EFFECTS OF ISCHEMIC PRECONDITIONING ON RESISTANCE EXERCISE PERFORMANCE: A SYSTEMATIC REVIEW
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https://doi.org/10.66104/af0s1t29Palabras clave:
Ischemic preconditioning, resistance training, strength training, exercise performance, systematic reviewResumen
Objective: this systematic review aimed to synthesize the evidence on the effects of ischemic preconditioning (IPC) on resistance exercise performance, as well as to identify methodological patterns across studies and discuss its practical applicability. Methodology: the review was conducted in accordance with PRISMA recommendations and registered in PROSPERO (CRD42024529191). Searches were carried out in January 2026 in PubMed, Scopus, SPORTDiscus, and Web of Science. Randomized experimental studies involving healthy adults, trained or untrained, submitted to IPC and compared with control or sham conditions, with assessment of strength, muscular endurance, and muscle thickness, were included. Of the 1,340 records initially identified, 11 studies met the eligibility criteria and composed the final synthesis. Results: overall, the studies showed satisfactory methodological quality, although risk-of-bias assessment indicated a predominance of 'some concerns,' particularly regarding randomization and the selection of reported results. Findings showed that IPC was mainly associated with acute ergogenic effects, including increases in repetitions to failure, total training volume, and, in some cases, maximal strength. The few chronic studies also suggested benefits for strength gains, but without consistent evidence of increased muscle thickness. Conclusions: it is concluded that IPC has the potential to improve resistance exercise performance, although methodological heterogeneity and the possible influence of placebo-related factors require cautious interpretation.
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ALLOIS, R.; PERTUSIO, R.; PAGLIARO, P.; ROATTA, S. Ischemic preconditioning: exploring local ergogenic mechanisms in non-fatiguing voluntary contractions. Frontiers in Physiology, [S. l.], v. 16, art. 1542394, 2025. DOI: https://doi.org/10.3389/fphys.2025.1542394
CARU, M.; LEVESQUE, A.; LALONDE, F.; CURNIER, D. An overview of ischemic preconditioning in exercise performance: a systematic review. Journal of Sport and Health Science, [S. l.], v. 8, n. 4, p. 355-369, 2019. DOI: https://doi.org/10.1016/j.jshs.2019.01.008
CARVALHO, L.; BARROSO, R. Ischemic preconditioning improves strength endurance performance. Journal of Strength and Conditioning Research, [S. l.], v. 33, n. 12, p. 3332-3337, 2019. DOI: https://doi.org/10.1519/JSC.0000000000002846
CARVALHO, L.; CONCON, V.; MELONI, M.; DE SOUZA, E. O.; BARROSO, R. Effects of resistance training combined with ischemic preconditioning on muscle size and strength in resistance-trained individuals. Journal of Sports Medicine and Physical Fitness, [S. l.], v. 60, n. 11, p. 1431-1436, 2020. DOI: https://doi.org/10.23736/S0022-4707.20.11032-6
CRUZ, R.; TRAMONTIN, A. F.; OLIVEIRA, A. S.; CAPUTO, F.; DENADAI, B. S.; GRECO, C. C. Ischemic preconditioning increases spinal excitability and voluntary activation during maximal plantar flexion contractions in men. Scandinavian Journal of Medicine & Science in Sports, [S. l.], v. 34, n. 3, art. e14591, 2024. DOI: https://doi.org/10.1111/sms.14591
DE SOUZA, H. L. R.; ARRIEL, R. A.; HOHL, R.; DA MOTA, G. R.; MAROCOLO, M. Is ischemic preconditioning intervention occlusion-dependent to enhance resistance exercise performance? Journal of Strength and Conditioning Research, [S. l.], v. 35, n. 10, p. 2706-2712, 2021a. DOI: https://doi.org/10.1519/JSC.0000000000003224
DE SOUZA, H. L. R.; ARRIEL, R. A.; MOTA, G. R.; HOHL, R.; MAROCOLO, M. Does ischemic preconditioning really improve performance or it is just a placebo effect? PLOS ONE, [S. l.], v. 16, n. 5, art. e0250572, 2021b. DOI: https://doi.org/10.1371/journal.pone.0250572
KATAOKA, R.; SONG, J.; YAMADA, Y.; HAMMERT, W.; SEFFRIN, A.; SPITZ, R.; WONG, V.; KANG, A.; LOENNEKE, J. The impact of different ischemic preconditioning pressures on pain sensitivity and resistance exercise performance. Journal of Strength and Conditioning Research, [S. l.], v. 38, n. 5, p. 864-872, 2024. DOI: https://doi.org/10.1519/JSC.0000000000004718
MAROCOLO, M.; BILLAUT, F.; DA MOTA, G. R. Ischemic preconditioning and exercise performance: an ergogenic aid for whom? Frontiers in Physiology, [S. l.], v. 9, art. 1874, 2018. DOI: https://doi.org/10.3389/fphys.2018.01874
MAROCOLO, M.; DA MOTA, G. R.; SIMIM, M. A. M.; APPELL CORIOLANO, H. J. Myths and facts about the effects of ischemic preconditioning on performance. International Journal of Sports Medicine, [S. l.], v. 37, n. 2, p. 87-96, 2015. DOI: https://doi.org/10.1055/s-0035-1564253
MAROCOLO, M.; HOHL, R.; ARRIEL, R. A.; MOTA, G. R. Ischemic preconditioning and exercise performance: are the psychophysiological responses underestimated? European Journal of Applied Physiology, [S. l.], v. 123, n. 4, p. 683-693, 2023. DOI: https://doi.org/10.1007/s00421-022-05109-9
MAROCOLO, M.; MAROCOLO, I. C.; DA MOTA, G. R.; SIMÃO, R.; MAIOR, A. S.; CORIOLANO, H. J. A. Beneficial effects of ischemic preconditioning in resistance exercise fade over time. International Journal of Sports Medicine, [S. l.], v. 37, n. 10, p. 819-824, 2016a. DOI: https://doi.org/10.1055/s-0042-109066
MAROCOLO, M.; SIMIM, M. A. M.; BERNARDINO, A.; MONTEIRO, I. R.; PATTERSON, S. D.; DA MOTA, G. R. Ischemic preconditioning and exercise performance: shedding light through smallest worthwhile change. European Journal of Applied Physiology, [S. l.], v. 119, n. 10, p. 2123-2149, 2019. DOI: https://doi.org/10.1007/s00421-019-04214-6
MAROCOLO, M.; SOUZA, H. L. R.; SURKE, P.; FERRAUTI, A. Potential short- and long-term physiological effects of ischemic preconditioning as an ergogenic aid: revisiting foundational mechanisms and applications. Sports Medicine, [S. l.], v. 55, n. 7, p. 1547-1557, 2025. DOI: https://doi.org/10.1007/s40279-025-02232-3
MAROCOLO, M.; WILLARDSON, J. M.; MAROCOLO, I. C.; DA MOTA, G. R.; SIMÃO, R.; MAIOR, A. S. Ischemic preconditioning and placebo intervention improves resistance exercise performance. Journal of Strength and Conditioning Research, [S. l.], v. 30, n. 5, p. 1462-1469, 2016b. DOI: https://doi.org/10.1519/JSC.0000000000001232
MORLEY, W. N.; MURRANT, C. L.; BURR, J. F. Ergogenic effect of ischemic preconditioning is not directly conferred to isolated skeletal muscle via blood. European Journal of Applied Physiology, [S. l.], v. 123, n. 8, p. 1851-1861, 2023. DOI: https://doi.org/10.1007/s00421-023-05197-1
MOTA, G. R.; RIGHTMIRE, Z. B.; MARTIN, J. S.; MCDONALD, J. R.; KAVAZIS, A. N.; PASCOE, D. D.; GLADDEN, L. B. Ischemic preconditioning has no effect on maximal arm cycling exercise in women. European Journal of Applied Physiology, [S. l.], v. 120, n. 2, p. 369-380, 2020. DOI: https://doi.org/10.1007/s00421-019-04281-9
MURRY, C. E.; JENNINGS, R. B.; REIMER, K. A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, [S. l.], v. 74, n. 5, p. 1124-1136, 1986. DOI: https://doi.org/10.1161/01.CIR.74.5.1124
NOVAES, J. da S.; TELLES, L. G. da S.; MONTEIRO, E. R.; ARAUJO, G.; VINGREN, J. L.; PANZA, P. S.; REIS, V. M. H.; LATERZA, M. C.; VIANNA, J. M. Ischemic preconditioning improves resistance training session performance. Journal of Strength and Conditioning Research, [S. l.], v. 35, n. 11, p. 2993-2998, 2021. DOI: https://doi.org/10.1519/JSC.0000000000003532
O'BRIEN, L.; JACOBS, I. Methodological variations contributing to heterogenous ergogenic responses to ischemic preconditioning. Frontiers in Physiology, [S. l.], v. 12, art. 656980, 2021. DOI: https://doi.org/10.3389/fphys.2021.656980
O'BRIEN, L.; JACOBS, I. Potential physiological responses contributing to the ergogenic effects of acute ischemic preconditioning during exercise: a narrative review. Frontiers in Physiology, [S. l.], v. 13, art. 1051529, 2022. DOI: https://doi.org/10.3389/fphys.2022.1051529
OUZZANI, M.; HAMMADY, H.; FEDOROWICZ, Z.; ELMAGARMID, A. Rayyan: a web and mobile app for systematic reviews. Systematic Reviews, [S. l.], v. 5, n. 1, art. 210, 2016. DOI: https://doi.org/10.1186/s13643-016-0384-4
PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, [S. l.], v. 372, art. n71, 2021. DOI: https://doi.org/10.1136/bmj.n71
RODRIGUES, A. L.; IDE, B. N.; SASAKI, J. E.; DE OLIVEIRA, D. C. X.; ASSUMPÇÃO, C. D. O.; MAROCOLO, M.; MOTA, G. R. Ischemic preconditioning improves the bench-press maximal strength in resistance-trained men. International Journal of Exercise Science, [S. l.], v. 16, n. 4, p. 217-229, 2023. DOI: https://doi.org/10.70252/JLBH8684
SALVADOR, A. F.; AGUIAR, R. A. de; LISBÔA, F. D.; PEREIRA, K. L.; CRUZ, R. S. D. O.; CAPUTO, F. Ischemic preconditioning and exercise performance: a systematic review and meta-analysis. International Journal of Sports Physiology and Performance, [S. l.], v. 11, n. 1, p. 4-14, 2016. DOI: https://doi.org/10.1123/ijspp.2015-0204
SLYSZ, J. T.; BURR, J. F. Ischemic preconditioning: modulating pain sensitivity and exercise performance. Frontiers in Physiology, [S. l.], v. 12, art. 696488, 2021. DOI: https://doi.org/10.3389/fphys.2021.696488
SMART, N. A.; WALDRON, M.; ISMAIL, H.; GIALLAURIA, F.; VIGORITO, C.; CORNELISSEN, V.; DIEBERG, G. Validation of a new tool for the assessment of study quality and reporting in exercise training studies: TESTEX. International Journal of Evidence-Based Healthcare, [S. l.], v. 13, n. 1, p. 9-18, 2015. DOI: https://doi.org/10.1097/XEB.0000000000000020
SOUZA, H. L. R.; OLIVEIRA, G. T.; MEIRELES, A.; SANTOS, M. P. dos; VIEIRA, J. G.; ARRIEL, R. A.; PATTERSON, S. D.; MAROCOLO, M. Does ischemic preconditioning enhance sports performance more than placebo or no intervention? A systematic review with meta-analysis. Journal of Sport and Health Science, [S. l.], v. 14, art. 101010, 2025. DOI: https://doi.org/10.1016/j.jshs.2024.101010
STERNE, J. A. C. et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ, [S. l.], v. 366, art. l4898, 2019. DOI: https://doi.org/10.1136/bmj.l4898
SURKAR, S. M.; BLAND, M. D.; MATTLAGE, A. E.; CHEN, L.; GIDDAY, J. M.; LEE, J. M.; HERSHEY, T.; LANG, C. E. Effects of remote limb ischemic conditioning on muscle strength in healthy young adults: a randomized controlled trial. PLOS ONE, [S. l.], v. 15, n. 2, art. e0227263, 2020. DOI: https://doi.org/10.1371/journal.pone.0227263
TEIXEIRA, A. L.; GANGAT, A.; BOMMARITO, J. C.; BURR, J. F.; MILLAR, P. J. Ischemic preconditioning acutely improves functional sympatholysis during handgrip exercise in healthy males but not females. Medicine & Science in Sports & Exercise, [S. l.], v. 55, n. 7, p. 1250-1257, 2023. DOI: https://doi.org/10.1249/MSS.0000000000003148
TELLES, L. G.; BILLAUT, F.; DE SOUZA RIBEIRO, A.; JUNQUEIRA, C. G.; LEITÃO, L.; BARRETO, A. C.; PANZA, P.; VIANNA, J. M.; DA SILVA NOVAES, J. Ischemic preconditioning with high and low pressure enhances maximum strength and modulates heart rate variability. International Journal of Environmental Research and Public Health, [S. l.], v. 19, n. 13, art. 7655, 2022. DOI: https://doi.org/10.3390/ijerph19137655
TELLES, L. G. da S.; CARELLI, L. C.; BRÁZ, I. D.; JUNQUEIRA, C.; MONTEIRO, E. R.; REIS, V. M.; VIANNA, J. M.; NOVAES, J. da S. Effects of ischemic preconditioning as a warm-up on leg press and bench press performance. Journal of Human Kinetics, [S. l.], v. 75, n. 1, p. 267-277, 2020. DOI: https://doi.org/10.2478/hukin-2020-0055
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Derechos de autor 2026 Pedro Augusto Mariz Dantas, Camille dos Reis Molina, Jefferson da Silva Novaes; Adenilson Targino de Araújo Júnior; Pedro Henrique Marques de Lucena, Carlos Renato Paz, Natália Herculano Paz, Igor Mariz Dantas, Clizaldo Luiz Maroja Di Pace França, Camila Fernandes Pontes dos Santos, João Gabriel de Vasconcelos Chaves Pinheiro, Fábio Thiago Maciel da Silva, Daniel Almeida Marinho, Maria do Socorro Cirilo-Sousa
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