BENEFITS OF RESISTANT STARCH ON THE INTESTINAL MICROBIOTA
DOI:
https://doi.org/10.66104/pabx2s44Keywords:
Gut microbiota; Resistant starch; Short-chain fatty acids; Plant-based.Abstract
The gut microbiota plays an essential role in metabolic, immunological, and gastrointestinal health and is strongly influenced by diet and the intake of fermentable fibers. Among these, resistant starch (RS) stands out as a fraction of starch that escapes digestion in the small intestine and is fermented in the colon, producing short-chain fatty acids with both systemic and intestinal effects. Thus, this study aimed to analyze, through an integrative review, the benefits of RS, especially subtypes RS-2 and RS-3, on the modulation of the gut microbiota and its clinical outcomes. This is an integrative review of clinical trials published between 2020 and 2025, in Portuguese and English, from the PubMed, ScienceDirect, and LILACS databases. A total of 12 studies investigating the effects of RS on metabolic and microbiological parameters were included. This body of evidence enabled a comprehensive and comparative analysis of the main clinical outcomes associated with RS consumption. The results show that RS-2 has consistent effects in improving insulin sensitivity, reducing hepatic lipids, modulating uremic toxins, and increasing butyrate-producing bacteria. In contrast, RS-3 demonstrated more specific benefits related to intestinal barrier integrity, including reduced epithelial permeability, improved intestinal transit, and attenuation of the glycemic response resulting from the retrogradation process. These findings indicate that RS exerts beneficial and complementary effects on the gut microbiota and metabolic parameters, with RS-2 showing broader impacts on systemic markers and RS-3 demonstrating a more targeted role in intestinal integrity and glycemic control. Therefore, RS emerges as a promising nutritional tool for intestinal support and metabolic modulation. However, further studies are needed to define optimal doses, potential prebiotic synergies, and individual response profiles to optimize its clinical application.
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Copyright (c) 2026 Ana Luísa Pires Tavares , Beatriz Jeovana da Silva Rodrigues, Rikelme da Silva Rocha , Francielle Castelo Branco Silva, João Pedro Sousa de Sá, Marilene Magalhães de Brito, Luana Mota Martins
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