Nanotecnología aplicada a la química farmacéutica
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https://doi.org/10.61164/hv1ceb36Palabras clave:
Nanotecnología; Química farmacéutica; Nanopartículas; InnovaciónResumen
La nanotecnología es una ciencia en rápida expansión que ha transformado profundamente las industrias farmacéutica y de química medicinal. Al operar a nanoescala, es posible controlar las propiedades fisicoquímicas de los materiales, lo que favorece la biodisponibilidad, la selectividad y la eficacia de los fármacos. Este artículo analiza las principales aplicaciones de la nanotecnología en la química farmacéutica, abordando los sistemas de liberación controlada, los diagnósticos avanzados y las nuevas formulaciones farmacológicas. La investigación se realizó mediante una revisión bibliográfica en bases de datos científicas nacionales e internacionales. Se constató que la nanotecnología ofrece avances significativos en los tratamientos contra el cáncer, las enfermedades infecciosas y las vacunas, pero aún enfrenta desafíos en cuanto a toxicidad, estabilidad y regulación. Además, se observa que el desarrollo de nanosistemas abre nuevas vías para la medicina personalizada, permitiendo terapias más seguras, eficaces e innovadoras, capaces de transformar profundamente el futuro de la farmacoterapia.
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Referencias
ALLEN, T. M.; CULLIS, P. R. Liposomal drug delivery systems: From concept to clinical applications. Advanced Drug Delivery Reviews, v. 65, n. 1, p. 36-48, 2013. DOI: https://doi.org/10.1016/j.addr.2012.09.037
ANVISA. Relatório de Nanotecnologia e Regulação no Brasil. Brasília: ANVISA, 2022.
BHUSHAN, B. Springer Handbook of Nanotechnology. 4. ed. Berlin: Springer, 2017. DOI: https://doi.org/10.1007/978-3-662-54357-3
FERRARI, M. Cancer nanotechnology: Opportunities and challenges. Nature Reviews Cancer, v. 5, n. 3, p. 161-171, 2005. DOI: https://doi.org/10.1038/nrc1566
FERREIRA, L. S. et al. Nanotecnologia e indústria farmacêutica: tendências e perspectivas. Revista Brasileira de Ciências Farmacêuticas, v. 57, n. 2, p. 88-96, 2021.
FONSECA, C. et al. Polymeric nanoparticles for drug delivery: Current developments and future directions. Journal of Biomedical Nanotechnology, v. 14, n. 1, p. 1-19, 2018.
JIANG, W. et al. Nanoparticle-mediated cellular responses: Implications for cancer therapy. Nano Today, v. 35, p. 100937, 2020. DOI: https://doi.org/10.1016/j.nantod.2020.100946
KRAMMER, F. SARS-CoV-2 vaccines in development. Nature, v. 586, n. 7830, p. 516-527, 2020. DOI: https://doi.org/10.1038/s41586-020-2798-3
LAMMERS, T. et al. Nanomedicine for precision medicine: Current state and future perspectives. ACS Nano, v. 14, n. 2, p. 1312-1341, 2020.
PEER, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nature Nanotechnology, v. 2, p. 751-760, 2007. DOI: https://doi.org/10.1038/nnano.2007.387
8
SANTOS, D. S. et al. Nanotechnology-based drug delivery systems against infectious diseases. Journal of Controlled Release, v. 322, p. 303-316, 2020.
SAHOO, S. K.; LABHASETWAR, V. Nanotech approaches to drug delivery and imaging. Drug Discovery Today, v. 8, n. 24, p. 1112-1120, 2003. DOI: https://doi.org/10.1016/S1359-6446(03)02903-9
SILVA, A. C.; LIMA, B. S. Desafios na biodisponibilidade de fármacos e alternativas nanotecnológicas. Revista Brasileira de Farmácia Hospitalar, v. 9, n. 2, p. 44-51, 2018.
TEWARI, R. et al. Dendrimers in drug delivery: A review of current progress. International Journal of Pharmaceutics, v. 548, n. 1, p. 707-720, 2018. DOI: https://doi.org/10.1016/j.ijpharm.2018.07.030
WORLD HEALTH ORGANIZATION (WHO). Global report on nanotechnology and health. Geneva: WHO, 2021.
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Derechos de autor 2025 Geraldo Henrique Kloss de Mello, Júlia Silva Freire, Matheus Carvalho dos Santos, Willemberg Nicolai
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