DESENVOLVIMENTO E CARACTERIZAÇÃO DE BIOCOMPÓSITO BASEADO EM QUITOSANA/ ARGILA/ COLÁGENO
DOI:
https://doi.org/10.66104/z4pdj670Palavras-chave:
Biopolímeros, Filmes Tópicos, Montmorilonita, BiocompósitosResumo
O processo cicatricial requer condições adequadas para favorecer a regeneração tecidual e minimizar complicações associadas às lesões. Nesse contexto, filmes tópicos vêm sendo investigados como alternativas promissoras para aplicação em curativos, atuando como barreiras físicas capazes de proteger a ferida e manter um ambiente favorável à cicatrização. Assim, este trabalho teve como objetivo desenvolver e caracterizar filmes biocompósitos à base de quitosana, colágeno, e montmorilonita para potencial aplicação no tratamento de feridas. Os filmes foram produzidos pelo método de evaporação do solvente e caracterizados por meio de análises qualitativas, espessura, teor de umidade, solubilidade, intumescimento e espectroscopia no infravermelho com transformada de Fourier (FTIR). Os resultados evidenciaram a formação de filmes homogêneos, com boa integridade estrutural. A avaliação qualitativa demonstrou coloração amarelada atribuída à quitosana, enquanto a presença de colágeno promoveu superfícies mais claras e brilhantes, os filmes contendo montmorilonita apresentaram maior opacidade e menor maleabilidade, em razão do efeito de reforço estrutural exercido pela argila. As análises de umidade indicaram maior retenção hídrica em formulações com maior teor de quitosana, enquanto os ensaios de solubilidade demonstraram maior dissolução nos filmes contendo colágeno. O ensaio de intumescimento revelou boa capacidade de absorção de água. As análises de FTIR confirmaram a presença das bandas características dos constituintes da matriz polimérica, além de evidenciarem interações intermoleculares entre os componentes. Dessa forma, os filmes biocompósitos desenvolvidos apresentaram propriedades físico químicas promissoras para aplicação no tratamento de feridas, associando biocompatibilidade, baixo custo e utilização de materiais naturais.
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ABDULLAH, J. A. A.; JIMÉNEZ-ROSADO, M.; BENÍTEZ, J. J.; GUERRERO, A.; ROMERO, A. Biopolymer-Based Films Reinforced with FexOy-Nanoparticles. Polymers, [N.p.], vol. 14, no. 21, 1 Nov. 2022. Available at: https://doi.org/10.3390/polym14214487.
AKISANMI, P. Classification of Clay Minerals. Mineralogy. [S. l.]: IntechOpen, 2022. DOI 10.5772/intechopen.103841. Disponível em: https://www.intechopen.com/chapters/81885.
ALCÂNTARA, A. V. O.; ABREU, A. A. S.; GONÇALVES, C.; FUCIÑOS, P.; CERQUEIRA, M. A.; GAMA, F. M. P.; PASTRANA, L. M.; RODRIGUES, S.; AZEREDO, H. M. C. Bacterial cellulose/cashew gum films as probiotic carriers. LWT - Food Science and Technology, [s. l.], vol. 130, 1 ago. 2020. https://doi.org/10.1016/j.lwt.2020.109699.
AMARI, A.; ALZAHRANI, F. M.; KATUBI, K. M.; ALSAIARI, N. S.; TAHOON, M. A.; REBAH, F. Ben. Clay-polymer nanocomposites: Preparations and utilization for pollutants removal. Materials, [s. l.], vol. 14, no 6, 2 mar. 2021. https://doi.org/10.3390/ma14061365.
ANDONEGI, M.; HERAS, K. Las; SANTOS-VIZCAÍNO, E.; IGARTUA, M.; HERNANDEZ, R. M.; DE LA CABA, K.; GUERRERO, P. Structure-properties relationship of chitosan/collagen films with potential for biomedical applications. Carbohydrate Polymers, [N.p.], vol. 237, 1 Jun. 2020. Available at: https://doi.org/10.1016/j.carbpol.2020.116159.
ARANAZ, I.; ALCÁNTARA, A. R.; CIVERA, M. C.; ARIAS, C.; ELORZA, B.; HERAS CABALLERO, A.; ACOSTA, N. Chitosan: An Overview of Its Properties and Applications. Polymers, v. 13, n. 19, p. 3256, 24 set. 2021.
ASSIS, M.; NINA NINA, D. G.; SOUSA, K. dos S. J.; BONIFACIO, M.; DE SOUZA, A.; SIMÕES, M. C.; GRANITO, R.; DE OLIVEIRA, F.; RENNÓ, A. C. M. Green Marine Collagen–Chitosan Composites with Biocompatible, Hemostatic, and Pro-Healing Performance. ACS Applied Bio Materials, [N.p.], vol. 9, no. 6, pp. 3015–3028, 16 Mar. 2026. Available at: https://doi.org/10.1021/acsabm.5c02493.
ASHIQ, A.; SARKAR, B.; ADASSOORIYA, N.; WALPITA, J.; RAJAPAKSHA, A. U.; OK, Y. S.; VITHANAGE, M. Sorption process of municipal solid waste biochar-montmorillonite composite for ciprofloxacin removal in aqueous media. Chemosphere, [N.p.], vol. 236, p. 124384, Dec. 2019. Available at: https://doi.org/10.1016/j.chemosphere.2019.124384.
BALDUCCI, C.; ROSO, M.; ZAMUNER, A.; FALCIGNO, L.; D’AURIA, G.; BRUN, P.; DETTIN, M. Multilayer Electrospun Scaffolds of Opposite-Charged Chitosans. International Journal of Molecular Sciences, [N.p.], vol. 25, no. 6, p. 3256, 13 Mar. 2024. Available at: https://doi.org/10.3390/ijms25063256.
BARROS, ANA BEATRIZ DE SOUSA. Degradação térmica em filmes de polietileno reticulados. 2023. 67 f. Dissertação (Mestrado em Ciência e Engenharia de Materiais) - Universidade Federal da Paraíba, João Pessoa, 2021.
BECERRA, J.; RODRIGUEZ, M.; LEAL, D.; NORIS-SUAREZ, K.; GONZALEZ, G. Chitosan-collagen-hydroxyapatite membranes for tissue engineering. Journal of Materials Science: Materials in Medicine, [N.p.], vol. 33, no. 2, p. 18, 24 Feb. 2022. Available at: https://doi.org/10.1007/s10856-022-06643-w.
BEKAROǦLU, G. M.; İŞÇI, S. Raw and Purified Clay Minerals for Drug Delivery Applications. ACS Omega, [s. l.], vol. 7, no 43, p. 38825–38831, 1 nov. 2022. https://doi.org/10.1021/acsomega.2c04510.
BELGHAZDIS, M.; HACHEM, E.-K. Clay and Clay Minerals: A Detailed Review. International Journal of Recent Technology and Applied Science, [s. l.], vol. 4, no 2, p. 54–75, 29 set. 2022. https://doi.org/10.36079/lamintang.ijortas-0402.367.
BEN, Z. Y.; SAMSUDIN, H.; YHAYA, M. F. Glycerol: Its properties, polymer synthesis, and applications in starch based films. European Polymer Journal, [N.p.], vol. 175, p. 111377, jul. 2022. Disponível em: https://doi.org/10.1016/j.eurpolymj.2022.111377.
BERTOLINO, V.; CAVALLARO, G.; MILIOTO, S.; LAZZARA, G. Polysaccharides/Halloysite nanotubes for smart bionanocomposite materials. Carbohydrate Polymers, [s. l.], vol. 245, 1 out. 2020. https://doi.org/10.1016/j.carbpol.2020.116502.
BISHNOI, A.; CHANDLA, N. K.; TALWAR, G.; KHATKAR, S. K.; SHARMA, A. Mechanical Strength, Solubility, and Functional Studies of Developed Composite Biopolymeric Film. Journal of Food Processing and Preservation, [N.p.], vol. 2023, p. 1–19, 8 nov. 2023. Disponível em: https://doi.org/10.1155/2023/5108490.
CACCAMO, M. T.; MAVILIA, G.; MAVILIA, L.; LOMBARDO, D.; MAGAZÙ, S. Self-assembly processes in hydrated montmorillonite by FTIR investigations. Materials, [N.p.], vol. 13, no. 5, 1 Mar. 2020. Available at: https://doi.org/10.3390/ma13051100.
CARDOSO, H. P.; BACALHAU RODRIGUES, J. F.; NUNES DA SILVA, H.; GALDINO, T. P.; LUNA, C. B. B.; FOOK, M. V. L.; MONTAZERIAN, M.; BAINO, F.; DE LIMA SILVA, S. M. Chitosan/montmorillonite nanocomposite film as anticancer drug carrier: A promising biomaterial to treat skin cancers. Ceramics International, [N.p.], vol. 50, no. 11, pp. 18528–18539, Jun. 2024. Available at: https://doi.org/10.1016/j.ceramint.2024.02.337.
CAZÓN, P.; ANTONIEWSKA, A.; RUTKOWSKA, J.; VÁZQUEZ, M. Evaluation of easy-removing antioxidant films of chitosan with Melaleuca alternifolia essential oil. International Journal of Biological Macromolecules, [N.p.], vol. 186, pp. 365–376, Sep. 2021. Available at: https://doi.org/10.1016/j.ijbiomac.2021.07.035.
CIFTCI, H. An Introduction to Montmorillonite Purification. Montmorillonite Clay. [N.p.]: IntechOpen, 22 Dec. 2021. Available at: https://doi.org/10.5772/intechopen.98188.
CUPONE, I. E.; SANSONE, A.; MARRA, F.; GIORI, A. M.; JANNINI, E. A. Orodispersible Film (ODF) Platform Based on Maltodextrin for Therapeutical Applications. Pharmaceutics, [s. l.], vol. 14, no 10, p. 2011, 22 set. 2022. https://doi.org/10.3390/pharmaceutics14102011.
DAMATO, A.; VIANELLO, F.; NOVELLI, E.; BALZAN, S.; GIANESELLA, M.; GIARETTA, E.; GABAI, G. Comprehensive Review on the Interactions of Clay Minerals With Animal Physiology and Production. Frontiers in Veterinary Science, [s. l.], vol. 9, 10 maio 2022.
DEVERNOIS, E.; CORADIN, T. Synthesis, Characterization and Biological Properties of Type I Collagen–Chitosan Mixed Hydrogels: A Review. Multidisciplinary Digital Publishing Institute (MDPI), vol. 9, no. 7, 1 Jul. 2023. Available at: https://doi.org/10.3390/gels9070518.
DZIEDZIC, I.; KERTMEN, A. Methods of Chitosan Identification: History and Trends. AMG Transcend Association, vol. 12, no. 4, 30 Dec. 2023. Available at: https://doi.org/10.33263/LIANBS124.094.
EL-ARABY, A.; EL GHADRAOUI, L.; ERRACHIDI, F. Physicochemical Properties and Functional Characteristics of Ecologically Extracted Shrimp Chitosans with Different Organic Acids during Demineralization Step. Molecules, [N.p.], vol. 27, no. 23, 1 Dec. 2022. Available at: https://doi.org/10.3390/molecules27238285.
EL-SAWAH, A. A.; EL-NAGGAR, N. E.-A.; ELDEGLA, H. E.; SOLIMAN, H. M. Green synthesis of collagen nanoparticles by Streptomyces xinghaiensis NEAA-1, statistical optimization, characterization, and evaluation of their anticancer potential. Scientific Reports, [N.p.], vol. 14, no. 1, p. 3283, 8 Feb. 2024. Available at: https://doi.org/10.1038/s41598-024-53342-3.
FATHY, M. M.; MOHAMED, F. S.; ELBIALY, N. S.; ELSHEMEY, W. M. Multifunctional Chitosan-Capped Gold Nanoparticles for enhanced cancer chemo-radiotherapy: An invitro study. Physica Medica, [N.p.], vol. 48, pp. 76–83, 1 Apr. 2018. Available at: https://doi.org/10.1016/j.ejmp.2018.04.002.
FERNANDES, E. F. dos S.; AGUIAR, E. S.; LIMA, É. K. A. de; ALVES, K. E. D S.; FARIAS, J. R. de S.; ALMEIDA, Y. B. A. de; ALVES, M. E. R.; SILVA, H. de J. B. D; BRAGA, A. do N. S.; SANTOS, V. B. dos. Argila bentonita: uma breve revisão das propriedades e aplicações. Research, Society and Development, [s. l.], vol. 12, no 2, p. e7912239917, 21 jan. 2023. DOI 10.33448/rsd-v12i2.39917. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/39917.
FRANÇA, D. B.; ALCÂNTARA, A. C. S.; SILVA-FILHO, E. C.; FONSECA, M. G. Polymeric bionanocomposites based on montmorillonite - Materials in continuous interest. Quimica Nova, [s. l.], vol. 43, no 10, p. 1447–1462, 1 dez. 2020. https://doi.org/10.21577/0100-4042.20170602.
FU, H.; JIAN, X.; PAN, H. Bias in sediment chemical weathering intensity evaluation: A numerical simulation study. Earth-Science Reviews, [s. l.], vol. 246, 1 nov. 2023. https://doi.org/10.1016/j.earscirev.2023.104574.
HAHN, S.; HENNECKE, D. What can we learn from biodegradation of natural polymers for regulation? Environmental Sciences Europe, [s. l.], vol. 35, no 1, 1 dez. 2023. https://doi.org/10.1186/s12302-023-00755-y.
HAJJ, W. AL; SALLA, M.; KRAYEM, M.; KHALED, S.; HASSAN, H. F.; KHATIB, S. EL. Hydrolyzed collagen: Exploring its applications in the food and beverage industries and assessing its impact on human health – A comprehensive review. Heliyon, v. 10, n. 16, p. e36433, ago. 2024.
HÉRNANDEZ VÁZQUEZ, C. I.; DRACZYŃSKI, Z.; BORKOWSKI, D.; KAŹMIERCZAK, D. Enhancing Chitosan Fibers: A Dual Approach with Tripolyphosphate and Ursolic Acid. Polymers, [N.p.], vol. 16, no. 4, 1 Feb. 2024. Available at: https://doi.org/10.3390/polym16040461.
HOLEŠOVÁ, S.; ČECH BARABASZOVÁ, K.; HUNDÁKOVÁ, M.; KRATOŠOVÁ, G.; KALOČ, V.; JOSZKO, K.; GZIK-ZROSKA, B. Comprehensive study of antimicrobial polycaprolactone/clay nanocomposite films: Preparation, characterization, properties and degradation in simulated body fluid. Polymer Composites, [s. l.], vol. 45, no 10, p. 9280–9298, 10 jul. 2024. https://doi.org/10.1002/pc.28409.
JAFARI, H.; LISTA, A.; SIEKAPEN, M. M.; GHAFFARI-BOHLOULI, P.; NIE, L.; ALIMORADI, H.; SHAVANDI, A. Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering. Polymers, [N.p.], vol. 12, no 10, p. 2230, 28 set. 2020. Disponível em: https://doi.org/10.3390/polym12102230.
JIANG, L.; ZONG, J.; MA, C.; CHEN, S.; LI, H.; ZHANG, D. Characterization of sustained-release chitosan film loaded with rutin-β-cyclodextrin complex and glucoamylase. Journal of Food Science and Technology, [N.p.], vol. 57, no. 2, pp. 734–744, 17 Feb. 2020. Available at: https://doi.org/10.1007/s13197-019-04106-9.
JIMÉNEZ, F. V. B; PEÑA-CORONA, S. I.; FARAH, S. J.; JIMÉNEZ-VALDÉS, M. T.; PINEDA-PÉREZ, E.; ROMERO-MONTERO, A.; DEL PRADO-AUDELO, M. L.; BERNAL-CHÁVEZ, S. A.; MAGAÑA, J. J.; LEYVA-GÓMEZ, G. Films for Wound Healing Fabricated Using a Solvent Casting Technique. Pharmaceutics, [s. l.], vol. 15, no 7, 1 jul. 2023. https://doi.org/10.3390/pharmaceutics15071914.
JUNIOR, L. B.; BERTUCI, M. L.; FAKHOURI, F. M.; MARTELLI, S. M. Caracterização e biodegradação de filmes de quitosana e proteína isolada de soja incorporados com nanocristais de celulose / Characterization and biodegradation of chitosan and soy protein isolate films incorporated with cellulose nanocrystals. Brazilian Journal of Development, [N.p.], vol. 8, no 3, p. 16681–16718, 8 mar. 2022. Disponível em: https://doi.org/10.34117/bjdv8n3-078.
KATTI, K. S.; JASUJA, H.; JASWANDKAR, S. V.; MOHANTY, S.; KATTI, D. R. Nanoclays in medicine: a new frontier of an ancient medical practice. Materials Advances, [s. l.], vol. 3, no 20, p. 7484–7500, 31 ago. 2022. https://doi.org/10.1039/d2ma00528j.
KHUBIEV, O. M.; EGOROV, A. R.; KIRICHUK, A. A.; KHRUSTALEV, V. N.; TSKHOVREBOV, A. G.; KRITCHENKOV, A. S. Chitosan-Based Antibacterial Films for Biomedical and Food Applications. International Journal of Molecular Sciences, [s. l.], vol. 24, no 13, 1 jul. 2023. https://doi.org/10.3390/ijms241310738.
KRAJIŠNIK, D.; USKOKOVIĆ-MARKOVIĆ, S.; DAKOVIĆ, A. Chitosan–Clay Mineral Nanocomposites with Antibacterial Activity for Biomedical Application: Advantages and Future Perspectives. International Journal of Molecular Sciences, [s. l.], vol. 25, no 19, 1 out. 2024. https://doi.org/10.3390/ijms251910377.
KUMAR, A.; LINGFA, P. Sodium bentonite and kaolin clays: Comparative study on their FT-IR, XRF, and XRD. 2020. Materials Today: Proceedings. [N.p.]: Elsevier Ltd, 2020. vol. 22, pp. 737–742. Available at: https://doi.org/10.1016/j.matpr.2019.10.037.
KUMARI, N.; MOHAN, C. Basics of Clay Minerals and Their Characteristic Properties. Clay and Clay Minerals. [S. l.]: IntechOpen, 2021. https://doi.org/10.5772/intechopen.97672.
KULKARNI, P.; MANIYAR, M.; NALAWADE, M.; BHAGWAT, P.; PILLAI, S. Isolation, biochemical characterization, and development of a biodegradable antimicrobial film from Cirrhinus mrigala scale collagen. Environmental Science and Pollution Research, [N.p.], vol. 29, no. 13, pp. 18840–18850, 26 Mar. 2022. Available at: https://doi.org/10.1007/s11356-021-17108-y.
KUPERKAR, K.; ATANASE, L. I.; BAHADUR, A.; CRIVEI, I. C.; BAHADUR, P.
KUSMONO, K.; WILDAN, M. W.; LUBIS, F. I. Fabrication and Characterization of Chitosan/Cellulose Nanocrystal/Glycerol Bio-Composite Films. Polymers, [N.p.], vol. 13, no. 7, p. 1096, 30 Mar. 2021. Available at: https://doi.org/10.3390/polym13071096.
KUSMONO, K.; WILDAN, M. W.; LUBIS, F. I. Fabrication and Characterization of Chitosan/Cellulose Nanocrystal/Glycerol Bio-Composite Films. Polymers, [N.p.], vol. 13, no. 7, p. 1096, 30 Mar. 2021. Available at: https://doi.org/10.3390/polym13071096.
KUSNADI, K.; HERDIANA, Y.; ROCHIMA, E.; PUTRA, O. N.; MOHD GAZZALI, A.; MUCHTARIDI, M. Collagen-Based Nanoparticles as Drug Delivery System in Wound Healing Applications. International Journal of Nanomedicine, v. Volume 19, p. 11321–11341, nov. 2024.
LIU, Y.; ZHANG, C.; KONG, Y.; LIU, H.; GUO, J.; YANG, H.; DENG, L. Modification of Collagen Film via Surface Grafting of Taurine Molecular to Promote Corneal Nerve Repair and Epithelization Process. Journal of Functional Biomaterials, [N.p.], vol. 13, no. 3, p. 98, 17 Jul. 2022. Available at: https://doi.org/10.3390/jfb13030098.
LOPES, A. K. L. C.; CARVALHO, S. do N. de; SOUSA, J. di P. dos S.; MEIRELLES, L. M. A. Desenvolvimento e caracterização de máscaras peel-off à base de atapulgita. Research, Society and Development, [N.p.], vol. 9, no 8, p. e397985820, 9 jul. 2020. Disponível em: https://doi.org/10.33448/rsd-v9i8.5820.
MACEDO, J. B.; SANFELICE, R. C.; MERCANTE, L. A.; DOS SANTOS, D. M.; HABITZREUTER, F.; CAMPANA-FILHO, S. P.; PAVINATTO, A. Antimicrobial activity of chitosan and its derivatives: influence of its structural characteristics. Quimica Nova, [s. l.], vol. 45, no 6, p. 690–704, 2022. https://doi.org/10.21577/0100-4042.20170867.
MAKGOBOLE, M. U.; ONWUBU, S. C.; BARUWA, A.; MPOFANA, N.; OBIECHEFU, Z.; NAIDOO, D.; KHATHI, A.; MKHWANAZI, B. Optimization of Collagen Extraction from Fish Scales Using Tris-Glycine Buffer: A Taguchi Methodological Approach. Marine Drugs, [N.p.], vol. 22, no. 12, p. 562, 17 Dec. 2024. Available at: https://doi.org/10.3390/md22120562.
MARTÍNEZ RODRÍGUEZ, T.; VALENTINO, C.; RODRÍGUEZ POZO, F. R.; HERNÁNDEZ BENAVIDES, P.; ARREBOLA VARGAS, F.; PAREDES, J. M.; SAINZ-DÍAZ, C. I.; IGLESIAS, G. R.; ROSSI, S.; SANDRI, G.; MEDINA PÉREZ, M. del M.; AGUZZI, C. Formulative Study and Characterization of Novel Biomaterials Based on Chitosan/Hydrolyzed Collagen Films. Journal of Functional Biomaterials, [N.p.], vol. 15, no. 3, 1 Mar. 2024. Available at: https://doi.org/10.3390/jfb15030069.
MD FADILAH, N. I.; SHAHABUDIN, N. A.; MOHD RAZIF, R. A.; SANYAL, A.; GHOSH, A.; BAHARIN, K. I.; AHMAD, H.; MAAROF, M.; MOTTA, A.; FAUZI, M. B. Discovery of bioactive peptides as therapeutic agents for skin wound repair. Journal of Tissue Engineering, v. 15, 29 jan. 2024.
MEERA, K.; ARUN, K.; RAMESAN, M. T. Nanochitosan Reinforced Polyvinyl Alcohol/Cashew Gum Bio-blend Nanocomposites: Promising Materials for Future Frontiers. Journal of Polymers and the Environment, [N.p.], vol. 31, no. 10, pp. 4487–4505, 16 Oct. 2023. Available at: https://doi.org/10.1007/s10924-023-02909-8.
MELO, F. M.; PEIXOTO, D.; ALEIXO, C.; GONÇALVES, M. B. S.; RAZA, F.; PAWAR, K. D.; VEIGA, F.; LIU, M.; SANTOS, A. C. P. Nanoclays for wound management applications. Drug Delivery and Translational Research, [s. l.], vol. 13, no 4, p. 924–945, 2022. https://doi.org/10.1007/s13346-022-01279-3.
MESQUITA, A. B. D. S; DA SILVA, I. V.; DE FARIAS BRAZ, C. J.; DE CARVALHO, L. H.; BARBOSA, R.; PARANAGUA, J. H. L. F.; ALVES, T. S. Characterization of PHB/Clay Biocomposites Exposed to Degradation in an Aquatic Environment. Materials Research, [s. l.], vol. 26, 2023. https://doi.org/10.1590/1980-5373-MR-2023-0158.
METZE, F. K.; SANT, S.; MENG, Z.; KLOK, H.-A.; KAUR, K. Swelling-Activated, Soft Mechanochemistry in Polymer Materials. Langmuir, [N.p.], vol. 39, no. 10, pp. 3546–3557, 14 Mar. 2023. Available at: https://doi.org/10.1021/acs.langmuir.2c02801
MOKHTAR, A.; AHMED, A. B.; ASLI, B.; BOUKOUSSA, B.; HACHEMAOUI, M.; SASSI, M.; ABBOUD, M. Recent Advances in Antibacterial Metallic Species Supported on Montmorillonite Clay Mineral: A Review. Minerals, [s. l.], vol. 13, no 10, 1 out. 2023. https://doi.org/10.3390/min13101268.
MORA-LÓPEZ, D. S. DE LA; MADERA-SANTANA, T. J.; LÓPEZ-CERVANTES, J.; SÁNCHEZ-MACHADO, D. I.; AYALA-ZAVALA, J. F.; SOTO-VALDEZ, H. Development and characterization of chitosan-collagen films loaded with honey. Polímeros, v. 33, n. 3, 2023.
MURUGAN, G.; KHAN, A.; NILSUWAN, K.; KIM, J. T.; BENJAKUL, S.; RHIM, J. W. Multi-functional polysaccharides composite film containing cashew and jik leaf carbon dots: Properties and bioactivities. Applied Food Research, [s. l.], vol. 4, no 2, 1 dez. 2024. https://doi.org/10.1016/j.afres.2024.100590.
NILSUWAN, K.; THONGNOI, S.; PRODPRAN, T.; BENJAKUL, S. Properties and Characteristics of Film from Salmon Skin Acid-Soluble Collagen Solution as Influenced by Ultrasonication Process. Foods, [N.p.], vol. 14, no. 7, p. 1088, 21 Mar. 2025. Available at: https://doi.org/10.3390/foods14071088.
NISHIME, T. M. C.; WAGNER, R.; KOSTOV, K. G. Study of modified area of polymer samples exposed to a he atmospheric pressure plasma jet using different treatment conditions. Polymers, [N.p.], vol. 12, no. 5, 1 May 2020. Available at: https://doi.org/10.3390/POLYM12051028.
NOMICISIO, C.; RUGGERI, M.; BIANCHI, E.; VIGANI, B.; VALENTINO, C.; AGUZZI, C.; VISERAS, C.; ROSSI, S.; SANDRI, G. Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields. Pharmaceutics, [s. l.], vol. 15, no 5, 1 maio 2023. https://doi.org/10.3390/pharmaceutics15051368.
NOVAES, J.; DA SILVA FILHO, E. A.; BERNARDO, P. M. F.; YAPUCHURA, E. R. Preparation and characterization of Chitosan/Collagen blends containing silver nanoparticles. Polimeros, [N.p.], vol. 30, no. 2, 2020. Available at: https://doi.org/10.1590/0104-1428.00919.
OCAK, B. Film-forming ability of collagen hydrolysate extracted from leather solid wastes with chitosan. Environmental Science and Pollution Research, v. 25, n. 5, p. 4643–4655, 1 fev. 2018.
OLIVEIRA, M. A.; GONZAGA, M. L. C.; BASTOS, M. S. R.; MAGALHÃES, H. C. R.; BENEVIDES, S. D.; FURTADO, R. F.; ZAMBELLI, R. A.; GARRUTI, D. S. Packaging with cashew gum/gelatin/essential oil for bread: Release potential of the citral. Food Packaging and Shelf Life, [s. l.], vol. 23, 1 mar. 2019. https://doi.org/10.1016/j.fpsl.2019.100431.
OLIVEIRA, R. V.; KUMINECK JUNIOR, S. R.; GARCIA, M. C. F.; APATI, G. P.; LEITZKE, T. D. C. G.; SCHNEIDER, A. L. D. S.; PEZZIN, A. P. T. Biodegradable hydrophobic biocomposite based on green banana starch associated with bacterial cellulose. Revista Materia, [s. l.], vol. 27, no 1, 2022. https://doi.org/10.1590/1517-7076-RMAT-2021-49059.
PRASATHKUMAR, M.; SADHASIVAM, S. Chitosan/Hyaluronic acid/Alginate and an assorted polymers loaded with honey, plant, and marine compounds for progressive wound healing—Know-how. International Journal of Biological Macromolecules, [s. l.], vol. 186, p. 656–685, set. 2021. https://doi.org/10.1016/j.ijbiomac.2021.07.067.
QIAO, Z.; LIU, Z.; ZHANG, S.; YANG, Y.; WU, Y.; LIU, L.; LIU, Q. Purification of montmorillonite and the influence of the purification method on textural properties. Applied Clay Science, [N.p.], vol. 187, 15 Mar. 2020. Available at: https://doi.org/10.1016/j.clay.2020.105491.
QIN, C.; YUAN, X.; XIONG, T.; TAN, Y. Z.; WANG, H. Physicochemical properties, metal availability and bacterial community structure in heavy metal-polluted soil remediated by montmorillonite-based amendments. Chemosphere, [N.p.], vol. 261, 1 Dec. 2020. Available at: https://doi.org/10.1016/j.chemosphere.2020.128010.
RAFIEE, A.; MOZAFARI, N.; FEKRI, N.; MEMARPOUR, M.; AZADI, A. Preparation and characterization of a nanohydroxyapatite and sodium fluoride loaded chitosan-based in situ forming gel for enamel biomineralization. Heliyon, [N.p.], vol. 10, no. 2, 30 Jan. 2024. Available at: https://doi.org/10.1016/j.heliyon.2024.e24217.
RAJINIKANTH B, S.; RAJKUMAR, D. S. R.; K, K.; VIJAYARAGAVAN, V. Chitosan-Based Biomaterial in Wound Healing: A Review. Cureus, [s. l.], 29 fev. 2024. https://doi.org/10.7759/cureus.55193.
RANI RAJU, N.; SILINA, E.; STUPIN, V.; MANTUROVA, N.; CHIDAMBARAM, S. B.; ACHAR, R. R. Multifunctional and Smart Wound Dressings—A Review on Recent Research Advancements in Skin Regenerative Medicine. Pharmaceutics, [s. l.], vol. 14, no 8, 1 ago. 2022. https://doi.org/10.3390/pharmaceutics14081574.
RICCIO, B. V. F.; SILVESTRE, A. L. P.; MENEGUIN, A. B.; RIBEIRO, T. de C.; KLOSOWSKI, A. B.; FERRARI, P. C.; CHORILLI, M. Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review. AAPS PharmSciTech, [s. l.], vol. 23, no 7, p. 269, 28 set. 2022. https://doi.org/10.1208/s12249-022-02414-6.
SALAWI, A. An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review. Pharmaceuticals, [s. l.], vol. 15, no 7, p. 844, 9 jul. 2022. https://doi.org/10.3390/ph15070844.
SÁNCHEZ-CID, P.; JIMÉNEZ-ROSADO, M.; RUBIO-VALLE, J. F.; ROMERO, A.; OSTOS, F. J.; BENHNIA, R. E. I.; PEREZ-PUYANA, V. Biocompatible and Thermoresistant Hydrogels Based on Collagen and Chitosan. Polymers, [N.p.], vol. 14, no. 2, 1 Jan. 2022. Available at: https://doi.org/10.3390/polym14020272.
SANTANA, Julyana Galvão. Processamento e caracterização de filmes flexíveis e nanocompósitos de EVOH/GO tratados por radiação ionizante. 2019. 131 f. Dissertação (Mestrado em Ciências na Área de Tecnologia Nuclear – Materiais) - Autarquia Associada À Universidade De São Paulo, São Paulo, 2023. Disponível em: www.teses.usp.br.
SATCHANSKA, G.; DAVIDOVA, S.; PETROV, P. D. Natural and Synthetic Polymers for Biomedical and Environmental Applications. Polymers, [s. l.], vol. 16, no 8, 1 abr. 2024. https://doi.org/10.3390/polym16081159.
SEN, C. K.; FRIDAY, A.; KHANNA, S.; ROY, S. Collagen-Based Products in Wound, Skin, and Health CareAdvances in Wound CareMary Ann Liebert Inc. 2025.
SEVERO, A. M. C.; FOOK, M. V. L.; LEITE, I. F. PVA/chitosan hydrogels funcionalized with tea tree oil for application as dressings. Revista Materia, [s. l.], vol. 27, no 1, 2022. https://doi.org/10.1590/S1517-707620220001.1349.
SHEOKAND, B.; VATS, M.; KUMAR, A.; SRIVASTAVA, C. M.; BAHADUR, I.; PATHAK, S. R. Natural polymers used in the dressing materials for wound healing: Past, present and future. Journal of Polymer Science, [s. l.], vol. 61, no 14, p. 1389–1414, 15 jul. 2023. https://doi.org/10.1002/pol.20220734.
SILVA, C. N. S.; CRUZ, M. V.; FERNANDES, K. F.; BATISTA, K. A. Production of anti-inflammatory films based on cashew gum polysaccharide and polyvinyl alcohol for wound dressing applications. 3 Biotech, [s. l.], vol. 13, no 9, p. 299, 11 set. 2023. https://doi.org/10.1007/s13205-023-03686-w.
SILVA, M. C. C.; SANTOS, M. S. F.; BEZERRA, R. D. S.; ARAÚJO. J, E. A.; OSAJIMA, J. A.; SANTOS, M. R. M. C.; FONSECA, M. G.; SILVA, F. E. C. Kaolinite/cashew gum bionanocomposite for doxazosin incorporation and its release. International Journal of Biological Macromolecules, [s. l.], vol. 161, p. 927–935, 15 out. 2020. https://doi.org/10.1016/j.ijbiomac.2020.06.062.
SIONKOWSKA, A.; MICHALSKA-SIONKOWSKA, M.; WALCZAK, M. Preparation and characterization of collagen/hyaluronic acid/chitosan film crosslinked with dialdehyde starch. International Journal of Biological Macromolecules, [N.p.], vol. 149, pp. 290–295, Apr. 2020. Available at: https://doi.org/10.1016/j.ijbiomac.2020.01.262.
SONG, W.-K.; LIU, D.; SUN, L.-L.; LI, B.-F.; HOU, H. Physicochemical and Biocompatibility Properties of Type I Collagen from the Skin of Nile Tilapia (Oreochromis niloticus) for Biomedical Applications. Marine Drugs, [N.p.], vol. 17, no. 3, p. 137, 26 Feb. 2019. Available at: https://doi.org/10.3390/md17030137.
TARIQUE, J.; SAPUAN, S. M.; KHALINA, A. Effect of glycerol plasticizer loading on the physical, mechanical, thermal, and barrier properties of arrowroot (Maranta arundinacea) starch biopolymers. Scientific Reports, [N.p.], vol. 11, no. 1, 1 Dec. 2021. Available at: https://doi.org/10.1038/s41598-021-93094-y.
TIAN, G.; WANG, Z.; HUANG, Z.; XIE, Z.; XIA, L.; ZHANG, Y. Clays and Wound Healing. Materials, [s. l.], vol. 17, no 7, 1 abr. 2024. https://doi.org/10.3390/ma17071691.
TRIGUEIRO, P.; PEREIRA, J. P. de L.; FERREIRA, M. G.; SILVA, L. B.; NEVES, L.; PEÑA-GARCIA, R. R. Clay Minerals and Biopolymers in Film Design: Overview of Properties and Applications. Minerals, [s. l.], vol. 14, no 6, 1 jun. 2024. https://doi.org/10.3390/min14060613.
XIAO, F.; YAN, B. qi; ZOU, X. yun; CAO, X. qiang; DONG, L.; LYU, X. jun; LI, L.; QIU, J.; CHEN, P.; HU, S. gang; ZHANG, Q. jian. Study on ionic liquid modified montmorillonite and molecular dynamics simulation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, [N.p.], vol. 587, 20 Feb. 2020. Available at: https://doi.org/10.1016/j.colsurfa.2019.124311.
YAN, W.; CHEN, W.; MUHAMMAD, U.; ZHANG, J.; ZHUANG, H.; ZHOU, G. Preparation of α-tocopherol-chitosan nanoparticles/chitosan/montmorillonite film and the antioxidant efficiency on sliced dry-cured ham. Food Control, [s. l.], vol. 104, p. 132–138, 1 out. 2019. https://doi.org/10.1016/j.foodcont.2019.04.026.
YANG, Y.; WANG, X.; LI, Y.; YANG, F.; LIU, X.; WANG, A. Dencichine/palygorskite nanocomposite incorporated chitosan/polyvinylpyrrolidone film for accelerating wound hemostasis. International Journal of Biological Macromolecules, [s. l.], vol. 275, p. 133399, ago. 2024. https://doi.org/10.1016/j.ijbiomac.2024.133399.
YAZDI, J. S.; SALARI, M.; EHRAMPOUSH, M. H.; BAKOUEI, M. Development of active chitosan film containing bacterial cellulose nanofibers and silver nanoparticles for bread packaging. Food Science & Nutrition, [N.p.], vol. 12, no. 10, pp. 8186–8199, 23 Oct. 2024. Available at: https://doi.org/10.1002/fsn3.4424.
YONG, Q.; XU, D.; LIU, Q.; XIAO, Y.; WEI, D. Advances in polymer‐based matte coatings: A review. Polymers for Advanced Technologies, [N.p.], vol. 33, no 1, p. 5–19, 17 jan. 2022. Disponível em: https://doi.org/10.1002/pat.5508.
YU, R.; ZHANG, H.; GUO, B. Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering. Nano-Micro Letters, [s. l.], vol. 14, no 1, p. 1, 2 dez. 2022. https://doi.org/10.1007/s40820-021-00751-y.
ZHANG, Z.; ZHANG, L.; LI, C.; XIE, X.; LI, G.; HU, Z.; LI, S. Research progress of chitosan-based biomimetic materials. Marine Drugs, [s. l.], vol. 19, no 7, 1 jul. 2021. https://doi.org/10.3390/md19070372.
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