Microagujamiento Asociado con Polidesoxirribonucleótido en las Disfunciones Estéticas: Revisión Narrativa
DOI:
https://doi.org/10.66104/ryvhdg20Palabras clave:
Microagujamiento. Polidesoxirribonucleótido. Disfunciones estéticas. Rejuvenecimiento cutáneo.Resumen
El envejecimiento cutáneo, determinado por la convergencia de factores intrínsecos y extrínsecos, promueve alteraciones estructurales progresivas en la dermis, destacándose la fragmentación de las fibras colágenas, la reducción de la hidratación tisular y la aparición de discromías. Ante este escenario, los procedimientos mínimamente invasivos con potencial regenerativo han ganado un espacio creciente en la biomedicina estética, entre los cuales destacan el microagujamiento, técnica de inducción percutánea de colágeno por agujas (IPCA), y el polidesoxirribonucleótido (PDRN), biopolímero de origen salmonídeo con comprobada actividad bioestimuladora a través del receptor de adenosina A2A.
El presente estudio tuvo como objetivo analizar las evidencias científicas disponibles sobre la asociación entre estos dos abordajes en las disfunciones estéticas, caracterizando sus mecanismos de acción y verificando los desenlaces clínicos reportados en los dominios de neocolagénesis, hidratación cutánea, uniformización de la textura y reducción de discromías. Se trata de una revisión narrativa de la literatura, con búsqueda no sistemática realizada en las bases de datos PubMed/MEDLINE, SciELO, LILACS, Scopus y Google Scholar, organizando los hallazgos en torno a tres áreas temáticas correspondientes a los objetivos específicos.
Los resultados evidenciaron que la asociación entre microagujamiento y PDRN produce desenlaces clínicos superiores a los obtenidos con el uso aislado de cada técnica, sustentados por una sinergia biológicamente fundamentada en la potenciación transdérmica del PDRN a través de los microcanales creados por el microagujamiento. Se concluye que la terapia combinada representa una estrategia prometedora y clínicamente relevante, aunque son necesarios estudios con mayor rigor metodológico para la consolidación de protocolos estandarizados.
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