EPIDEMIOLOGICAL PROFILE AND THERAPEUTIC MANAGEMENT OF MULTIPLE SCLEROSIS: A MULTICENTER STUDY
DOI:
https://doi.org/10.66104/2je4b293Keywords:
Multiple Sclerosis; Nursing; Chronic Disease.Abstract
The main objective of this study was to outline the therapeutic profile of Multiple Sclerosis (MS) in different regional centers of the states of Minas Gerais, Goiás, and São Paulo. This is a descriptive, exploratory, cross-sectional, and quantitative study. It was conducted in medication dispensing units of the Specialized Component of Pharmaceutical Assistance (CEAF) in medium and large-sized municipalities in the Southeast and Midwest regions, between November 2024 and November 2025. Eighty-three patients with a diagnosis confirmed by the McDonald Criteria and aged between 18 and 80 years participated in the study. Descriptive statistics and chi-square tests (significance of 5%) were used via SPSS 21.0 software. The study showed a predominance of females (68.7%) and self-declared white individuals (60.2%). A high level of education was observed, with 38 participants having higher education. The relapsing-remitting form was the most common, affecting 75% of participants in one of the analyzed centers. Natalizumab was the most frequently used medication globally (42.2%), followed by fingolimod (31.3%). There was a significant difference in treatments according to location (p < 0.001); natalizumab showed widespread use in specific centers. Low adherence to non-pharmacological therapies, such as physiotherapy and nutritional monitoring, was identified. It is concluded that the identified profile corroborates the literature regarding the prevalence in young, educated women. The variation in therapeutic choice between regions suggests the influence of local protocols and the logistical availability of infusion centers. The findings reinforce the need for a more robust multidisciplinary approach beyond drug treatment.
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BIONEWS. Income and education levels identified as risk factors for MS severity, study finds. Multiple Sclerosis News Today, 11 oct. 2023. Disponível em: https://multiplesclerosisnewstoday.com/news-posts/2023/10/11/income-education-levels-identified-risk-factors-ms-severity-study/. Acesso em: 25 set. 2025.
BRASIL. Ministério da Saúde. Portaria conjunta SAES/SECTICS nº 08, de 12 de setembro de 2024. Aprova o protocolo Clínico e Diretrizes Terapêuticas da Esclerose Múltipla (EM). Brasília-DF: Ministério da Saúde, 2024. Disponível em: https://www.gov.br/saude/pt-br/assuntos/pcdt/e/esclerose-multipla/view. Acesso em: 20 mar. 2026.
BROWNLEE, W. J.; Hardy, T.A.; FAZEKAS, F. et al. Diagnosis of multiple sclerosis: progress and challenges. The Lancet, v. 389, n. 10076, p. 1336-1346, 2017. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27889190/. Acesso em: 20 mar. 2026.
CARVALHEIRA, F. C. R. M. Saúde e bem-estar: uma abordagem sociológica da esclerose múltipla. 2025. Tese (Doutorado) — Universidade de Évoa – Instituto de Investigação e Formação Avançada, Portugal, 2025.
ELOSÚA, M. R.; VILLADANGOS, N. Executive functions in relapsing-remitting multiple sclerosis. Appl Neuropsychol adult, v. 32, n. 4, p. 944-952, 2025. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37930795/. Acesso em: 21 mai. 2026.
FIGUEIREDO, M. et al. Estratégias de coping na família da pessoa portadora de esclerose múltipla. Revista ROL de Enfermería, v. 43, n. 1, p. 124-128, 2020.
GHABAEE, D. N. Z.; BAGHERI-NESAMI, M. SHAFAROUDI, M. M. Relationship between spiritual well-being and quality of life in multiple sclerosis patients. Journal of Nursing and Midwifery Sciences, v. 3, n. 2, p. 25-31, 2016. Disponível em: https://brieflands.com/journals/jnms/articles/141233.pdf. Acesso em: 21 mai. 2026.
GUÍO-SÁNCHEZ, C.; CORRILLO-MARTÍNEZ, J. C.; DUARTE, L. et al. Demographic and clinical profile of late-onset multiple sclerosis: descriptive analysis in a Colombian reference centre. Multiple Sclerosis and Related Disorders, v. 101, p. 106592, 2025. Disponível em: https://pubmed.ncbi.nlm.nih.gov/40582075/. Acesso em: 10 abr. 2026.
GUO, J.; OLSSON, T.; HILLERT, J.; ALFREDSSON, L. et al. Education, lifestyle risk factors, and treatment choices and multiple sclerosis progression. JAMA Network Open, v. 8, n. 7, p. e2520142, 2025. Disponível em: https://pubmed.ncbi.nlm.nih.gov/40643911/. Acesso em: 10 abr. 2026.
HAMILTON, R.; CICCARELLI, O. Incidência de esclerose múltipla em pacientes negros: é hora de acabar com um mito médico racial. Neurology Journals, v. 98, n. 18, p.739-740, 2022.
KALB, R.; BROWN, T.R.; COOTE, S. et al. Exercise and lifestyle physical activity recommendations for people with multiple sclerosis throughout the disease course. Multiple Sclerosis Journal, v. 26, n. 12, p. 1459-1469, 2020. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC7575303/pdf/10.1177_1352458520915629.pdf. Acesso em: 21 mai. 2026.
KERBRAT, A.; HAMONIC, S.; LERAY, E. et al. Ten-year prognosis in multiple sclerosis: a better outcome in relapsing-remitting patients but not in primary progressive patients. European Journal of Neurology, v. 26, n. 12, p. 1459-1469, 2020. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.12600.
Acesso em: 10 mar. 2026.
LORENZONI, P. J.; WERNECK, L. C.; CRIPPA, A. C. S. et al. Is there a relationship between narcolepsy, multiple sclerosis and HLA-DQB1*06:02?. Arq Neuropsiquiatr, v. 75, n. 6, p. 345-348, 2017. Disponível em: https://www.scielo.br/j/anp/a/ftrycnxVY7tn34P7vpZgMNb/?format=pdf&lang=en. Acesso em: 30 abr. 2026.
LUBLIN, F. D.; HÄRING, D. A.; GANJGAHI, H. et al. How patients with multiple sclerosis acquire disability. Brain, v. 145, n. 9, p. 3147-3161, 2022. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35104840/. Acesso em: 10 abr. 2026.
MORTAZAVI, M. HIZARCI, Ö.; GERDES, L. A. et al. Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk: a scoping review of MRI studies. NeuroImage Clin, v. 31, p. 102734, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34171607/. Acesso em: 26 set. 2025.
NEVES, V. A.; PEREIRA, V. A. F. Verificar a eficácia da fisioterapia na esclerose múltipla, em pacientes sedentário – estudo de caso. Revista Eletrônica Múltiplo Saber, v. 2, n. 2, p. 1-29, 2024. Disponível em: https://www.inesul.edu.br/site/arquivos_fisioterapia/VERIFICAR_EFICACIA_FISIOTERAPIA_2024.pdf. Acesso em 21 mai. 2026.
NIINO, M.; MIYAZAKI, Y. Relapsing-remitting multiple sclerosis. Brain Nerve, v. 73, n. 5, p. 442-449, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34006674/. Acesso em 21 mai. 2026.
PERDICOÚLIS, M.A. Estado da arte no diagnóstico de Esclerose Múltipla. 2022. Dissertação (Mestrado) — Universidade da Beira Interior, Portugal, 2022.
POZZILLI, C.; PUGLIATTI, M.; VERMERSCH, P. et al. Diagnosis and treatment of progressive multiple sclerosis: a position paper. Eur J Neurol, v. 30, p. 9-21, 2023. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/ene.15593. Acesso em 24 mar. 2026.
RIBEIRO, K. M. C.; RIBEIRO, K. M. C.; SANTOS NETO, A. et al. Perfil epidemiológico das internações de pacientes com esclerose múltipla no Brasil. SEMPESq - Semana de Pesquisa da Unit-Alagoas, n. 8, 2020. Disponível em: https://eventos.set.edu.br/al_sempesq/article/view/13898. Acesso em: 26 set. 2025.
SAKODA, A.; MATSUSHITA, T.; NAKAMURA, Y. et al. Environmental risk factors for multiple sclerosis in Japanese people. Mult Scler Relat Disord, v. 38, p. 101872, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31812038/. Acesso em: 20 mai. 2026.
SANTOS, A. B. S.; COELHO, T. C. B.; ARAÚJO, E. M. Identificação racial e a produção da informação em saúde. Inferface (Botucatu), v. 17, n. 45, p. 341-55, 2013.
SHAYGANNEJAD, V.; MOHAMADIRIZI, S. Spiritual health in women with multiple sclerosis and its association with self-esteem. Journal of Education and Health Promotion, v. 9, n. 1, p. 64, 2020. Disponível em: https://journals.lww.com/jehp/fulltext/2020/09000/spiritual_health_in_women_with_multiple_sclerosis.64.aspx. Acesso em: 24 mai. 2026.
SIVACI, A. Ö.; SEFEROĞLU, M.; ÇINAR, B. P. et al. Clinical and demographic characteristics of late-onset multiple sclerosis: LOMS-TR study. Mult Scler Relat Disord, v. 84, p. 105469, 2024.
SORENSEN, P. S.; SELLEBJERG, F.; HATUNG, H. P. et al. The apparently milder course of multiple sclerosis: changes in the diagnostic criteria, therapy and natural history. Brain, v. 143, n. 9, p. 2637-2652, 2020. Disponível em: https://academic.oup.com/brain/article/143/9/2637/5876125. Acesso em 10 abr. 2025.
STOILOUDIS, P.; KESIDOU, E.; BAKIRTZIS, C. et al. The role of diet and interventions on multiple sclerosis: a review. Nutrients, v. 14, n. 6, p. 1150, 2022. Acesso em: https://pubmed.ncbi.nlm.nih.gov/35334810/. Acesso em 10 abr. 2025.
VIEIRA, B. R.; ZAPAROLI, A. S.; GABAN, R. et al. Esclerose múltipla: mecanismos patogênicos e avanços no diagnóstico e tratamento. In: FREITAS, G. B. L.; ALMEIDA, C. C. Imunologia e doenças infecciosas e parasitárias. 3ª Edição, Irati: Pasteur, 2025.
WALLIN, M. T.; CULPEPPER, W.J.; NICHOLS, E. et al. Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol, v. 18, n. 3, p. 269-285, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30679040/. Acesso em: 25 set. 2025.
WILLIAMS, M. ORLANDO, C; AKISANYA, J. et al. Multiple Sclerosis in black and Hispanic populations: serving the underserved. Neurologic Clinics, v. 42, n. 1, p. 295-317, 2024. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0733861923000579?via%3Dihub. Acesso em 24 mai. 2026.
ZHANG, Y.; REN, R.; YANG, L. et al. Sleep in multiple sclerosis: a systematic review and meta-analysis of polysomnographic findings. J Clin Sleep Med, v. 19, n. 2, p.252-265,2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36117421/. Acesso em: 20 mar. 2026.
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Copyright (c) 2026 Reila Campos Guimarães de Araújo, Djulie Hellen Tolentino de Lima , Fancielle Linder dos Santos, Deborah Perpétuo Guimarães de Araújo, Nathalia Oliveira Silva , Karynne Borges Cabral, Cácia Régia de Paula , Danilo Rocha Dias, Flávio Henrique Alves de Lima
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