ACOUSTIC-ELASTIC MEASUREMENTS OF ABSORBED DOSE USING POLYMER GEL DOSIMETER AS SOFT TISSUE-MIMICKING MATERIAL
DOI:
https://doi.org/10.61164/m6f2q231Keywords:
Ultrasound, Speed of sound, Attenuation coefficient, Young's modulus, Absorved dose, Polymer gel dosimeterAbstract
Accurate absorbed dose dosimetry is a key factor for the effectiveness and safety of radiotherapy treatments, particularly when three-dimensional dose verification is required. In this context, polymer gel dosimeters stand out for their ability to record volumetric dose distributions, traditionally read using magnetic resonance imaging, a high-cost technique with limited clinical availability. This study investigates the applicability of an ultrasonic system as an alternative method for reading MAGIC-F polymer gel dosimeters used in radiotherapy. Initially, the system was calibrated using homogeneous gelatin-based samples with different concentrations, evaluating the response of ultrasonic velocity, attenuation coefficient, and elastic moduli. Subsequently, the methodology was applied to MAGIC-F gel samples irradiated with absorbed doses ranging from 0 to 40 Gy. Longitudinal ultrasonic velocity and attenuation coefficient were experimentally determined using the transmission–reception technique, while elastic moduli were estimated based on empirical relations supported by the literature. The results indicate an approximately linear attenuation behavior between 0 and 30 Gy, with a more pronounced variation at higher doses, suggesting distinct material response regimes. A systematic increase in mechanical stiffness with dose was also observed, as evidenced by the increase in Young’s modulus. These findings demonstrate the potential of ultrasound as a complementary tool for three-dimensional absorbed dose readout in polymer gel dosimetry.
Downloads
References
ALVES, N.; KIM, A.; TAN, J.; HWANG, G.; JAVED, T.; NEAGU, B.; COURTNEY, B. K. Cardiac tissue-mimicking ballistic gel phantom for ultrasound imaging in clinical and research applications. Ultrasound in Medicine & Biology, v. 46, n. 8, p. 2057–2069, 2020. Disponível em: https://doi.org/10.1016/j.ultrasmedbio.2020.03.017.
AULD, B. A. Acoustic fields and waves in solids. New York: John Wiley & Sons, 1973.
BADAWE, H. M. et al. High-resolution acoustic mapping of tunable gelatin-based soft phantoms. Frontiers in Bioengineering and Biotechnology, v. 12, 1276143, 2024. Disponível em: https://doi.org/10.3389/fbioe.2024.1276143.
BALDOCK, C. et al. Polymer gel dosimetry. Physics in Medicine & Biology, v. 66, n. 12, 2021. Disponível em: https://doi.org/10.1088/1361-6560/ac0d78.
BRAY, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, v. 74, n. 3, p. 229–263, 2024. Disponível em: https://doi.org/10.3322/caac.21708.
CAFARELLI, A. et al. Tuning acoustic and mechanical properties of materials for ultrasound phantoms and smart substrates for cell cultures. Acta Biomaterialia, v. 49, p. 368–378, 2017. Disponível em: https://doi.org/10.1016/j.actbio.2016.11.036.
CAVEDINI, N. G. et al. Dose sensitivity of MAGIC-F polymer gel using different MRI sequences. Brazilian Journal of Radiation Sciences, v. 10, n. 4, p. 1–15, 2022. Disponível em: https://doi.org/10.15392/bjrs.v10i4.1732.
CRESCENTI, R. A.; BAMBER, J. C.; BUSH, N. L.; WEBB, S. Characterization of dose-dependent Young’s modulus for a radiation-sensitive polymer gel. Physics in Medicine & Biology, v. 52, n. 22, p. 665–676, 2007. Disponível em: https://doi.org/10.1088/0031-9155/52/22/021.
DE DEENE, Y. Radiation dosimetry by use of radiosensitive hydrogels. Polymers, v. 14, n. 9, 2022. Disponível em: https://doi.org/10.3390/polym14091806.
DHAKAL, R. et al. Development and application of MAGIC-F gel in radiation dosimetry. Applied Sciences, v. 11, n. 17, 7783, 2021. Disponível em: https://doi.org/10.3390/app11177783.
DOYAN, A.; SUSILAWATI; ANNAM, S. Trend research of polymer gel dosimetry: A systematic review. Journal of Material Science and Radiation, 2025. Disponível em: https://journals.balaipublikasi.id/index.php/jmsr/article/view/362.
FERNANDES, J. P. et al. Formaldehyde increases MAGIC gel dosimeter melting point and sensitivity. Journal of Physics: Conference Series, v. 164, 012004, 2009. Disponível em: https://doi.org/10.1088/1742-6596/164/1/012004.
FONG, P. M. et al. Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere. Physics in Medicine & Biology, v. 46, n. 12, p. 3105–3113, 2001. Disponível em: https://doi.org/10.1088/0031-9155/46/12/311.
HAMANN, J. H.; BALDOCK, C. Polymerization mechanisms of polymer gel dosimeters induced by ionizing radiation. Radiation Physics and Chemistry, v. 188, 109610, 2021. Disponível em: https://doi.org/10.1016/j.radphyschem.2021.109610.
JAWLI, A. et al. Tissue-mimicking material fabrication and properties for multiparametric ultrasound phantoms: A systematic review. Bioengineering, v. 11, n. 6, 620, 2024. Disponível em: https://doi.org/10.3390/bioengineering11060620.
JIRÁSEK, A. et al. Radiation-induced polymerization in gel dosimeters. Radiation Physics and Chemistry, v. 196, 110188, 2022. Disponível em: https://doi.org/10.1016/j.radphyschem.2022.110188.
KIM, H. M. et al. Experimental study on properties of ultrasonic coupling and acoustic impedance of polymer hydrogels. Applied Sciences, v. 12, n. 3, 1236, 2022. Disponível em: https://doi.org/10.3390/app12031236.
LANDAU, L. D.; LIFSHITZ, E. M. Theory of elasticity. 3. ed. Oxford: Pergamon Press, 1986.
LIU, Z. et al. Layer-specific shear wave elastography using a multi-layered shear wave dispersion model for assessing viscoelastic properties. Physics in Medicine & Biology, v. 66, n. 3, 035003, 2021. Disponível em: https://doi.org/10.1088/1361-6560/abd7b2.
LUBBERS, J.; FLETCHER, C. A. J. A simple and accurate formula for the sound velocity in water. Ultrasonics, v. 36, p. 79–82, 1998. Disponível em: https://doi.org/10.1016/S0041-624X(97)00068-3.
MASOUMI, H.; MOKHTARI-DIZAJI, M.; ARBABI, A.; BAKHSHANDEH, M. Determine the dose distribution using ultrasound parameters in MAGIC-F polymer gels. Dose-Response, v. 14, n. 1, p. 1559325815625647, 2016. Disponível em: https://doi.org/10.1177/1559325815625647.
MATHER, M. L. et al. Investigation of ultrasonic properties of PAG and MAGIC polymer gel dosimeters. Physics in Medicine & Biology, v. 47, n. 24, p. 4397–4409, 2002. Disponível em: https://doi.org/10.1088/0031-9155/47/24/304.
MCHUGH, J. Ultrasound technique for the dynamic mechanical analysis (DMA). Berlin: Bundesanstalt für Materialforschung und -prüfung, 2008.
NEIDHARDT, M. Parameter identification for ultrasound shear wave imaging with gelatin phantoms. Hamburg: Hamburg University of Technology, 2021. Disponível em: https://tubdok.tub.tuhh.de/handle/11420/11263.
ONO, K. Ultrasonic attenuation of carbon-fiber reinforced composites. Journal of Composites Science, v. 7, n. 11, 479, 2023. Disponível em: https://doi.org/10.3390/jcs7110479.
ROYER, D.; DIEULESAINT, E. Elastic waves in solids I: free and guided propagation. Berlin: Springer, 2000.
SAGSOZ, M. E. Advancements in tissue-equivalent gel dosimeters. Gels, 2025. Disponível em: https://www.iris.unict.it/bitstream/20.500.11769/657729/1/Gels_Erdem_2025.pdf.
SALMAN, M. D. et al. A novel 3D polymer gel dosimeter based on polymethyl methacrylate gel (PMMAG) for radiotherapy: Ultrasonic evaluation. Radiation Physics and Chemistry, v. 226, 112286, 2025. Disponível em: https://doi.org/10.1016/j.radphyschem.2024.112286.
TABERLET, N. et al. How tall can gelatin towers be? An introduction to elasticity and buckling. American Journal of Physics, v. 85, n. 12, p. 908–914, 2017. Disponível em: https://doi.org/10.1119/1.5003804.
VIEIRA, S. L. Desenvolvimento de um phantom para treinamento de biópsia de mama guiada por ultrassom. 2005. Dissertação (Mestrado em Física) – Universidade de São Paulo, Ribeirão Preto, 2005. Disponível em: https://teses.usp.br/teses/disponiveis/59/59135/tde-06042006-161902.
VIEIRA, S. L. Imagens das propriedades viscoelásticas por ressonância magnética e ultrassom. 2009. Tese (Doutorado em Física) – Universidade de São Paulo, Ribeirão Preto, 2009. Disponível em: https://teses.usp.br/teses/disponiveis/59/59135/tde-22092009-161413.
VIEIRA, S. L. et al. Paraffin-gel tissue-mimicking material for ultrasound-guided needle biopsy phantom. Ultrasound in Medicine & Biology, v. 39, n. 12, p. 2477–2484, 2013. Disponível em: https://doi.org/10.1016/j.ultrasmedbio.2013.06.004.
VIEIRA, S. L. et al. Quantitative magnetic resonance elastography for polymer-gel dosimetry phantoms. Medical Engineering & Physics, v. 66, p. 102–106, 2019. Disponível em: https://doi.org/10.1016/j.medengphy.2019.02.005.
ZHANG, X. et al. Ultrasound elastography: principles and clinical applications. Theranostics, v. 7, n. 5, p. 1303–1329, 2017. Disponível em: https://doi.org/10.7150/thno.18650.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Ana Clara Oliveira de Queiroz Teófilo, Pedro Henrique Dias Coelho, Sílvio Leão Vieira

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
Authors retain copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which permits the sharing of the work with proper acknowledgment of authorship and initial publication in this journal;
Authors are authorized to enter into separate, additional agreements for the non-exclusive distribution of the version of the work published in this journal (e.g., posting in an institutional repository or publishing it as a book chapter), provided that authorship and initial publication in this journal are properly acknowledged, and that the work is adapted to the template of the respective repository;
Authors are permitted and encouraged to post and distribute their work online (e.g., in institutional repositories or on their personal websites) at any point before or during the editorial process, as this may lead to productive exchanges and increase the impact and citation of the published work (see The Effect of Open Access);
Authors are responsible for correctly providing their personal information, including name, keywords, abstracts, and other relevant data, thereby defining how they wish to be cited. The journal’s editorial board is not responsible for any errors or inconsistencies in these records.
PRIVACY POLICY
The names and email addresses provided to this journal will be used exclusively for the purposes of this publication and will not be made available for any other purpose or to third parties.
Note: All content of the work is the sole responsibility of the author and the advisor.
