PHARMACEUTICAL INTERVENTIONS ON MEDICATION ADHERENCE IN ELDERLY INDIVIDUALS WITH CHRONIC DISEASES: AN INTEGRATIVE REVIEW
DOI:
https://doi.org/10.61164/k580cv97Keywords:
Medication adherence, Pharmacist, Elderly, Chronic diseases, TreatmentAbstract
Introduction: This study aimed to synthesize pharmaceutical interventions used to improve medication adherence in elderly individuals with chronic diseases. Therefore, it is important to emphasize that with the aging process comes the emergence of chronic diseases, which constitute one of the main aggravating factors for death and functional restrictions worldwide, thus highlighting the need for pharmaceutical intervention to improve treatment adherence in this population. Method: The research was developed through an integrative literature review, with a qualitative and descriptive approach. The scientific productions were analyzed through a systematic search of the Latin American and Caribbean Literature in Health Sciences (LILACS), Electronic Library Online (SciELO), and United States National Library of Medicine (PubMed) databases, using the following keyword combinations: "medication adherence," "chronic diseases," "elderly," and "pharmaceutical care." These terms were combined using the Boolean operator AND to narrow the results. Results: Based on this, it was possible to identify that the role of the pharmacist is essential in improving medication adherence among elderly individuals with chronic diseases. This can occur through dialogue with the individual about their treatment, as well as individual interviews, counseling on the correct use of medications, and the suggestion of using pill boxes marked with the days of the week. Conclusion: It was evident that the role of the pharmacist is essential for improving medication adherence in patients with chronic diseases.
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AGUIRRE, N. G.; MARTÍNEZ, A. C.; MUÑOZ, L.; AVELLANA, M. C.; MARCO, J. V.; DIEZ-MANGLANO, J. Polypathology, polypharmacy, medication regimen complexity and drug therapy appropriateness. Rev Clin Esp. v. 217, n. 5, pp. 289-295, 2017. DOI: https://doi.org/10.1016/j.rceng.2016.12.008
BAWAB, N.; ZUERCHER, E.; CARRON, T.; CHINET, L.; BUGNON, O.; BERGER, J.; BRIDEVAUX, I. P. Interest in and use of person-centred pharmacy services - a Swiss study of people with diabetes. BMC Health Services Research, v. 21, n. 216, pp. 2-10, 2021. DOI: https://doi.org/10.1186/s12913-021-06217-6
CALDAS, A. L. L.; SÁ, S. P. C.; FILHO, V. C. O. Perceptions of pharmaceutical services among elderly people on polymedication. Revista Brasileira de Enfermagem, v. 73, n. 5, 2020. DOI: https://doi.org/10.1590/0034-7167-2019-0305
CAMPBELL, D. J. T.; MITCHELL, C.; HEMMELGARN, B. R.; TONELLI, M.; FARIS, P.; ZHANG, J.; TSUYUKI, R. T.; FLETCHER, J.; AU, F.; KLARENBACH, S.; EXNER, D. V.; MANNS, B. J. Eliminating Medication Copayments for LowIncome Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial. Circulation. v. 147, pp. 1505–1514, 2023. DOI: https://doi.org/10.1161/CIRCULATIONAHA.123.064188
DUARTE, L. S.; SHIRASSU, M. M.; ATOBE, J. H.; MORAES, M. A.; BERNAL, R. T. I. Continuidade da atenção às doenças crônicas no estado de São Paulo durante a pandemia de Covid-19. Saúde Debate, Rio de Janeiro, v. 45, n. esp. 2, p. 68-81, 2021. DOI: https://doi.org/10.1590/0103-11042021e205
GOVERNO FEDERAL, IBGE, Crescimento da população idosa brasileira expõe urgência de políticas públicas para combater violações e desigualdades, gob.br, Brasília-DF, 2024, disponível em: https://www.gov.br/mdh/pt-br/assuntos/noticias/2024/junho/crescimento-da-populacao-idosa-brasileira-expoe-urgencia-de-politicas-publicas-para-combater-violacoes-e-desigualdades#:~:text=J%C3%A1%20a%20popula%C3%A7%C3%A3o%20idosa%20com,os%2035%20anos%20em%202022. Acesso em: 09 de setembro de 2025.
INÁCIO, R. V. S.; NEVES, N. C. V.; ALMEIDA, J. C. S. AMPARO, T. R.; BITTERNCOURT, M. M; DÔRES, R. G. Dificuldades de idosos na adesão a terapias medicamentosas crônicas, Unidade Básica de Saúde, Congonhas- Brasil. Revista de Salud Pública, v. 21, n. 6, pp. 628-633, 2019.
HO, P. M.; GLORIOSO, T. J.; ALLEN, L. A.; BLANKENHORN, R.; GLASGOW, R. E.; GRUNWALD, G. K.; KHANNA, A.; MAGID, D. J.; PHARMD, J. M.; NOVINS-MONTAGUE, S.; ORLANDO, S.; PETERSON, P.; PLOMONDON, M. E.; SANDY, L. M.; SASEEN, J. J.; TRINKLEY, K. E.; VAUGHN, S.; WAUGHTAL, J.; BULL, S. Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: A Randomized Pragmatic Trial. JAMA, v. 333, n. 1, pp. 49–59, 2025. DOI: https://doi.org/10.1001/jama.2024.21739
HO, P. M.; O'DONNELL C. I.; MCCREIGHT M.; BAVRY, A. A; BOSWORTH, H. B.; GIROTRA, S.; GROSSMAN, M.; HELFRICH, C.; LATIF, F.; LU, D.; MATHENY, M.; MAVROMATIS, K.; ORTIZ, J.; PARASHAR, A.; RATLIFF, D. M.; GRUNWALD, G. K.; GILLETTE, M.; JNEID, H. Intervenção multifacetada para melhorar a adesão ao inibidor P2Y12 após intervenção coronária percutânea: um ensaio clínico em cunha escalonada. J Am Heart Assoc, v. 11, n. 13, 2022. DOI: https://doi.org/10.1161/JAHA.121.024342
HORNE, B. D.; MUHLESTEIN, J. B.; LAPPÉ, D. L.; MAY, H. T.; LE, V. T.; BAIR, T. L.; BABCOCK, D.; BRIDE, D.; KNOWLTON, K. U.; ANDERSON, J. L. Behavioral Nudges as Patient Decision Support for Medication Adherence: The ENCOURAGE Randomized Controlled Trial. Am Heart Journal, v. 244, pp. 125-134, 2022. DOI: https://doi.org/10.1016/j.ahj.2021.11.001
LIMA, E. K. da. S.; LIMA, M. R. da. S. Adesão ao tratamento do Diabetes Mellitus em pacientes da atenção primária à saúde. Arquivos de Ciências da Saúde da UNIPAR. Umuarama. v. 26, n. 3, pp. 643-656, set./dez. 2022. DOI: https://doi.org/10.25110/arqsaude.v26i3.2022.8791
LOURENÇO, R. R. GALVÃO, J. G. F. M.; MARQUES, A. E. F.; NÓBREGA, R. O. A Atuação Do Farmacêutico Frente À Prática De Automedicação Por Idosos No Brasil. Revista Interdisciplinar em Saúde, Cajazeiras, v. 11, n. 1, pp. 853-865, 2024. DOI: https://doi.org/10.35621/23587490.v11.n1.p853-865
LUND, J. L.; GUPTA, P.; AMIN, K. B.; MENG, K.; URICK, B. Y.; REEDER-HAYES, K. E.; FARLEY, J. F.; WHEELER, S. B.; SPEES, L.; TROGDON, J. G. Changes in Chronic Medication Adherence in Older Adults with Cancer Versus Matched Cancer-Free Cohorts. J Geriatr Oncol., v. 12, n. 1, pp. 72–79, 2021. DOI: https://doi.org/10.1016/j.jgo.2020.04.012
OLIVEIRA, G. L.; LULA-BARROS, D. S.; SILVA, D. L. M.; LEITE, S. N. Fatores relacionados à adesão ao tratamento sob a perspectiva da pessoa idosa. Revista Brasileira de Geriatria e Gerontologia, v. 23, n. 4, pp. 1-10, 2020. DOI: https://doi.org/10.1590/1981-22562020023.200160
SANTOS, F. T. C.; SILVA, D. L.; TAVARES, N. U. L. Pharmaceutical clinical services in basic care in a region of the municipality of São Paulo. Braz J Pharm Sci. v. 54, n. 3, pp. 1-11, 2018. DOI: https://doi.org/10.1590/s2175-97902018000317033
SILVA, W. L. F.; GOMES, L. C. G.; SILVÉRIO, M. S. S.; CRUZ, D. T. Fatores associados à não adesão à farmacoterapia em pessoas idosas na atenção primária à saúde no Brasil: uma revisão sistemática. Revista Brasileira de Geriatria e Gerontologia, v. 24, n. 4, pp. 1-15, 2021. DOI: https://doi.org/10.1590/1981-22562021024.210156
TRAINA, S.; ARMANDO, L. G.; DIARASSOUBA, A.; PARISI, R. B.; ESILIATO, M.; ROLANDO, C.; REMANI, E.; COSMO, P.; CENA, C. Proactive inter-disciplinary CME to improve medication management in the elderly population. Research in Social and Administrative Pharmacy, v. 17, pp. 1072-1078, 2021. DOI: https://doi.org/10.1016/j.sapharm.2020.08.005
SILVA, W. L. F.; MATOS, D. M.; FELICÍSSIMO, J. M.; JARDIM, A. C. B.; CRUZ, D. T.; CAZARIM, M. S.; MENDONÇA, A. E.; SILVÉRIO, M. S. Profile of pharmaceutical interventions of a pharmacotherapeutic follow-up model for diabetic patients in a community pharmacy. Brazilian Journal of Pharmaceutical Sciences, v. 58, 2022. DOI: https://doi.org/10.1590/s2175-97902022e20956
WUYTS, J.; MAESSCHALCK, J.; HAMELINCK, W.; WULF, I.; FOULON, V. Does a pharmacist-led medication use review improve medication adherence in polymedicated aged patients? Methodological choices matter! Journal Eval Clin Pract, v. 27, n. 6, 2021. DOI: https://doi.org/10.1111/jep.13567
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