNEDY, R. B. Personalized vaccinology: A review. Vaccine, [S.l.], v. 36, n. 36, p. 5350–5357, 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28774561/. Acesso em: 27 maio 2025. DOI: https://doi.org/10.1016/j.vaccine.2017.07.062
SACO, T. V. et al. Hepatitis B vaccine nonresponders: possible mechanisms and solutions. Annals of Allergy, Asthma & Immunology, Colombus, EUA, v. 121, n. 3, p. 320-327, set. 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29567355/. Acesso em: 25 maio 2025. DOI: https://doi.org/10.1016/j.anai.2018.03.017
SAKAI, A. et al. Identification of amino acids in antigen-binding site of class II HLA proteins independently associated with hepatitis B vaccine response. Vaccine, [S.l.], v. 35, n. 47, p. 703-710, 2017. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28043736/. Acesso em: 25 maio 2025. DOI: https://doi.org/10.1016/j.vaccine.2016.08.068
SIEGRIST, C. A. Vaccine immunology. In: ORENSTEIN, W. A. et al. Plotkin’s Vaccines. 7. ed. Rio de Janeiro: Elsevier, 2018, p. 16-34. DOI: https://doi.org/10.1016/B978-0-323-35761-6.00002-X
SETTE, A.; CROTTY, S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell, [S.l.], v. 184, n. 4, p. 861–880, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33497610/. Acesso em: 25 maio 2025. DOI: https://doi.org/10.1016/j.cell.2021.01.007
SONON, P. et al. Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children. Infection, Genetics and Evolution, [S.l.], v. 92, p. 104828, 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S1567134821001258?via%3Dihub. Acesso em: 18 jun. 2025. DOI: https://doi.org/10.1016/j.meegid.2021.104828
TERAJIMA, M. et al. Identification of vaccinia CD8+ T-cell epitopes conserved among vaccinia and variola viruses restricted by common MHC class I molecules, HLA-A2 or HLA-B7. Human Immunology, Arlington, EUA, v. 67, n. 7, p. 512-520, 2006. Disponível em: https://pubmed.ncbi.nlm.nih.gov/16829305/. Acesso em: 18 jun. 2025. DOI: https://doi.org/10.1016/j.humimm.2005.12.004
TERAJIMA, M. et al. Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses. The Journal of Experimental Medicine, [S.l.], v. 197, n. 7, p. 927-932, 2003. Disponível em: https://pubmed.ncbi.nlm.nih.gov/12668642/. Acesso em: 25 maio 2025. DOI: https://doi.org/10.1084/jem.20022222
TUKWASIBWE, S. et al. Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity. Malaria Journal, [S.l.], v. 20, n. 1, p. 111, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33632228/. Acesso em: 18 jun. 2025. DOI: https://doi.org/10.1186/s12936-021-03652-y
WANG, L. et al. Response to hepatitis B vaccination is co-determined by HLA-DPA1 and -DPB1. Vaccine, [S.l.], v. 37, n. 43, p. 6435–6440, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31515149/. Acesso em: 18 jun. 2025. DOI: https://doi.org/10.1016/j.vaccine.2019.09.001
YEWDELL, J. W.; BENNINK, J. R. Immunodominance in major histocompatibility complex class I–restricted T lymphocyte responses. Annual Review of Immunology, [S.l.], v. 39, p. 395–419, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/10358753/. Acesso em: 20 ago. 2025.
ZHANG, L. et al. Human leukocyte antigen (HLA) class I and II genetic relationships with brain imaging measures: a systematic review and meta-analysis. Brain, Behavior and Immunity, New Orleans, USA, v. 128, p. 336–351, 2025. Disponível em: https://pubmed.ncbi.nlm.nih.gov/40222562/. Acesso em: 20 ago. 2025. DOI: https://doi.org/10.1016/j.bbi.2025.04.011
ZHANG, Y. et al. The link between genetic variation and variability in vaccine responses: a narrative review. Journal of Bio-X Research, , [S.l.], v. 5, p. 49-54, 2022. Disponível em: https://spj.science.org/doi/10.1097/JBR.0000000000000122. Acesso em: 25 maio 2025. DOI: https://doi.org/10.1097/JBR.0000000000000122
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2025 Revista Multidisciplinar do Nordeste Mineiro
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Authors who publish in this journal agree to the following terms:
Authors retain copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which permits the sharing of the work with proper acknowledgment of authorship and initial publication in this journal;
Authors are authorized to enter into separate, additional agreements for the non-exclusive distribution of the version of the work published in this journal (e.g., posting in an institutional repository or publishing it as a book chapter), provided that authorship and initial publication in this journal are properly acknowledged, and that the work is adapted to the template of the respective repository;
Authors are permitted and encouraged to post and distribute their work online (e.g., in institutional repositories or on their personal websites) at any point before or during the editorial process, as this may lead to productive exchanges and increase the impact and citation of the published work (see The Effect of Open Access);
Authors are responsible for correctly providing their personal information, including name, keywords, abstracts, and other relevant data, thereby defining how they wish to be cited. The journal’s editorial board is not responsible for any errors or inconsistencies in these records.
PRIVACY POLICY
The names and email addresses provided to this journal will be used exclusively for the purposes of this publication and will not be made available for any other purpose or to third parties.
Note: All content of the work is the sole responsibility of the author and the advisor.
