O MANEJO FARMACÊUTICO NA DOENÇA DE PARKINSON: ESTRATÉGIAS DE SUPLEMENTAÇÃO PARA OTIMIZAÇÃO TERAPÊUTICA
DOI:
https://doi.org/10.66104/6m5xxx41Palabras clave:
Cuidados Farmacêuticos, Doença de Parkinson, Suplementos NutricionaisResumen
A Doença de Parkinson (DP) é uma condição neurodegenerativa associada ao estresse oxidativo e à disfunção mitocondrial, o que torna promissora a suplementação com compostos antioxidantes como estratégia adjuvante. Este trabalho objetivou avaliar as evidências sobre a eficácia e segurança da suplementação com ômega-3, coenzima Q10 (CoQ10) e N-acetilcisteína (NAC) na DP, além de discutir o papel do farmacêutico clínico nesse contexto. Trata-se de uma revisão integrativa da literatura, com busca nas bases BVS, PubMed e SciELO, utilizando descritores relacionados à DP e aos suplementos de interesse. Foram selecionados 10 artigos publicados entre 2015 e 2025. Os resultados indicam que o ômega-3, especialmente associado à vitamina E, apresentou resultados consistentes no retardo da progressão da doença, sintomas depressivos e marcadores inflamatórios. Já a CoQ10, apesar do potencial neuroprotetor em modelos pré-clínicos, não demonstrou eficácia significativa por via oral, provavelmente, em decorrência da baixa biodisponibilidade. A NAC demonstrou resultados promissores em estudos pré-clínicos e clínicos iniciais, com melhora em biomarcadores dopaminérgicos e função motora, embora estudos apontem riscos de efeitos adversos em doses elevadas. Conclui-se que o ômega-3 apresenta evidências mais consolidadas como adjuvante na DP, enquanto CoQ10 e NAC necessitam de mais estudos de investigação a respeito da sua atividade. O farmacêutico clínico exerce papel essencial na avaliação crítica da literatura, individualização da conduta e monitoramento da segurança e eficácia da suplementação.
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Derechos de autor 2026 Ana Catarina Simonetti Monteiro, Carolayne da Silva Laurentino, Juliana Josefa da Silva, Maria Gleice Silva Monteiro, Gleiciane Adrielli Souza Guinho, João Paulo de Melo Guedes, Clayton Anderson de Azevedo Filho , Risonildo Pereira Cordeiro
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