COLELITIASIS EN PACIENTES DESPUÉS DE CIRUGÍA BARIÁTRICA: REVISIÓN DE LA LITERATURA

Autores/as

  • GEYZA CAROLINE OLIVEIRA PINTO PINTO Universidade Federal do Maranhão (UFMA), Brasil
  • GUTEMBERG FERNANDES DE ARAÚJO Universidade Federal do Maranhão (UFMA), Brasil

DOI:

https://doi.org/10.66104/k7tssa54

Palabras clave:

obesidad; colelitiasis; cirugía bariátrica.

Resumen

La obesidad se caracteriza por la acumulación excesiva de grasa corporal capaz de comprometer la salud, y se clasifica según el índice de masa corporal (IMC) en eutrofia (18–24,9 kg/m²), sobrepeso (25–29,9 kg/m²) y obesidad grado I a III (≥30 kg/m²). Desde 1975, su prevalencia mundial se ha triplicado, afectando a más de 1.000 millones de personas. La cirugía bariátrica constituye una alternativa eficaz para pacientes refractarios a tratamientos conservadores. La enfermedad biliar no neoplásica, incluida la colelitiasis, es una complicación frecuente en el postoperatorio de la cirugía bariátrica, resultante de múltiples mecanismos litogénicos, como la rápida pérdida de peso, el aumento de la liberación de colesterol y lípidos desde los adipocitos y la reducción del IMC preoperatorio ≥25%. El objetivo de este estudio fue analizar, mediante una revisión de la literatura, la relación entre la enfermedad biliar no neoplásica y la obesidad, enfatizando los factores de riesgo, los mecanismos fisiopatológicos y la indicación de colecistectomía concomitante a la cirugía bariátrica. Se seleccionaron 20 artículos publicados a partir de 2003, obtenidos de las bases de datos PubMed, SciELO y LILACS, utilizando los descriptores bariatric, cholelithiasis y obesity. La incidencia de colelitiasis post-bariátrica varió entre 1,4% y 55,5%, con mayor riesgo en mujeres, pacientes con rápida pérdida de peso, multiparidad o uso de anticonceptivos orales. Entre los factores protectores se incluyen la edad avanzada, el uso de estatinas y la profilaxis con ácido ursodesoxicólico. La colelitiasis tiende a ocurrir durante los primeros seis meses posteriores a la cirugía, siendo más frecuente tras el bypass gástrico. La colecistectomía concomitante se considera segura, estando especialmente indicada en pacientes con cálculos biliares preexistentes.

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Referencias

AGUIAR, R. G. P. de et al. Clinical and epidemiological evaluation of complications associated with gallstones in a tertiary hospital. Arquivos de Gastroenterologia, v. 59, n. 3, 2022. DOI: https://doi.org/10.1590/S0004-2803.202200000-59 DOI: https://doi.org/10.1590/s0004-2803.202203000-64

ALDRIWEESH, Mohammed A. et al. The incidence and risk factors of cholelithiasis development after bariatric surgery in Saudi Arabia: a two-center retrospective cohort study. Frontiers in Surgery, v. 7, 2020. DOI: https://doi.org/10.3389/fsurg.2020.559064 DOI: https://doi.org/10.3389/fsurg.2020.559064

ALSAIF, Faisal A. et al. Incidence of symptomatic cholelithiasis after laparoscopic sleeve gastrectomy and its association with rapid weight loss. Saudi Journal of Gastroenterology, 2020. DOI: https://doi.org/10.4103/sjg.SJG_472_19

ANVEDEN, Asa et al. Long-term incidence of gallstone disease after bariatric surgery: results from the Swedish Obese Subjects study. Surgery for Obesity and Related Diseases, v. 16, p. 1474–1482, 2020. DOI:https://doi.org/10.1016/j.soard.2020.05.025 DOI: https://doi.org/10.1016/j.soard.2020.05.025

BOERLAGE, Thomas C. C. et al. Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: study protocol for a randomized controlled trial (UPGRADE trial). BMC Gastroenterology, v. 17, n. 1, 2017. DOI: https://doi.org/10.1186/s12876-017-0632-5

BRASIL. Ministério da Saúde. Secretaria de Vigilância em Saúde. Vigitel Brasil 2020: vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico. Brasília: Ministério da Saúde, 2021.

BRASIL. Ministério da Saúde. Pesquisa Nacional de Saúde (PNS) 2020. Brasília: MS, 2020.

BRASIL. Ministério da Saúde. Sistema de Vigilância Alimentar e Nutricional (SISVAN). Brasília: MS, 2024.

CABRERA CHAMORRO, C. C. et al. Cholelithiasis and associated complications. Cirugía Pediátrica, v. 33, n. 2, 2020.

CARVALHO, M. R.; SANTOS, J. L. Diagnóstico por imagem das doenças biliares. Radiologia Brasileira, 2020.

COSTA, T. N.; FREITAS, A. C. Colecistectomia profilática em cirurgia bariátrica: revisão. Revista do Colégio Brasileiro de Cirurgiões, 2020.

COUPAYE, M. et al. Comparison of the incidence of cholelithiasis after sleeve gastrectomy and Roux-en-Y gastric bypass in obese patients: a prospective study. Surgery for Obesity and Related Diseases, v. 11, n. 4, p. 779–784, 2015. DOI: https://doi.org/10.1016/j.soard.2015.01.005 DOI: https://doi.org/10.1016/j.soard.2014.10.015

D’HONDT, M. et al. Laparoscopic sleeve gastrectomy as a single-stage procedure for the treatment of morbid obesity. Obesity Surgery, v. 21, n. 6, p. 722–727, 2011. DOI: https://doi.org/10.1007/s11695-010-0330-3

GERO, Daniel et al. Long-term incidence of gallstone disease after bariatric surgery. Annals of Surgery, v. 270, n. 5, p. 859–867, 2019. DOI: https://doi.org/10.1097/SLA.0000000000003504 DOI: https://doi.org/10.1097/SLA.0000000000003504

GUMAN, M. S. S. et al. Adipose tissue, bile acids, and gut microbiome species associated with gallstones after bariatric surgery. Journal of Lipid Research, 2022. DOI: https://doi.org/10.1016/j.jlr.2022.100164 DOI: https://doi.org/10.1016/j.jlr.2022.100280

HAAL, Sylke et al. Risk factors for symptomatic gallstone disease and gallstone formation after bariatric surgery. Obesity Surgery, v. 32, n. 4, p. 1270–1278, 2022. DOI: https://doi.org/10.1007/s11695-021-05831-2 DOI: https://doi.org/10.1007/s11695-022-05947-8

HAAL, Sylke et al. Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery (UPGRADE trial). The Lancet Gastroenterology & Hepatology, v. 6, n. 12, 2021. DOI: https://doi.org/10.1016/S2468-1253(21)00249-4

OLIVEIRA, C. I. B. et al. Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obesity Surgery, v. 13, n. 4, 2003. DOI: https://doi.org/10.1381/096089203322190781 DOI: https://doi.org/10.1381/096089203322190862

KIM, Hyung Sun et al. Big data analysis of risk factors for gallbladder disease in young adults. PLOS ONE, v. 14, n. 2, 2019. DOI: https://doi.org/10.1371/journal.pone.0211480 DOI: https://doi.org/10.1371/journal.pone.0213950

KUBICA, Krystian; BALBUS, Joanna. Cholesterol gallstone risk associated with obesity and normal weight. Scientific Reports, v. 11, 2021. DOI: https://doi.org/10.1038/s41598-021-81273-9 DOI: https://doi.org/10.1038/s41598-021-88249-w

LEMOS, L. N.; TAVARES, R. M. F.; DONADELLI, C. A. D. M. Perfil epidemiológico de pacientes com colelitíase atendidos em ambulatório de cirurgia. Revista Eletrônica Acervo Saúde, v. 28, 2019. DOI: https://doi.org/10.25248/reas.e1230.2019 DOI: https://doi.org/10.25248/reas.e947.2019

LIU, Tong et al. Relationship between high-sensitivity C-reactive protein and gallstone risk. BMJ Open, v. 10, n. 9, 2020. DOI: https://doi.org/10.1136/bmjopen-2020-037351 DOI: https://doi.org/10.1136/bmjopen-2019-035880

MACHADO, F. H. F. et al. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass. Acta Cirúrgica Brasileira, v. 34, n. 1, 2019. DOI: https://doi.org/10.1590/s0102-865020190010000007 DOI: https://doi.org/10.1590/s0102-865020190010000009

MOON, R. C. et al. Management of gallbladder disease in bariatric surgery. Surgery for Obesity and Related Diseases, v. 10, n. 3, p. 481–486, 2014. DOI: https://doi.org/10.1016/j.soard.2013.10.010 DOI: https://doi.org/10.1016/j.soard.2013.10.010

NGUYEN, N. T. et al. Bariatric surgery for obesity and metabolic disorders. Nature Reviews Gastroenterology & Hepatology, v. 14, n. 3, p. 160–169, 2016. DOI: https://doi.org/10.1038/nrgastro.2016.170 DOI: https://doi.org/10.1038/nrgastro.2016.170

PATEL, K. et al. Association between obesity and gallstone disease: a systematic review. Cureus, v. 14, n. 1, 2022. DOI: https://doi.org/10.7759/cureus.21056 DOI: https://doi.org/10.7759/cureus.21056

RODRIGUES, R. M. et al. Ursodeoxycholic acid in prevention of gallstones after bariatric surgery. Acta Cirúrgica Brasileira, 2018.

SHENG, B. et al. Weight and asymptomatic gallbladder stones in hypercholesterolemia. Lipids in Health and Disease, v. 19, n. 1, 2020. DOI: https://doi.org/10.1186/s12944-020-01348-8 DOI: https://doi.org/10.1186/s12944-020-01402-8

SILVA, R. S. Complicações pós-operatórias em cirurgia bariátrica. Revista Brasileira de Cirurgia Digestiva, 2017.

SOUZA, A. C. Complicações da cirurgia bariátrica: revisão de literatura. Revista de Medicina, 2019. DOI: https://doi.org/10.22533/at.ed.8161923125

SUN, H. et al. Factors influencing gallstone formation. Biomolecules, v. 12, n. 4, 2022. DOI: https://doi.org/10.3390/biom12040550 DOI: https://doi.org/10.3390/biom12040550

TORRES, O. J. M. et al. Prevalência ultrassonográfica de litíase biliar. Revista do Colégio Brasileiro de Cirurgiões, v. 32, n. 1, 2005. DOI: https://doi.org/10.1590/S0100-69912005000100011

TSIRLINE, V. B. et al. Frequency and timing of cholecystectomy after bariatric surgery. Surgery for Obesity and Related Diseases, v. 10, n. 2, 2014. DOI: https://doi.org/10.1016/j.soard.2013.09.006 DOI: https://doi.org/10.1016/j.soard.2013.10.011

VURAL, A. et al. Increased gallstone formation after sleeve gastrectomy and the preventive role of ursodeoxycholic acid. Acta Gastro-Enterologica Belgica, v. 83, 2020.

YUAN, S. et al. Obesity, type 2 diabetes, lifestyle factors, and risk of gallstone disease. Clinical Gastroenterology and Hepatology, 2021. DOI: https://doi.org/10.1016/j.cgh.2021.06.038 DOI: https://doi.org/10.1016/j.cgh.2020.12.034

Publicado

2026-05-04

Cómo citar

COLELITIASIS EN PACIENTES DESPUÉS DE CIRUGÍA BARIÁTRICA: REVISIÓN DE LA LITERATURA. (2026). REMUNOM, 13(08), 1-28. https://doi.org/10.66104/k7tssa54