COMBINED SUPPLEMENTATION OF VITAMIN D, MAGNESIUM AND OMEGA-3 IN THE PROMOTION OF HEALTHY AGING: AN INTEGRATIVE REVIEW
DOI:
https://doi.org/10.66104/z12fkh46Keywords:
Healthy aging, Supplementation, Vitamin D, Magnesium, Omega-3.Abstract
Population aging represents one of the main contemporary public health challenges, requiring effective strategies to promote not only longevity but also quality of life and functional capacity over time. In this context, nutritional supplementation has been widely investigated as a potential approach to modulate physiological processes associated with aging. This study aims to critically analyze the scientific evidence regarding the combined supplementation of vitamin D, magnesium, and omega-3 fatty acids in promoting healthy and functional aging. This is an integrative literature review with a qualitative approach, conducted through systematic searches in PubMed, SciELO, and DYNAMED databases, using controlled descriptors and Boolean operators. A total of 12 studies published between 2020 and 2025 were selected according to predefined eligibility criteria. The findings indicate that vitamin D plays a key role in immune regulation, bone health, and neuromuscular function; magnesium acts as an essential enzymatic cofactor in bioenergetic processes and mitochondrial function; and omega-3 fatty acids exhibit anti-inflammatory, cardioprotective, and neuroprotective properties. The integrated analysis suggests a synergistic effect among these nutrients, contributing to the reduction of oxidative stress, modulation of chronic low-grade inflammation, and preservation of functional capacity. It is concluded that the combined supplementation of vitamin D, magnesium, and omega-3 shows promising potential in promoting healthy aging; however, further robust clinical trials are needed to consolidate the evidence and establish therapeutic protocols.
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Copyright (c) 2026 Donato Barbosa de Melo Neto, Maria Isabel Pereira Marques, Lindinêz Maria Torres Alencar, Paulo Sergio Rocha Lima, Vitoria Melo Rocha, Felipe Moraes Alecrim
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