APLICAÇÕES DE BIOMARCADORES ENZIMÁTICOS EM DOENÇAS CARDIOVASCULARES
DOI:
https://doi.org/10.61164/1k6q2921Keywords:
Biomarcadores enzimáticos; Doenças cardiovasculares; Troponina; BNP; Diagnóstico precoce; Medicina personalizada.Abstract
Cardiovascular diseases remain the leading cause of mortality worldwide, demanding increasingly accurate diagnostic strategies. In this context, enzymatic biomarkers have become essential tools in clinical practice, enabling the identification of myocardial injury, risk stratification, and therapeutic monitoring. This article discusses the historical evolution of biomarkers, from classical enzymes such as CK-MB and LDH to modern markers like high-sensitivity troponins and natriuretic peptides (BNP and NT-proBNP). Their clinical applications, technological advances, limitations, and future perspectives are analyzed, emphasizing the role of biomarkers in personalized and preventive medicine.
Downloads
References
DATASUS. Mortalidade por Doenças do Aparelho Circulatório no Brasil. Ministério da Saúde, 2023. Disponível em: http://datasus.saude.gov.br.
Januzzi, J. L.; Mebazaa, A.; Di Somma, S.; et al. Novel Biomarkers in Cardiovascular Disease: Galectin-3, ST2 and Beyond. Circulation Research, v. 134, n. 2, p. 201–215, 2024.
Maisel, A. S.; Daniels, L. B.; Breidthardt, T.; et al. BNP and NT-proBNP in Heart Failure Diagnosis and Management. Journal of the American College of Cardiology (JACC), v. 81, n. 12, p. 1125–1138, 2023.
Mueller, C.; Giannitsis, E.; Christ, M.; et al. Biomarkers in Acute Coronary Syndromes and Heart Failure: Current Evidence and Future Perspectives. Nature Reviews Cardiology, v. 21, p. 123–139, 2024.
McDonagh, T. A.; Metra, M.; Adamo, M.; et al. 2023 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure. European Heart Journal, v. 44, n. 4, p. 359–419, 2023.
Thygesen, K.; Alpert, J. S.; Jaffe, A. S.; et al. Fourth Universal Definition of Myocardial Infarction (2023). European Heart Journal, v. 44, n. 3, p. 239–269, 2023.
World Health Organization (WHO). Cardiovascular Diseases Fact Sheet. Geneva: WHO, 2024. Disponível em: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds). Acessado em 04 dez. 2025.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 André Gomes de Lima
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
Authors retain copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which permits the sharing of the work with proper acknowledgment of authorship and initial publication in this journal;
Authors are authorized to enter into separate, additional agreements for the non-exclusive distribution of the version of the work published in this journal (e.g., posting in an institutional repository or publishing it as a book chapter), provided that authorship and initial publication in this journal are properly acknowledged, and that the work is adapted to the template of the respective repository;
Authors are permitted and encouraged to post and distribute their work online (e.g., in institutional repositories or on their personal websites) at any point before or during the editorial process, as this may lead to productive exchanges and increase the impact and citation of the published work (see The Effect of Open Access);
Authors are responsible for correctly providing their personal information, including name, keywords, abstracts, and other relevant data, thereby defining how they wish to be cited. The journal’s editorial board is not responsible for any errors or inconsistencies in these records.
PRIVACY POLICY
The names and email addresses provided to this journal will be used exclusively for the purposes of this publication and will not be made available for any other purpose or to third parties.
Note: All content of the work is the sole responsibility of the author and the advisor.
