Nanotechnology Applied to Pharmaceutical Chemistry
DOI:
https://doi.org/10.61164/hv1ceb36Keywords:
Nanotechnology; Pharmaceutical Chemistry; Nanoparticles; Innovation.Abstract
Nanotechnology is a rapidly expanding science that has profoundly changed the course of the pharmaceutical and medicinal chemistry industries. By operating at the nanoscale, it is possible to control the physicochemical properties of materials, favoring the bioavailability, selectivity, and efficacy of drugs. This article aims to discuss the main applications of nanotechnology in pharmaceutical chemistry, addressing controlled-release systems, advanced diagnostics, and new pharmacological formulations. The research was conducted through a literature review in national and international scientific databases. It was found that nanotechnology provides significant gains in cancer treatments, infectious diseases, and vaccines, but still faces challenges regarding toxicity, stability, and regulation. Furthermore, it is observed that the development of nanosystems opens avenues for personalized medicine, allowing for safer, more effective, and innovative therapies capable of profoundly transforming the future of pharmacotherapy.
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ALLEN, T. M.; CULLIS, P. R. Liposomal drug delivery systems: From concept to clinical applications. Advanced Drug Delivery Reviews, v. 65, n. 1, p. 36-48, 2013. DOI: https://doi.org/10.1016/j.addr.2012.09.037
ANVISA. Relatório de Nanotecnologia e Regulação no Brasil. Brasília: ANVISA, 2022.
BHUSHAN, B. Springer Handbook of Nanotechnology. 4. ed. Berlin: Springer, 2017. DOI: https://doi.org/10.1007/978-3-662-54357-3
FERRARI, M. Cancer nanotechnology: Opportunities and challenges. Nature Reviews Cancer, v. 5, n. 3, p. 161-171, 2005. DOI: https://doi.org/10.1038/nrc1566
FERREIRA, L. S. et al. Nanotecnologia e indústria farmacêutica: tendências e perspectivas. Revista Brasileira de Ciências Farmacêuticas, v. 57, n. 2, p. 88-96, 2021.
FONSECA, C. et al. Polymeric nanoparticles for drug delivery: Current developments and future directions. Journal of Biomedical Nanotechnology, v. 14, n. 1, p. 1-19, 2018.
JIANG, W. et al. Nanoparticle-mediated cellular responses: Implications for cancer therapy. Nano Today, v. 35, p. 100937, 2020. DOI: https://doi.org/10.1016/j.nantod.2020.100946
KRAMMER, F. SARS-CoV-2 vaccines in development. Nature, v. 586, n. 7830, p. 516-527, 2020. DOI: https://doi.org/10.1038/s41586-020-2798-3
LAMMERS, T. et al. Nanomedicine for precision medicine: Current state and future perspectives. ACS Nano, v. 14, n. 2, p. 1312-1341, 2020.
PEER, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nature Nanotechnology, v. 2, p. 751-760, 2007. DOI: https://doi.org/10.1038/nnano.2007.387
8
SANTOS, D. S. et al. Nanotechnology-based drug delivery systems against infectious diseases. Journal of Controlled Release, v. 322, p. 303-316, 2020.
SAHOO, S. K.; LABHASETWAR, V. Nanotech approaches to drug delivery and imaging. Drug Discovery Today, v. 8, n. 24, p. 1112-1120, 2003. DOI: https://doi.org/10.1016/S1359-6446(03)02903-9
SILVA, A. C.; LIMA, B. S. Desafios na biodisponibilidade de fármacos e alternativas nanotecnológicas. Revista Brasileira de Farmácia Hospitalar, v. 9, n. 2, p. 44-51, 2018.
TEWARI, R. et al. Dendrimers in drug delivery: A review of current progress. International Journal of Pharmaceutics, v. 548, n. 1, p. 707-720, 2018. DOI: https://doi.org/10.1016/j.ijpharm.2018.07.030
WORLD HEALTH ORGANIZATION (WHO). Global report on nanotechnology and health. Geneva: WHO, 2021.
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Copyright (c) 2025 Geraldo Henrique Kloss de Mello, Júlia Silva Freire, Matheus Carvalho dos Santos, Willemberg Nicolai

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