NANOPARTICLE-BASED CONTROLLED RELEASE SYSTEM FOR CHEMOTHERAPEUTICS: INTEGRATIVE REVIEW
DOI:
https://doi.org/10.61164/m8xd2x31Keywords:
Systems; nanoparticles; chemotherapeutics; controlled releaseAbstract
Cancer is one of the leading causes of death in the Americas and is expected to reach 6.7 million cases by 2045. Factors such as smoking, alcohol consumption, and lifestyle habits contribute to its development. Conventional therapies face several limitations, including low efficacy and high toxicity. Nanotechnology emerges as a promising solution, employing nanoparticles that allow controlled and targeted release of chemotherapeutic agents, thereby reducing side effects. These systems improve pharmacokinetics, protect drugs, and facilitate cellular uptake. Functionalization with specific ligands enhances precision in targeting tumors. Thus, nanotechnology offers more effective and personalized treatments against cancer. This study aims, through an integrative literature review, to examine the effectiveness of nanoparticle-based controlled release systems for chemotherapeutic agents. The present research consists of an integrative review of scientific literature. Data collection was carried out in scientific databases such as the Virtual Health Library (BVS), PubMed (including its platforms), Scientific Electronic Library Online (SciELO), and the National Center for Biotechnology Information (NCBI). Inclusion criteria considered studies published between 2019 and 2025, available in full text in Portuguese, English, or Spanish, and whose objectives were aligned with the research theme. This work seeks to present essential information to guide healthcare professionals and patients regarding the advantages and limitations of controlled release systems for chemotherapeutic drugs, enabling a critical and well-founded evaluation of this therapeutic approach in cancer treatment. The results show that these technologies, based on nanoparticles and liposomes, allow for greater tumor targeting, sustained release, and reduction of adverse effects, increasing the effectiveness and adherence to treatment. It is concluded that these systems represent an important advance in cancer therapy, although they still face challenges regarding standardization and production costs.
Downloads
References
ADEPU, S.; RAMAKRISHNA, S. Controlled drug delivery systems: current status and future directions. Molecules, v. 26, n. 19, p. 5905, 2021. DOI: https://doi.org/10.3390/molecules26195905
BAETKE, S. C.; LAMMERS, T.; KIESSLING, F. Applications of nanoparticles for diagnosis and therapy of cancer. British Journal of Radiology, v. 88, n. 1054, 2015. DOI: 10.1259/bjr.20150207. DOI: https://doi.org/10.1259/bjr.20150207
BRASIL. Ministério da Saúde. ABC do câncer: abordagens básicas para o controle do câncer. 2. ed. Brasília: Ministério da Saúde, 2012. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/abc_do_cancer.pdf. Acesso em: 18 mar. 2025.
BRASIL. Ministério da Saúde. Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). Estatísticas de câncer – dados de mortalidade em 2021. Rio de Janeiro: INCA, 2022. Disponível em: https://www.gov.br/inca/pt-br/assuntos/cancer/numeros. Acesso em: 14 out. 2025.
CHEN, J. et al. Recent advances and clinical translation of liposomal delivery systems in cancer therapy. European Journal of Pharmaceutical Sciences, v. 193, p. 106688, 2024. DOI: 10.1016/j.ejps.2023.106688. DOI: https://doi.org/10.1016/j.ejps.2023.106688
DANG, Y.; GUAN, J. Nanoparticle-based drug delivery systems for cancer therapy. Smart Materials in Medicine, v. 1, p. 10–19, 2020. DOI: 10.1016/j.smaim.2020.04.001. DOI: https://doi.org/10.1016/j.smaim.2020.04.001
FEREIDOUNI, F. et al. Advances in the systemic administration of nanotechnology-mediated drug delivery systems in melanoma treatment: a systematic review. Discover Applied Sciences, v. 7, n. 512, p. 1–25, 2025. DOI: 10.1007/s42452-025-06998-z. DOI: https://doi.org/10.1007/s42452-025-06998-z
HASAN, M.; EVETT, C. G.; BURTON, J. Advances in nanoparticle-based targeted drug delivery systems for colorectal cancer therapy: a review. Department of Chemistry, University of South Dakota, Vermillion, 2025.
INSTITUTO NACIONAL DE CÂNCER JOSÉ ALENCAR GOMES DA SILVA (INCA). Estimativa 2023: incidência de câncer no Brasil. Rio de Janeiro: INCA, 2022. Disponível em: https://www.gov.br/inca/pt-br/assuntos/cancer/numeros. Acesso em: 14 out. 2025.
LARRAÑETA, E.; DOMÍNGUEZ-ROBLES, J. Long-acting drug delivery systems: current landscape and future prospects. Drug Discovery Today, v. 30, n. 9, p. 104447, 2025. DOI: https://doi.org/10.1016/j.drudis.2025.104447
LEWANDOWSKA, A. M. et al. Environmental risk factors for cancer – review paper. Annals of Agricultural and Environmental Medicine, v. 26, n. 1, p. 1–7, 2019. DOI: 10.26444/aaem/94299. DOI: https://doi.org/10.26444/aaem/94299
MANAIA, E. B. et al. Physicochemical characterization of drug nanocarriers. International Journal of Nanomedicine, v. 12, p. 4991–5011, 2017. DOI: 10.2147/IJN.S133832. DOI: https://doi.org/10.2147/IJN.S133832
NAMMAS, M. The impact of drug delivery systems on pharmacokinetics and drug-drug interactions in neuropsychiatric treatment. Cureus, v. 17, n. 6, e85563, 2025. DOI: 10.7759/cureus.85563. DOI: https://doi.org/10.7759/cureus.85563
NASIR, A. et al. Nanotechnology: a tool for diagnostics and treatment of cancer. Current Topics in Medicinal Chemistry, v. 21, n. 15, p. 1360–1376, 2021. DOI: 10.2174/1568026621666210701144124. DOI: https://doi.org/10.2174/1568026621666210701144124
NATIONAL CANCER INSTITUTE (NCI). Cancer Nanotechnology: Current Treatments. National Cancer Institute, 2022. Disponível em: https://www.cancer.gov/nano/cancer-nanotechnology/current-treatments. Acesso em: 20 mar. 2025.
ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE (OPAS). Câncer. OPAS/OMS, 2023. Disponível em: https://www.paho.org/pt/topicos/cancer. Acesso em: 20 mar. 2025.
PATRA, J. K. et al. Nano based drug delivery systems: recent developments and future prospects. Journal of Nanobiotechnology, v. 16, n. 71, 2018. DOI: 10.1186/s12951-018-0392-8. DOI: https://doi.org/10.1186/s12951-018-0392-8
PRABHU, R. H.; PATRAVALE, V. B.; JOSHI, M. D. Polymeric nanoparticles for targeted treatment in oncology: current insights. International Journal of Nanomedicine, v. 10, p. 1001–1018, 2015. DOI: 10.2147/IJN.S56932. DOI: https://doi.org/10.2147/IJN.S56932
SABIN. Tipos mais comuns de câncer. Blog Sabin, [s.d.]. Disponível em: https://blog.sabin.com.br/saude/tipos-mais-comuns-de-cancer/. Acesso em: 15 out. 2025.
SCHERÜBL, H. Tabakrauchen und Krebsrisiko. Deutsche Medizinische Wochenschrift, v. 146, n. 6, p. 412–417, 2021. DOI: 10.1055/a-1216-7050. DOI: https://doi.org/10.1055/a-1216-7050
SILVA, G. A. et al. Mortalidade por câncer nas capitais e no interior do Brasil: uma análise de quatro décadas. Revista de Saúde Pública, v. 54, p. 126, 2020. DOI: https://doi.org/10.11606/s1518-8787.2020054002255
SOARES, T. do N. et al. Aplicação de nanocarreadores como estratégia na terapia do câncer de pele. Brazilian Journal of Development, v. 8, n. 9, p. 63560–63575, 2022. DOI: 10.34117/bjdv8n9-210. DOI: https://doi.org/10.34117/bjdv8n9-210
SOUZA, M. T.; SILVA, M. D.; CARVALHO, R. Revisão integrativa: o que é e como fazer. Einstein (São Paulo), v. 8, p. 102–106, 2010. DOI: https://doi.org/10.1590/s1679-45082010rw1134
SUN, R. et al. The drug release of PLGA-based nanoparticles and their application in treatment of gastrointestinal cancers. Heliyon, v. 10, n. 18, e38165, 2024. DOI: 10.1016/j.heliyon.2024.e38165. DOI: https://doi.org/10.1016/j.heliyon.2024.e38165
SUN, L.; LIU, H.; YE, Y. et al. Smart nanoparticles for cancer therapy. Signal Transduction and Targeted Therapy, v. 8, p. 418, 2023. DOI: 10.1038/s41392-023-01642-x. DOI: https://doi.org/10.1038/s41392-023-01642-x
YAO, L. et al. Application of nanotechnology in TACE treatment of liver cancer. International Journal of Nanomedicine, v. 20, p. 9621–9639, 2025. DOI: https://doi.org/10.2147/IJN.S527518
YUSUF, A. et al. Nanoparticles as drug delivery systems: a review of the implication of nanoparticles’ physicochemical properties on responses in biological systems. Polymers, v. 15, n. 1596, 2023. DOI: 10.3390/polym15071596. DOI: https://doi.org/10.3390/polym15071596
ZAIMY, M. A. et al. New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles. Cancer Gene Therapy, v. 24, n. 6, p. 233–243, 2017. DOI: 10.1038/cgt.2017.16. DOI: https://doi.org/10.1038/cgt.2017.16
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Ryann Rodrigues Cardoso, José Guilherme Ferreira Marques Galvão, Ana Emília Formiga Marques, Diego Igor Alves Fernandes de Araújo
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
Authors retain copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License, which permits the sharing of the work with proper acknowledgment of authorship and initial publication in this journal;
Authors are authorized to enter into separate, additional agreements for the non-exclusive distribution of the version of the work published in this journal (e.g., posting in an institutional repository or publishing it as a book chapter), provided that authorship and initial publication in this journal are properly acknowledged, and that the work is adapted to the template of the respective repository;
Authors are permitted and encouraged to post and distribute their work online (e.g., in institutional repositories or on their personal websites) at any point before or during the editorial process, as this may lead to productive exchanges and increase the impact and citation of the published work (see The Effect of Open Access);
Authors are responsible for correctly providing their personal information, including name, keywords, abstracts, and other relevant data, thereby defining how they wish to be cited. The journal’s editorial board is not responsible for any errors or inconsistencies in these records.
PRIVACY POLICY
The names and email addresses provided to this journal will be used exclusively for the purposes of this publication and will not be made available for any other purpose or to third parties.
Note: All content of the work is the sole responsibility of the author and the advisor.
