EVALUATION OF FEMALE SEX HORMONES ON PERIODONTAL TISSUES OF OBESE RATS SUBJECTED TO EXPERIMENTAL PERIODONTITIS
DOI:
https://doi.org/10.66104/1epwtw35Keywords:
Obesity; Periodontal disease; Bone tissue.Abstract
Objective: The aim of this study was to evaluate the effect of hormonal influence on the periodontal tissues of adult rats in the proestrus phase of the estrous cycle, with experimentally induced obesity through a cafeteria diet, associated or not with periodontal disease. Design: For this study, 20 adult cycling female rats in the proestrus phase of the estrous cycle were divided into a control group (CON), a ligature group (LIG), a cafeteria group (CAF), and a cafeteria and ligature group (CAFLIG). At 75 days of age, the animals in the LIG and CAFLIG groups received a ligature around the first right lower molar, which acted as a gingival irritant for 30 days, favoring the accumulation of bacterial plaque and consequent development of periodontal disease. After euthanasia, at 105 days of age, blood was collected from the right brainstem to determine estradiol and progesterone concentrations using specific kits; and the dissection of the right hemi-mandible, which was submitted to histological analysis. The data obtained were analyzed and evaluated using ANOVA and Tukey tests. Results: The results demonstrate a decrease in the concentration of female sex hormones when obesity and periodontal disease were associated; similarly, marked bone resorption and changes in bone tissue morphology were observed in the CAF/LIG group. Conclusion: Based on the results obtained, this study can conclude that the decrease in female sex hormones associated with obesity and periodontal disease negatively interfered with mandibular bone tissue.
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Copyright (c) 2026 Poliana de Fátima Biederman, Alana Zenilda Thomaz Sacht, Vitoria Bortolon Jassniker, Mateus Pacer de Lima, Carlos Augusto Nassar, Rose Meire Costa, Sara Cristina Sagae, Patricia Oehlmeyer Nassar
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