O USO DO CANABIDIOL NO TRATAMENTO DA ACNE
DOI:
https://doi.org/10.61164/rmnm.v11i1.4019Palabras clave:
Canabidiol, Cannabis sativa, acne, cosmético, pele, anti-inflamatório.Resumen
A acne é uma doença que afeta grande parte da população, e seu tratamento requer estratégias diferenciadas. Atualmente, a busca por alternativas naturais de tratamento tópicos tem crescido no mundo todo. A planta Cannabis sativa ficou conhecida por ser utilizada para obter as sensações de excitação e relaxamento que as substâncias provenientes de suas flores são capazes de proporcionar. Uma delas é o Canabidiol, um composto não psicoativo que possui diversas propriedades terapêuticas. Este estudo consistiu em uma revisão da literatura sobre os efeitos terapêuticos da Cannabis sativa, especialmente do canabidiol (CBD), para o tratamento da acne. A pesquisa foi realizada utilizando artigos, teses e dissertações nas bases de dados, do Scopus, do PUBMED e do Google Acadêmico. Estudos apontam que o Canabidiol possui atividade anti-inflamatória na pele e tem potencial para ser manipulado em forma de cosmético de uso tópico para prevenir e combater a acne causada por bactéria, sem ocasionar danos ao paciente. Apesar de sua atividade terapêutica ter sido constatada, mais estudos em relação ao ativo precisam acontecer. Enquanto isso, o seu uso segue sendo apenas uma esperança para futuros tratamentos alternativos da acne, tendo em vista que a substância faz parte de uma planta que ainda é criminalizada.
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Referencias
ALMEIDA, B.L. Modelo de pele humana reconstruída como plataforma para estudos de fotoenvelhecimento. 2020. Acesso em 17 de Fevereiro de 2025.
Aizpurua-Olaizola, O., Soydaner, U., Öztürk, E., Schibano, D., Simsir, Y., Navarro, P., Etxebarria, N., & Usobiaga, A. (2016). Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes. Journal of Natural Products, 79(2), 324–331. https://doi.org/10.1021/acs.jnatprod.5b00949
Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and anti-inflammatory properties of cannabidiol. Antioxidants (Basel, Switzerland), 9(1), 21.
Baswan, S. M., Klosner, A. E., Glynn, K., Rajgopal, A., Malik, K., Yim, S., & Stern, N. (2020). Therapeutic potential of cannabidiol (CBD) for skin health and disorders. Clinical, Cosmetic and Investigational Dermatology, 13, 927–942
Bollag, W. B., Aitkens, L., White, J., & Hyndman, K. A. (2020). Aquaporin-3 in the epidermis: more than skin deep. American Journal of Physiology. Cell Physiology, 318(6), C1144–C1153
Carliner, H., Brown, Q. L., Sarvet, A. L., & Hasin, D. S. (2017). Cannabis use, attitudes, and legal status in the U.S.: A review. Preventive medicine, 104, 13– 23. https://doi.org/10.1016/j.ypmed.2017.07.008
Casares, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L., & Muñoz, E. (2020). Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biology, 28(101321), 101321.
Casiraghi, A., Musazzi, U. M., Centin, G., Franzè, S., & Minghetti, P. (2020). Topical administration of cannabidiol: Influence of vehicle-related aspects on skin permeation process. Pharmaceuticals (Basel, Switzerland), 13(11), 337.
Castillo, D. E., Nanda, S., & Keri, J. E. (2019). Propionibacterium (Cutibacterium) acnes bacteriophage therapy in acne: Current evidence and future perspectives. Dermatology and Therapy, 9(1), 19–31.
CLARISSA, et al. Revisão literária sobre as evidências do canabidiol para o tratamento de acne. 2023. Acesso em 17 de Fevereiro de 2025.
Fox, L., Csongradi, C., Aucamp, M., du Plessis, J., & Gerber, M. (2016). Treatment modalities for acne. Molecules (Basel, Switzerland), 21(8), 1063.
GOMES, L. P. et al. Influência dos cuidados com a pele no controle da acne em adolescentes. Revista eletrônica interdisciplinar, v.12, n.2, p. 013-022, 2020.
Graczyk, M., Lewandowska, A. A., & Dzierżanowski, T. (2021). The therapeutic potential of cannabis in counteracting oxidative stress and inflammation. Molecules (Basel, Switzerland), 26(15), 4551.
Gravitz L. Skin. Nature. 2018 Nov;563(7732):S83. 10.1038/d41586-018-07428-4
Hargis, A. M., & Myers, S. (2017). The Integument. In Pathologic Basis of Veterinary Disease (pp. 1009-1146.e1). Elsevier.
Hashim, P. W., Cohen, J. L., Pompei, D. T., & Goldenberg, G. (2017). Topical cannabinoids in dermatology. Cutis; Cutaneous Medicine for the Practitioner, 100(1), 50–52.
Hoover, E., Aslam, S., & Krishnamurthy, K. (2020). Physiology, Sebaceous Glands. In StatPearls. StatPearls Publishing
Iffland, K., & Grotenhermen, F. (2017). An update on safety and side effects of cannabidiol: A review of clinical data and relevant animal studies. Cannabis and Cannabinoid Research, 2(1), 139–154.
Isidore, E., Karim, H., & Ioannou, I. (2021). Extraction of phenolic compounds and terpenes from cannabis sativa L. by-products: From conventional to intensified processes. Antioxidants (Basel, Switzerland), 10(6), 942.
KUPAI, K. et al. Matrix metalloproteinase activity assays: Importance of zymography. Journal of Pharmacological and Toxicological Methods, v. 61, n. 2, p. 205–209, 2010. LAICHEONG, J. E.; MCGRATH, J. A. Structure and function of skin, hair and nails.
LETICIA, et al. Efeito do óleo de Canabidiol (CBD) sobre a acne. 2021. Acesso em 17 de Fevereiro de 2025.
Lewis, M. M., Yang, Y., Wasilewski, E., Clarke, H. A., & Kotra, L. P. (2017). Chemical Profiling of Medical Cannabis Extracts. ACS Omega, 2(9), 6091–6103. https://doi.org/10.1021/acsomega.7b00996
OLÁH, A. et al. Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental dermatology, v. 25, n. 9, p. 701707, 2016.
Osseiran, S., Cruz, J. D., Jeong, S., Wang, H., Fthenakis, C., & Evans, C. L. (2018). Characterizing stratum corneum structure, barrier function, and chemical content of human skin with coherent Raman scattering imaging. Biomedical Optics Express, 9(12), 6425–6443
Rippa, A. L., Kalabusheva, E. P., & Vorotelyak, E. A. (2019). Regeneration of dermis: Scarring and cells involved. Cells (Basel, Switzerland), 8(6), 607.
Souza, A. A. F. de, Silva, A. F. M. da, Abreu, L. R. de, Silva, T. F. da, Greco, G., Santos, S. da S., & Gonzaga, R. V. (2021). Medicinal uses of Cannabis sp. Research, Society and Development, 10(7), e58010716930.
Veniaminova, N. A., Grachtchouk, M., Doane, O. J., Peterson, J. K., Quigley, D. A., Lull, M. V., Pyrozhenko, D. V., Nair, R. R., Patrick, M. T., Balmain, A., Dlugosz, A. A., Tsoi, L. C., & Wong, S. Y. (2019). Niche-specific factors dynamically regulate sebaceous gland stem cells in the skin. Developmental Cell, 51(3), 326-340.e4.
Yousef, H., Alhajj, M., & Sharma, S. (2021). Anatomy, skin (integument), epidermis. In StatPearls. StatPearls Publishing.
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