NANOPARTICLE-BASED CONTROLLED RELEASE SYSTEM FOR CHEMOTHERAPEUTICS: INTEGRATIVE REVIEW
DOI:
https://doi.org/10.61164/m8xd2x31Keywords:
Systems; nanoparticles; chemotherapeutics; controlled releaseAbstract
Cancer is one of the leading causes of death in the Americas and is expected to reach 6.7 million cases by 2045. Factors such as smoking, alcohol consumption, and lifestyle habits contribute to its development. Conventional therapies face several limitations, including low efficacy and high toxicity. Nanotechnology emerges as a promising solution, employing nanoparticles that allow controlled and targeted release of chemotherapeutic agents, thereby reducing side effects. These systems improve pharmacokinetics, protect drugs, and facilitate cellular uptake. Functionalization with specific ligands enhances precision in targeting tumors. Thus, nanotechnology offers more effective and personalized treatments against cancer. This study aims, through an integrative literature review, to examine the effectiveness of nanoparticle-based controlled release systems for chemotherapeutic agents. The present research consists of an integrative review of scientific literature. Data collection was carried out in scientific databases such as the Virtual Health Library (BVS), PubMed (including its platforms), Scientific Electronic Library Online (SciELO), and the National Center for Biotechnology Information (NCBI). Inclusion criteria considered studies published between 2019 and 2025, available in full text in Portuguese, English, or Spanish, and whose objectives were aligned with the research theme. This work seeks to present essential information to guide healthcare professionals and patients regarding the advantages and limitations of controlled release systems for chemotherapeutic drugs, enabling a critical and well-founded evaluation of this therapeutic approach in cancer treatment. The results show that these technologies, based on nanoparticles and liposomes, allow for greater tumor targeting, sustained release, and reduction of adverse effects, increasing the effectiveness and adherence to treatment. It is concluded that these systems represent an important advance in cancer therapy, although they still face challenges regarding standardization and production costs.
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