DEVELOPMENT AND CHARACTERIZATION OF A BIOCOMPOSITE BASED ON CHITOSAN, CLAY, AND COLLAGEN
DOI:
https://doi.org/10.66104/z4pdj670Keywords:
Biopolymers, Topical Films, Montmorillonite, BiocompositesAbstract
The wound healing process requires appropriate conditions to promote tissue regeneration and minimize complications associated with injuries. In this context, topical films have been investigated as promising alternatives for use in dressings, acting as physical barriers capable of protecting the wound and maintaining an environment conducive to healing. Thus, the objective of this study was to develop and characterize biocomposite films based on chitosan, collagen, and montmorillonite for potential application in wound treatment. The films were produced by the solvent evaporation method and characterized through qualitative analysis, thickness, moisture content, solubility, swelling, and Fourier transform infrared spectroscopy (FTIR). The results showed the formation of homogeneous films with good structural integrity. Qualitative evaluation revealed a yellowish color attributed to chitosan, while the presence of collagen resulted in lighter and shinier surfaces; films containing montmorillonite exhibited greater opacity and lower flexibility due to the structural reinforcement effect exerted by the clay. Moisture analyses indicated higher water retention in formulations with higher chitosan content, while solubility tests showed greater dissolution in films containing collagen. The swelling test revealed good water absorption capacity. FTIR analyses confirmed the presence of characteristic bands of the polymer matrix constituents, in addition to evidencing intermolecular interactions between the components. Thus, the developed biocomposite films exhibited promising physicochemical properties for application in wound treatment, combining biocompatibility, low cost, and the use of natural materials.
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