EVALUACIÓN DE LA ASOCIACIÓN DEL ACEITE ESENCIAL DE LAVANDULA HYBRIDA GROSSO CON ANTIMICROBIANOS SINTÉTICOS CONTRA KREBSIELLA PNEUMONIAE
DOI:
https://doi.org/10.61164/rmnm.v11i1.1618Palabras clave:
Fitoterapia, Microbiología, Odontología.Resumen
Klebsiella pneumoniae es un patógeno de difícil manejo, y sus cepas pueden presentar diversos niveles de resistencia a los antimicrobianos utilizados para su tratamiento, como penicilinas, antimicrobianos, carbapenems, entre otros. Por lo tanto, la capacidad terapéutica es limitada, y es de suma importancia estudiar y dilucidar los mecanismos patogénicos y de resistencia asociados a K. pneumoniae, para que pueda haber una mejor intervención terapéutica. De este modo, el uso de productos naturales de origen vegetal es una opción terapéutica a tener en cuenta. El objetivo de este estudio fue evaluar la asociación del aceite esencial de Lavandula hybrida grosso con antimicrobianos sintéticos frente a Krebsiella pneumoniae. La prueba de asociación se realizó mediante la técnica de difusión utilizando cepas de Klebsiella pneumoniae (KP 101, KP 102, KP 103 y KP 104) del Laboratorio de Microbiología de la Unidad Académica de Ciencias Biológicas del Centro de Salud y Tecnología Rural de la Universidad Federal de Campina Grande. A continuación, se combinó el aceite esencial de Lavandula Hybridis Grosso, adquirido en Quinare, con los antimicrobianos ampicilina y gentamicina (10 μg/mL). Para la mayoría de las cepas analizadas y de los antimicrobianos utilizados, el aceite esencial tuvo un efecto sinérgico. Así pues, se puede observar que la asociación del aceite esencial de Lavándula con antimicrobianos sintéticos puede ser una opción a utilizar en farmacología, pero se necesitan más estudios para confirmar esta hipótesis.
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