EFECTO DE LA TOXINA BOTULÍNICA TIPO A EN LA DEPRESIÓN: EVIDENCIAS CLÍNICAS Y POSIBLES MECANISMOS NEUROBIOLÓGICOS
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https://doi.org/10.66104/2a6v1q80Palabras clave:
toxina botulínica; depresión; trastorno depresivo mayor; retroalimentación facial; región glabelarResumen
La depresión es una condición psiquiátrica de alta prevalencia y gran impacto funcional, cuya respuesta a los tratamientos convencionales no siempre es satisfactoria. En este contexto, la toxina botulínica tipo A ha sido investigada como una estrategia terapéutica adyuvante en el manejo de la depresión. El objetivo de este estudio fue analizar la evidencia científica disponible sobre el uso de la toxina botulínica tipo A en el tratamiento de la depresión, así como discutir sus posibles mecanismos de acción y aplicaciones en la práctica clínica. Se realizó una revisión narrativa de la literatura en las bases de datos PubMed/MEDLINE, Scopus, Web of Science y SciELO, priorizando estudios publicados en los últimos diez años. Los resultados indican que la aplicación de la toxina, especialmente en la región glabelar, se asocia con una reducción de los síntomas depresivos, posiblemente relacionada con la modulación de las expresiones faciales de emociones negativas, de acuerdo con la teoría del feedback facial. Se concluye que la toxina botulínica tipo A presenta potencial como terapia adyuvante, aunque se requieren más estudios para consolidar su eficacia y aplicabilidad clínica.
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Derechos de autor 2026 Antônio Marcolino Ferreira Segundo, Me. Maurício de Sousa Carvalho Reis, Lilian Abreu Sousa Lopes, Dra. Ludmila Tolstenko Nogueira, Aniele Carvalho Lacerda , Dra. Luciana Tolstenko Nogueira, Kerolayny Lessa de Carvalho Lopes, Maria Eduarda Mousinho Silva Rodrigues
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