MPOX IN PRIMARY HEALTH CARE IN BRAZIL: A SCOPING REVIEW ON SURVEILLANCE, DIAGNOSIS, MANAGEMENT, AND GAPS IN THE SUS RESPONSE
DOI:
https://doi.org/10.66104/hq9p9c76Keywords:
Mpox, Primary Health Care, Health Surveillance, Family Health Strategy, Scoping ReviewAbstract
Objective: to map and synthesize evidence on the role of Primary Health Care (PHC) in surveillance, early diagnosis, clinical management, isolation guidance, referral, health education, and professional training related to mpox, with emphasis on the Brazilian context. Method: exploratory scoping review developed in accordance with Joanna Briggs Institute guidance and structured according to PRISMA-ScR. Searches were carried out in national and international databases and complemented by gray literature, with an initial retrieval of 1,000 records and final inclusion of 80 studies and documents. Results: only four studies directly addressed Brazil, revealing a major gap regarding the role of the Family Health Strategy. The literature indicates that PHC can support early detection, triage, reporting, isolation guidance, outpatient management of mild cases, health education, and coordination with other levels of care; however, important barriers persist, including limited access to molecular diagnosis, lack of PHC-specific protocols, stigma, territorial inequalities, and insufficient training. Conclusion: mpox requires more explicit incorporation into Brazilian PHC workflows, with stronger surveillance, continuing education, integration with referral services, and development of tailored operational protocols.
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ABEJEGAH, C.; OBOHWEMU, K.; MDEGELA, M. Clinical manifestations and outcomes of human mpox infection from 1970 to 2023: a systematic literature review. [S. l.: s. n.], [s. d.].
ABDEL-RAHMAN, S.; BAYICI, B. Z.; KESKE, Ş. et al. Mpox primer for clinicians: what makes the difference in 2024? Current Opinion in Infectious Diseases, [S. l.], 2025. DOI: 10.1097/QCO.0000000000001091. Disponível em: https://doi.org/10.1097/QCO.0000000000001091. DOI: https://doi.org/10.1097/QCO.0000000000001091
AFZAL, M.; SAH, A. K. Effectiveness of public health campaigns on mpox awareness and prevention in rural India. Infectious Diseases in Clinical Practice, [S. l.], 2025. DOI: 10.1097/IPC.0000000000001450. Disponível em: https://doi.org/10.1097/IPC.0000000000001450. DOI: https://doi.org/10.1097/IPC.0000000000001450
AGBOOLA, A.; TAQI, A.; ALSHEIKH, M. et al. Risk factors, preventive measures, and management of monkeypox: a systematic review. Journal of Advances in Medicine and Medical Research, [S. l.], 2025. DOI: 10.9734/jammr/2025/v37i105957. Disponível em: https://doi.org/10.9734/jammr/2025/v37i105957. DOI: https://doi.org/10.9734/jammr/2025/v37i105957
ALFARO-FIERRO, V.; VERGARA, P.; QUIROZ, C. [Mpox virus: from virology to clinical aspects. An update]. Revista Médica de Chile, [S. l.], 2025. DOI: 10.4067/S0034-98872025001000720. Disponível em: https://doi.org/10.4067/S0034-98872025001000720. DOI: https://doi.org/10.4067/s0034-98872025001000720
ALSUBAIE, H. Role of family medicine physicians in management of mpox disease. World Journal of Biology Pharmacy and Health Sciences, [S. l.], 2024. DOI: 10.30574/wjbphs.2024.20.3.0977. Disponível em: https://doi.org/10.30574/wjbphs.2024.20.3.0977. DOI: https://doi.org/10.30574/wjbphs.2024.20.3.0977
ATKINSON, B.; SPENCER, A.; ONIANWA, O. et al. Longitudinal mpox virus surface sampling in an outpatient setting. Journal of Hospital Infection, [S. l.], 2023. DOI: 10.1016/j.jhin.2023.02.007. Disponível em: https://doi.org/10.1016/j.jhin.2023.02.007. DOI: https://doi.org/10.1016/j.jhin.2023.02.007
AYEH, M. A.; COFIE, K.; MENSAH, G. S. et al. Monkeypox infection: risk assessment and clinical outcomes among immunocompromised populations in Sub-Saharan Africa. Ghana Journal of Nursing and Midwifery, [S. l.], 2025. DOI: 10.69600/gjnmid.2024.v01.i04.107-124. Disponível em: https://doi.org/10.69600/gjnmid.2024.v01.i04.107-124. DOI: https://doi.org/10.69600/gjnmid.2024.v01.i04.107-124
BEER, E. M.; RAO, V. A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. PLoS Neglected Tropical Diseases, [S. l.], 2019. DOI: 10.1371/journal.pntd.0007791. Disponível em: https://doi.org/10.1371/journal.pntd.0007791. DOI: https://doi.org/10.1371/journal.pntd.0007791
BEESON, A.; HASTON, J. C.; MCCORMICK, D. et al. Mpox in children and adolescents: epidemiology, clinical features, diagnosis, and management. Pediatrics, [S. l.], 2022. DOI: 10.1542/peds.2022-060179. Disponível em: https://doi.org/10.1542/peds.2022-060179. DOI: https://doi.org/10.1542/peds.2022-060179
BENITES-ZAPATA, V.; ULLOQUE-BADARACCO, J. R.; ALARCÓN-BRAGA, E. A. et al. Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis. Annals of Clinical Microbiology and Antimicrobials, [S. l.], 2022. DOI: 10.1186/s12941-022-00527-1. Disponível em: https://doi.org/10.1186/s12941-022-00527-1. DOI: https://doi.org/10.1186/s12941-022-00527-1
BOGACKA, A.; WROCZYŃSKA, A.; RYMER, W. et al. Mpox unveiled: global epidemiology, treatment advances, and prevention strategies. One Health, [S. l.], 2025. DOI: 10.1016/j.onehlt.2025.101030. Disponível em: https://doi.org/10.1016/j.onehlt.2025.101030. DOI: https://doi.org/10.1016/j.onehlt.2025.101030
BRAGAZZI, N.; KONG, J.; MAHROUM, N. et al. Epidemiological trends and clinical features of the ongoing monkeypox epidemic: a preliminary pooled data analysis and literature review. Journal of Medical Virology, [S. l.], 2022. DOI: 10.1002/jmv.27931. Disponível em: https://doi.org/10.1002/jmv.27931. DOI: https://doi.org/10.1002/jmv.27931
BROCHERO, C. D.; NOCUA-BÁEZ, L. C.; CORTÉS, J. et al. Decoding mpox: a systematic review and meta-analysis of the transmission and severity parameters of the 2022–2023 global outbreak. BMJ Global Health, [S. l.], 2025. DOI: 10.1136/bmjgh-2024-016906. Disponível em: https://doi.org/10.1136/bmjgh-2024-016906. DOI: https://doi.org/10.1136/bmjgh-2024-016906
BUNGE, E.; HOET, B.; CHEN, L. et al. The changing epidemiology of human monkeypox—A potential threat? A systematic review. medRxiv, [S. l.], 2021. DOI: 10.1371/journal.pntd.0010141. Disponível em: https://doi.org/10.1371/journal.pntd.0010141. DOI: https://doi.org/10.1371/journal.pntd.0010141
CADMUS, S.; AKINSEYE, V.; BESONG, M. et al. Dynamics of mpox infection in Nigeria: a systematic review and meta-analysis. Scientific Reports, [S. l.], 2024. DOI: 10.1038/s41598-024-58147-y. Disponível em: https://doi.org/10.1038/s41598-024-58147-y. DOI: https://doi.org/10.1038/s41598-024-58147-y
CADNUM, J.; OSBORNE, A.; MEMIC, S. et al. Healthcare personnel with laboratory-confirmed mpox in California. Antimicrobial Stewardship and Healthcare Epidemiology, [S. l.], 2023. DOI: 10.1017/ash.2023.313. Disponível em: https://doi.org/10.1017/ash.2023.313. DOI: https://doi.org/10.1017/ash.2023.313
CARDOSO, M. E.; COSTA, A.; BINELLI, C. et al. Severe monkeypox case associated with recent laboratory diagnosis of HIV: case report. Jornal Brasileiro de Doenças Sexualmente Transmissíveis, [S. l.], 2022. DOI: 10.5327/dst-2177-8264-2022341215. Disponível em: https://doi.org/10.5327/dst-2177-8264-2022341215. DOI: https://doi.org/10.5327/DST-2177-8264-2022341215
CASTANHEIRA, A. C. M.; MOREIRA, C. C. D.; DAMASCENO, K. G. et al. The nurse's action in front of the suspect and/or confirmation of monkeypox disease. International Journal of Health Sciences, [S. l.], 2023. DOI: 10.22533/at.ed.159352320019. Disponível em: https://doi.org/10.22533/at.ed.159352320019. DOI: https://doi.org/10.22533/at.ed.159352320019
CHEEMA, A. Y.; OGEDEGBE, O.; MUNIR, M. et al. Monkeypox: a review of clinical features, diagnosis, and treatment. Cureus, [S. l.], 2022. DOI: 10.7759/cureus.26756. Disponível em: https://doi.org/10.7759/cureus.26756. DOI: https://doi.org/10.7759/cureus.26756
CHENCHULA, S.; GHANTA, M.; AMERNENI, K. et al. A systematic review to identify novel clinical characteristics of monkeypox virus infection and therapeutic and preventive strategies to combat the virus. Archives of Virology, [S. l.], 2023. DOI: 10.1007/s00705-023-05808-4. Disponível em: https://doi.org/10.1007/s00705-023-05808-4. DOI: https://doi.org/10.1007/s00705-023-05808-4
CHEUYEM, F. Z. L.; TAKPANDO-LE-GRAND, D. R.; ACHANGWA, C. et al. Mpox clinical and epidemiological patterns in the Central African Republic: a systematic review and meta-analysis. medRxiv, [S. l.], 2025. DOI: 10.1101/2025.07.09.25331215. Disponível em: https://doi.org/10.1101/2025.07.09.25331215. DOI: https://doi.org/10.1101/2025.07.09.25331215
CHUKWUYEM, A.; OBOHWEMU, K.; MDEGELA, M. Clinical manifestations and outcome of human mpox infection from 1970 to 2023: a systematic literature review. Clinical Infection in Practice, [S. l.], 2024. DOI: 10.1016/j.clinpr.2024.100397. Disponível em: https://doi.org/10.1016/j.clinpr.2024.100397. DOI: https://doi.org/10.1016/j.clinpr.2024.100397
CLEMENTE, N. S.; COLES, C.; PAIXÃO, E. et al. Paediatric, maternal, and congenital mpox: a systematic review and meta-analysis. Lancet Global Health, [S. l.], 2024. DOI: 10.1016/S2214-109X(23)00607-1. Disponível em: https://doi.org/10.1016/S2214-109X(23)00607-1. DOI: https://doi.org/10.1016/S2214-109X(23)00607-1
CORNELISSE, V. J.; HEATH-PAYNTER, D.; DELPECH, V. et al. How Australia and Aotearoa New Zealand avoided large-scale mpox (formerly monkeypox) outbreaks in 2022–2023. Internal Medicine Journal, [S. l.], 2023. DOI: 10.1111/imj.16236. Disponível em: https://doi.org/10.1111/imj.16236. DOI: https://doi.org/10.1111/imj.16236
COSTA, L. M. F.; SARAIVA, A. G. T.; SILVA, J. et al. Oral manifestations of monkeypox infection: clinical implications for dental diagnosis and management in emerging viral outbreaks in Brazil. Brazilian Journal of Implantology and Health Sciences, [S. l.], 2025. DOI: 10.36557/2674-8169.2025v7n5p1391-1398. Disponível em: https://doi.org/10.36557/2674-8169.2025v7n5p1391-1398. DOI: https://doi.org/10.36557/2674-8169.2025v7n5p1391-1398
CUETOS-SUÁREZ, D.; GAN, R. K.; CUETOS-SUÁREZ, D. et al. A review of mpox outbreak and public health response in Spain. Risk Management and Healthcare Policy, [S. l.], 2024. DOI: 10.2147/RMHP.S440035. Disponível em: https://doi.org/10.2147/RMHP.S440035. DOI: https://doi.org/10.2147/RMHP.S440035
DA SILVA, K.; GRANZOTTI, R. B.; CÉSAR, C. P. H. A. R. et al. Emerging challenges of mpox transmission: an in-depth scoping review and evidence mapping on breastfeeding practices in South America. The Pediatric Infectious Disease Journal, [S. l.], 2024. DOI: 10.1097/INF.0000000000004432. Disponível em: https://doi.org/10.1097/INF.0000000000004432. DOI: https://doi.org/10.1097/INF.0000000000004432
DANTAS, A. C.; SILVA, C. L. B.; ALVES, D. L. B. S. et al. Clinical aspects of human mpox cases in the global scenario: an integrative review. Revista Cuidarte, [S. l.], 2024. DOI: 10.15649/cuidarte.3610. Disponível em: https://doi.org/10.15649/cuidarte.3610. DOI: https://doi.org/10.15649/cuidarte.3610
DÍAZ-BROCHERO, C.; CUCUNUBÁ, Z. Epidemiological findings, estimates of the instantaneous reproduction number, and control strategies of the first mpox outbreak in Latin America. Travel Medicine and Infectious Disease, [S. l.], 2024. DOI: 10.1016/j.tmaid.2024.102701. Disponível em: https://doi.org/10.1016/j.tmaid.2024.102701. DOI: https://doi.org/10.1016/j.tmaid.2024.102701
DOLGOPOLOV, I.; RYKOV, M.; HAMTSOVA, Z. V. Monkeypox - exotic infection outbreak or a new global challenge to global health system? Epidemiology and Infectious Diseases, [S. l.], 2022. DOI: 10.17816/eid108550. Disponível em: https://doi.org/10.17816/eid108550. DOI: https://doi.org/10.17816/EID108550
EFFIONG, F.; ELEBESUNU, E. E.; OGUNNIYI, T. et al. Strengthening mpox laboratory surveillance and response mechanisms in Central and West Africa: a comprehensive scoping review. Journal of Interventional Epidemiology and Public Health, [S. l.], 2025. DOI: 10.37432/jieph-confpro5-00092. Disponível em: https://doi.org/10.37432/jieph-confpro5-00092. DOI: https://doi.org/10.37432/JIEPH-CONFPRO5-00092
EZEH, I.; HAIGH, D. A.; MAY, R.; JACOBS, N. P035 symptom-based de-isolation with patient-centred virtual review of rash resolution: a retrospective cohort study of patients with mpox (monkeypox) managed in a virtual ward. Posters, [S. l.], 2023. DOI: 10.1136/sextrans-bashh-2023.75. Disponível em: https://doi.org/10.1136/sextrans-bashh-2023.75. DOI: https://doi.org/10.1136/sextrans-BASHH-2023.75
GANDHI, A.; PADHI, B.; SANDEEP, M. et al. Monkeypox patients living with HIV: a systematic review and meta-analysis of geographic and temporal variations. Epidemiologia, [S. l.], 2023. DOI: 10.3390/epidemiologia4030033. Disponível em: https://doi.org/10.3390/epidemiologia4030033. DOI: https://doi.org/10.3390/epidemiologia4030033
GANDHI, A. P.; PATRO, S.; SANDEEP, M. et al. Oral manifestation of the monkeypox virus: a systematic review and meta-analysis. EClinicalMedicine, [S. l.], 2023. DOI: 10.1016/j.eclinm.2022.101817. Disponível em: https://doi.org/10.1016/j.eclinm.2022.101817. DOI: https://doi.org/10.1016/j.eclinm.2022.101817
GHAZY, R.; HAMMAD, E.; HALL, M. A. et al. How can imported monkeypox break the borders? A rapid systematic review. Comparative Immunology, Microbiology & Infectious Diseases, [S. l.], 2022. DOI: 10.1016/j.cimid.2022.101923. Disponível em: https://doi.org/10.1016/j.cimid.2022.101923. DOI: https://doi.org/10.1016/j.cimid.2022.101923
GUARDUCCI, G.; PORCHIA, B.; LORENZINI, C.; NANTE, N. Overview of case definitions and contact tracing indications in the 2022 monkeypox outbreak. Le Infezioni in Medicina, [S. l.], 2023. DOI: 10.53854/liim-3101-3. Disponível em: https://doi.org/10.53854/liim-3101-3. DOI: https://doi.org/10.53854/liim-3101-3
HALLO-CARRASCO, A.; HUNT, C. L.; PRUSINSKI, C. C. et al. Pain associated with monkeypox virus: a rapid review. Cureus, [S. l.], 2023. DOI: 10.7759/cureus.34697. Disponível em: https://doi.org/10.7759/cureus.34697. DOI: https://doi.org/10.7759/cureus.34697
HARAPAN, H.; OPHINNI, Y.; MEGAWATI, D. et al. Monkeypox: a comprehensive review. Viruses, [S. l.], 2022. DOI: 10.3390/v14102155. Disponível em: https://doi.org/10.3390/v14102155. DOI: https://doi.org/10.3390/v14102155
HATAMI, H.; JAMSHIDI, P.; ARBABI, M. et al. Demographic, epidemiologic, and clinical characteristics of human monkeypox disease pre- and post-2022 outbreaks: a systematic review and meta-analysis. Biomedicines, [S. l.], 2023. DOI: 10.3390/biomedicines11030957. Disponível em: https://doi.org/10.3390/biomedicines11030957. DOI: https://doi.org/10.3390/biomedicines11030957
JADHAV, V.; PAUL, A.; TRIVEDI, V. et al. Global epidemiology, viral evolution, and public health responses: a systematic review on mpox (1958–2024). Journal of Global Health, [S. l.], 2025. DOI: 10.7189/jogh.15.04061. Disponível em: https://doi.org/10.7189/jogh.15.04061. DOI: https://doi.org/10.7189/jogh.15.04061
JAHROMI, A. S.; JOKAR, M.; SHARIFI, N. et al. Global knowledge and attitudes towards mpox (monkeypox) among healthcare workers: a systematic review and meta-analysis. International Health, [S. l.], 2023. DOI: 10.1093/inthealth/ihad094. Disponível em: https://doi.org/10.1093/inthealth/ihad094. DOI: https://doi.org/10.1093/inthealth/ihad094
KAUR, R.; GUPTA, S.; PATHAK, S. et al. A primer on monkeypox infection: an emerging threat to global public health. Archives of Medical Research, [S. l.], 2025. DOI: 10.1016/j.arcmed.2025.103279. Disponível em: https://doi.org/10.1016/j.arcmed.2025.103279. DOI: https://doi.org/10.1016/j.arcmed.2025.103279
KAYA, E.; ŞAHIN, M.; SOLAK, Y. et al. An overview of monkeypox outbreak. Central Asian Journal of Medical Hypotheses and Ethics, [S. l.], 2023. DOI: 10.47316/cajmhe.2023.4.1.01. Disponível em: https://doi.org/10.47316/cajmhe.2023.4.1.01. DOI: https://doi.org/10.47316/cajmhe.2023.4.1.01
KHAN, M. I.; SALEH, A.; ALI, R. et al. The evolving mpox threat (2022-2024): clade dynamics, immune evasion, and escalating global health challenges. Frontiers in Cellular and Infection Microbiology, [S. l.], 2026. DOI: 10.3389/fcimb.2025.1677762. Disponível em: https://doi.org/10.3389/fcimb.2025.1677762. DOI: https://doi.org/10.3389/fcimb.2025.1677762
KRÖGER, S. T.; LEHMANN, M.; TREUTLEIN, M. et al. Mpox outbreak 2022: an overview of all cases reported to the Cologne Health Department. Infection, [S. l.], 2023. DOI: 10.1007/s15010-023-01997-x. Disponível em: https://doi.org/10.1007/s15010-023-01997-x. DOI: https://doi.org/10.1007/s15010-023-01997-x
KUEHN, R.; FOX, T.; GUYATT, G. et al. Infection prevention and control measures to reduce the transmission of mpox: a systematic review. medRxiv, [S. l.], 2023. DOI: 10.1101/2023.02.13.23285871. Disponível em: https://doi.org/10.1101/2023.02.13.23285871. DOI: https://doi.org/10.1101/2023.02.13.23285871
KUEHN, R.; FOX, T.; GUYATT, G. et al. Infection prevention and control measures to reduce the transmission of mpox: a systematic review. PLOS Global Public Health, [S. l.], 2024. DOI: 10.1371/journal.pgph.0002731. Disponível em: https://doi.org/10.1371/journal.pgph.0002731. DOI: https://doi.org/10.1371/journal.pgph.0002731
LAZARUS, J. E.; GREEN, C. V.; ALBIN, J. et al. 1786. Separating the rash from the chaff: novel clinical decision support deployed during the mpox outbreak. Open Forum Infectious Diseases, [S. l.], 2023. DOI: 10.1093/ofid/ofad500.1615. Disponível em: https://doi.org/10.1093/ofid/ofad500.1615. DOI: https://doi.org/10.1093/ofid/ofad500.1615
LEÓN-FIGUEROA, D. A.; BARBOZA, J. J.; SIDDIQ, A. et al. Knowledge and attitude towards mpox: systematic review and meta-analysis. PLoS ONE, [S. l.], 2024. DOI: 10.1371/journal.pone.0308478. Disponível em: https://doi.org/10.1371/journal.pone.0308478. DOI: https://doi.org/10.1371/journal.pone.0308478
LEÓN-FIGUEROA, D. A.; BARBOZA, J. J.; VALLADARES-GARRIDO, M. J. et al. Prevalence of intentions to receive monkeypox vaccine: a systematic review and meta-analysis. BMC Public Health, [S. l.], 2024. DOI: 10.1186/s12889-023-17473-y. Disponível em: https://doi.org/10.1186/s12889-023-17473-y. DOI: https://doi.org/10.1186/s12889-023-17473-y
LEPELLETIER, D.; POZZETTO, B.; CHAUVIN, F.; CHIDIAC, C. Management of patients with monkeypox virus infection and contacts in the community and in healthcare settings: a French position paper. Clinical Microbiology and Infection, [S. l.], 2022. DOI: 10.1016/j.cmi.2022.08.018. Disponível em: https://doi.org/10.1016/j.cmi.2022.08.018. DOI: https://doi.org/10.1016/j.cmi.2022.08.018
LEVITT, C. V.; TRAN, Q.; HRAKY, H. et al. Emergency department approach to monkeypox. World Journal of Emergency Medicine, [S. l.], 2023. DOI: 10.5847/wjem.j.1920-8642.2023.098. Disponível em: https://doi.org/10.5847/wjem.j.1920-8642.2023.098. DOI: https://doi.org/10.5847/wjem.j.1920-8642.2023.098
LI, P.; LI, J.; AYADA, I. et al. Clinical features, antiviral treatment, and patient outcomes: a systematic review and comparative analysis of the previous and the 2022 mpox outbreaks. Journal of Infectious Diseases, [S. l.], 2023. DOI: 10.1093/infdis/jiad034. Disponível em: https://doi.org/10.1093/infdis/jiad034. DOI: https://doi.org/10.1093/infdis/jiad034
LIRA, G. S.; OTA, V. A.; MELO, M. Q. S. et al. Mpox outbreak in Rio de Janeiro, Brazil: a translational approach. Journal of Medical Virology, [S. l.], 2024. DOI: 10.1002/jmv.29621. Disponível em: https://doi.org/10.1002/jmv.29621. DOI: https://doi.org/10.1002/jmv.29621
LIU, Q.; FU, L.; WANG, B. et al. Clinical characteristics of human mpox (monkeypox) in 2022: a systematic review and meta-analysis. Pathogens, [S. l.], 2023. DOI: 10.3390/pathogens12010146. Disponível em: https://doi.org/10.3390/pathogens12010146. DOI: https://doi.org/10.3390/pathogens12010146
MAREDIA, H.; SARTORI-VALINOTTI, J.; RANGANATH, N. et al. Supportive care management recommendations for mucocutaneous manifestations of monkeypox infection. Mayo Clinic Proceedings, [S. l.], 2023. DOI: 10.1016/j.mayocp.2023.01.019. Disponível em: https://doi.org/10.1016/j.mayocp.2023.01.019. DOI: https://doi.org/10.1016/j.mayocp.2023.01.019
MCNAUGHTON, A.; KARSENTI, N.; KWAN, J. et al. Primary varicella infection in a young adult from the Democratic Republic of the Congo: a case report and mini-review. Infectious Disease Reports, [S. l.], 2024. DOI: 10.3390/idr16040048. Disponível em: https://doi.org/10.3390/idr16040048. DOI: https://doi.org/10.3390/idr16040048
MUSHEBENGE, A. G.; MPHUTHI, D. Emerging insights into monkeypox: clinical features, epidemiology, molecular insights, and advancements in management. BioMed, [S. l.], 2025. DOI: 10.3390/biomed5030021. Disponível em: https://doi.org/10.3390/biomed5030021. DOI: https://doi.org/10.3390/biomed5030021
OGOINA, D.; DAMON, I.; NAKOUNE, E. Clinical review of human mpox. Clinical Microbiology and Infection, [S. l.], 2023. DOI: 10.1016/j.cmi.2023.09.004. Disponível em: https://doi.org/10.1016/j.cmi.2023.09.004. DOI: https://doi.org/10.1016/j.cmi.2023.09.004
OIWOH, S.; IBEKWE, P.; AJANI, A. et al. Systemic and dermatologic impact of mpox: an overview of guideline-based management for Nigerian healthcare workers. Nigerian Medical Journal, [S. l.], 2023.
OKEREKE, P.; TERRA, M.; OKEREKE, W. et al. The implications of mpox for healthcare providers: understanding transmission, clinical presentation, and infection control. Decoding Infection and Transmission, [S. l.], 2025. DOI: 10.1016/j.dcit.2025.100049. Disponível em: https://doi.org/10.1016/j.dcit.2025.100049. DOI: https://doi.org/10.1016/j.dcit.2025.100049
OKOLI, G.; CAESEELE, P.; ASKIN, N.; ABOU-SETTA, A. A global systematic evidence review with meta-analysis of the epidemiological characteristics of the 2022 mpox outbreaks. Infection, [S. l.], 2023. DOI: 10.1007/s15010-023-02133-5. Disponível em: https://doi.org/10.1007/s15010-023-02133-5. DOI: https://doi.org/10.1007/s15010-023-02133-5
OKOLI, G.; VAN CAESEELE, P. V.; ASKIN, N.; ABOU-SETTA, A. Comparative evaluation of the clinical presentation and epidemiology of the 2022 and previous mpox outbreaks: a rapid review and meta-analysis. Infectious Diseases, [S. l.], 2023. DOI: 10.1080/23744235.2023.2214609. Disponível em: https://doi.org/10.1080/23744235.2023.2214609. DOI: https://doi.org/10.1080/23744235.2023.2214609
OKOLI, G.; VAN CAESEELE, P.; ASKIN, N.; ABOU-SETTA, A. Epidemiological characteristics of the 2022 mpox outbreaks: a comprehensive global systematic evidence review with meta-analysis. International Journal of Infectious Diseases, [S. l.], 2025. DOI: 10.1016/j.ijid.2024.107574. Disponível em: https://doi.org/10.1016/j.ijid.2024.107574. DOI: https://doi.org/10.1016/j.ijid.2024.107574
OMAM, L.; JARMAN, E.; MALIK, F. et al. Containment and response strategies for mpox outbreaks: a systematic review. BMC Infectious Diseases, [S. l.], 2025. DOI: 10.1186/s12879-025-12281-8. Disponível em: https://doi.org/10.1186/s12879-025-12281-8. DOI: https://doi.org/10.1186/s12879-025-12281-8
ONODERA, A.; IMAI, K.; SATO, A. et al. Retrospective investigation of overlooked mpox virus infection in saliva samples from patients with suspected syphilis in Japan. Journal of Medical Virology, [S. l.], 2024. DOI: 10.1002/jmv.29663. Disponível em: https://doi.org/10.1002/jmv.29663. DOI: https://doi.org/10.1002/jmv.29663
PAPARINI, S.; WHELAN, I.; MWENDERA, C. et al. Prevention of sexual transmission of mpox: a systematic review and qualitative evidence synthesis of approaches. Infectious Diseases, [S. l.], 2024. DOI: 10.1080/23744235.2024.2364801. Disponível em: https://doi.org/10.1080/23744235.2024.2364801. DOI: https://doi.org/10.1080/23744235.2024.2364801
PATHELA, P.; NAGAO, K.; BRAUNSTEIN, S. L. Public health surveillance and outbreak preparedness for mpox. Current Opinion in HIV and AIDS, [S. l.], 2025. DOI: 10.1097/COH.0000000000001005. Disponível em: https://doi.org/10.1097/COH.0000000000001005. DOI: https://doi.org/10.1097/COH.0000000000001005
PEREIRA, S. S.; BRAGA, A.; ROSOLEN, B. B. et al. Maternal-fetal implications of mpox infection: current evidence. Journal of Clinical Medicine, [S. l.], 2026. DOI: 10.3390/jcm15010399. Disponível em: https://doi.org/10.3390/jcm15010399. DOI: https://doi.org/10.3390/jcm15010399
RAHMAN, M. M. Systematic review of the epidemiology, disease severity and preventive measures of mpox disease: a public health guideline for densely-populated countries. F1000Research, [S. l.], 2024. DOI: 10.12688/f1000research.150476.1. Disponível em: https://doi.org/10.12688/f1000research.150476.1. DOI: https://doi.org/10.12688/f1000research.150476.1
SANDOVAL-URBANO, E.; PIMENTEL-BETANCOURT, J. E.; LOZANO-GUTIERRES, K. M. et al. Mpox: transmission, clinical manifestations, prevention, and treatment – a narrative review. AG Salud, [S. l.], 2025. DOI: 10.62486/agsalud2025182. Disponível em: https://doi.org/10.62486/agsalud2025182. DOI: https://doi.org/10.62486/agsalud2025182
SANKAR, S.; BALAKRISHNAN, P.; YONG, Y. et al. Mpox virus as a global public health emergency: a scoping review. The Canadian Journal of Infectious Diseases & Medical Microbiology, [S. l.], 2025. DOI: 10.1155/cjid/6683501. Disponível em: https://doi.org/10.1155/cjid/6683501. DOI: https://doi.org/10.1155/cjid/6683501
SUN, Y.; NIE, W.; TIAN, D.; YE, Q. Human monkeypox virus: epidemiologic review and research progress in diagnosis and treatment. Journal of Clinical Virology, [S. l.], 2024. DOI: 10.1016/j.jcv.2024.105662. Disponível em: https://doi.org/10.1016/j.jcv.2024.105662. DOI: https://doi.org/10.1016/j.jcv.2024.105662
THORNHILL, J.; PALICH, R.; GHOSN, J. et al. Human monkeypox virus infection in women during the 2022 outbreaks: a global case series. Social Science Research Network, [S. l.], 2022. DOI: 10.2139/ssrn.4254904. Disponível em: https://doi.org/10.2139/ssrn.4254904. DOI: https://doi.org/10.2139/ssrn.4254904
TITANJI, B. K.; HAZRA, A.; ZUCKER, J. Mpox clinical presentation, diagnostic approaches, and treatment strategies: a review. JAMA, [S. l.], 2024. DOI: 10.1001/jama.2024.21091. Disponível em: https://doi.org/10.1001/jama.2024.21091. DOI: https://doi.org/10.1001/jama.2024.21091
WEBB, E.; RIGBY, I.; MICHELEN, M. et al. Availability, scope and quality of monkeypox clinical management guidelines globally: a systematic review. BMJ Global Health, [S. l.], 2022. DOI: 10.1136/bmjgh-2022-009838. Disponível em: https://doi.org/10.1136/bmjgh-2022-009838. DOI: https://doi.org/10.1136/bmjgh-2022-009838
YADAV, P.; REGHUKUMAR, A.; SAHAY, R. et al. First two cases of monkeypox virus infection in travellers returned from UAE to India, July 2022. Journal of Infection, [S. l.], 2022. DOI: 10.1016/j.jinf.2022.08.007. Disponível em: https://doi.org/10.1016/j.jinf.2022.08.007. DOI: https://doi.org/10.1016/j.jinf.2022.08.007
YON, H.; SHIN, H.-M.; SHIN, J. et al. Clinical manifestations of human mpox infection: a systematic review and meta-analysis. Reviews in Medical Virology, [S. l.], 2023. DOI: 10.1002/rmv.2446. Disponível em: https://doi.org/10.1002/rmv.2446. DOI: https://doi.org/10.1002/rmv.2446
ZAMORA, E. M. E.; VELASTEGUÍ, V. G. S.; CHÁVEZ, M. B. T. et al. Epidemiología, clínica y prevención de la viruela símica: revisión bibliográfica. Salud, Ciencia y Tecnología, [S. l.], 2024. DOI: 10.56294/saludcyt2024810. Disponível em: https://doi.org/10.56294/saludcyt2024810. DOI: https://doi.org/10.56294/saludcyt2024810
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Copyright (c) 2026 Vinicius de Lima Lovadini, Fernando Deungaro De Mendonca, Patrícia Michelassi Carrinho Aureliano, Ana Paula de Lima , Evelise Pires Cogo Simão, Vanessa Dias de Oliveira Justi, Livia Moreira da Silva, Ana Elisa Pereira da Silva , Tharinne Oliveira Silva Cavalheiro, Valter Mariano dos Santos Junior , Nicezia Vilela Junqueira Franqueiro, Luana Biancardini, Nínive Xisto de Souza , Thaisa Silva de Sousa
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